Puberty and Microvascular Function in Healthy Children and Adolescents

Radtke, Thomas; Khattab, Kerstin; Eser, Prisca; Kriemler, Susi; Saner, Hugo; Wilhelm, Matthias

doi:10.1016/j.jpeds.2012.04.033

Cited by 40 publications

(53 citation statements)

References 29 publications

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“…Therefore, the influence of age appears to be unique only to the digital reactive hyperemia technique and is likely related to the method itself, and not a physiological phenomenon related to pubertal development, as has been previously reported. 15,16,20 The finding is in line with our original hypothesis that mechanical/structural factors associated with the finger probes (i.e., the “one size fits all” finger probe developed for adults may not be valid for children) likely explains the low RHI values often observed among younger children.…”

Section: Discussionsupporting

confidence: 86%

“…20 Additionally, a significant positive association between SBP and RHI has been reported among adults. 25 Variables excluded due to multi-collinearity concerns may have contributed to this observation.…”

Section: Discussionmentioning

confidence: 98%

“…Subsequently, two separate research groups reported interesting associations between pubertal development and RHI 15,20 and between age, sex, and RHI 16 in children and adolescents. In an attempt to investigate these relationships further and compare them to another endothelial function technique, we conducted a study in which we simultaneously measured RHI along with FMD to evaluate their respective associations with age, sex, height, weight, blood pressure, body mass index (BMI), and finger volume.…”

Section: Introductionmentioning

confidence: 99%

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Younger age is associated with lower reactive hyperemic index but not lower flow-mediated dilation among children and adolescents

et al. 2014

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Background The use of digital reactive hyperemia as a measure of endothelial function among children and adolescents is becoming increasingly common. However, unexpected observations of low reactive hyperemic index values in younger children in our laboratory led us to conduct a study evaluating the influence of age, sex, height, weight, blood pressure, body mass index (BMI), and finger volume on RHI values. Methods Endothelial function, measured by digital reactive hyperemia (reactive hyperemic index: RHI) was assessed in 113 children and adolescents (mean age 12.4±3.8 years; 64 males), with 102 also assessed for brachial artery flow-mediated dilation (FMD) using ultrasound imaging. Associations with age, sex, height, weight, systolic and diastolic blood pressure (SBP, DBP), BMI, and finger volume were evaluated. Results Using GLM regression, age (β=0.03, P=0.014) and SBP (β=0.015, P=0.004) were significantly associated with RHI. No measures were associated with FMD. In the subset of individuals with measured finger volume, age (β=0.025, P=0.037) was the only measure significantly associated with log RHI. Similarly, no measures were associated with FMD. Conclusion Younger age is associated with lower RHI but not lower FMD among children and adolescents. These findings call into question the validity and usefulness of digital reactive hyperemia as a method to quantify endothelial function among younger children.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Younger age is associated with lower reactive hyperemic index but not lower flow-mediated dilation among children and adolescents

et al. 2014

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“…The Endo-PAT algorithm might not correctly account for physiological adaptations in childhood and puberty (62,63). Therefore, if RHI is used in children, the true peak dilation could be missed.…”

Section: Technological Advancements In Obesity-associated Endothelialmentioning

confidence: 99%

Childhood obesity–related endothelial dysfunction: an update on pathophysiological mechanisms and diagnostic advancements

et al. 2016

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“…Pubertal development and its associated hormonal changes complicate the study of endothelial function in children. RHI increases during puberty in both genders [138] and correlates to changes in estradiol and dehydroepiandrosterone sulfate in peripheral blood [139]. Both hormones upregulate eNOS concentration and activity [140].…”

Section: Peripheral Arterial Tonometrymentioning

confidence: 96%

National Trends in Beverage Consumption in Children from Birth to 5 Years: Analysis of NHANES Across Three Decades

2013

Childhood Obesity

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The association of obesity with noncommunicable diseases, such as cardiovascular complications and diabetes, is considered a major threat to the management of health care worldwide. Epidemiological findings show that childhood obesity is rapidly rising in Western society, as well as in developing countries. This pandemic is not without consequences and can affect the risk of future cardiovascular disease in these children. Childhood obesity is associated with endothelial dysfunction, the first yet still reversible step towards atherosclerosis. Advanced research techniques have added further insight on how childhood obesity and associated comorbidities lead to endothelial dysfunction. Techniques used to measure endothelial function were further brought to perfection, and novel biomarkers, including endothelial progenitor cells, were discovered. The aim of this paper is to provide a critical overview on both in vivo as well as in vitro markers for endothelial integrity. Additionally, an in-depth description of the mechanisms that disrupt the delicate balance between endothelial damage and repair will be given. Finally, the effects of lifestyle interventions and pharmacotherapy on endothelial dysfunction will be reviewed.

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Puberty and Microvascular Function in Healthy Children and Adolescents

Cited by 40 publications

References 29 publications

Younger age is associated with lower reactive hyperemic index but not lower flow-mediated dilation among children and adolescents

Younger age is associated with lower reactive hyperemic index but not lower flow-mediated dilation among children and adolescents

Childhood obesity–related endothelial dysfunction: an update on pathophysiological mechanisms and diagnostic advancements

National Trends in Beverage Consumption in Children from Birth to 5 Years: Analysis of NHANES Across Three Decades

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