Introduction: The prevalence of COVID-19 has negative psychological consequences on adolescents. The current study aims to compare self-compassion and corona anxiety in adolescents receiving and not receiving Covid-19 vaccine. Methods: Based on the purpose of the research, a causal-comparative method was used. The study population included all male high school students in Kermanshah in 2021-2022, of which 384 students were selected as research sample using multi-step cluster sampling. The self-compassion questionnaire (Neff, 2003) and the anxiety of Corona questionnaire (Alipour et al, 2019) were used to collect data. Results: The results of data analysis using independent t-test showed that there is a significant difference between the two groups in terms of self-compassion and corona anxiety (p <0.01). Moreover, the results of independent t-test showed that there is a significant difference between the two groups for components of self-friendliness, common humanity, mindfulness and psychological symptoms of corona anxiety and physical symptoms of corona anxiety (p <0.01). Generally, the results showed that vaccinated individuals had significantly more self-compassion, self-friendliness, shared humanity, and mindfulness, and less corona anxiety and physical and psychological symptoms (p <0.01).