Public Awareness and Knowledge of Herpes Zoster: Results of a Global Survey

Paek, Esther; Johnson, Robert W.

doi:10.1159/000240046

Cited by 26 publications

(33 citation statements)

References 33 publications

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“…The awareness of HZ among subjects varied markedly according to the country (17%-100%), and a global survey performed in 2006 indicated that 51% of Korean participants were aware of HZ. 23 In the present study, most subjects were aware of HZ and were relatively well informed about the disease, especially women, younger adults, subjects with higher educational level and higher monthly household income. Furthermore, our study highlights that, notwithstanding the efficacy and effectiveness of HZ vaccine confirmed in several large clinical studies, awareness of HZ vaccination is not sufficient.…”

Section: Discussionmentioning

confidence: 68%

“…20 Previous studies which were performed in other countries have indicated that the factors that influence awareness of HZ include the education level, race, history of HZ, or having witnessed someone with HZ. [21][22][23] In one US study, the individual decision to be vaccinated was associated with awareness of the disease, personal risk assessment, and the physician's recommendation. 24 The present study aimed to assess the current awareness of HZ and HZ vaccination as a function of age, gender, history of HZ, having witnessed someone with HZ, and socioeconomic status in Korea.…”

Section: Introductionmentioning

confidence: 99%

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Survey on public awareness, attitudes, and barriers for herpes zoster vaccination in South Korea

Yang

Cheong

Song

et al. 2015

Human Vaccines & Immunotherapeutics

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A cross-sectional study was performed to assess current public awareness of herpes zoster (HZ) and its vaccine, determine the factors that influence people's intention regarding HZ vaccination, and investigate the barriers for vaccination by changing decisions with sequential questions regarding knowledge, cost, and physician's recommendation in the Department of Infectious Diseases, Korea University Guro Hospital, in South Korea, between August 23 and September 15 of 2013. Among 603 subjects who completed the survey, 85.7% and 43.6% subjects were aware of HZ and HZ vaccination, respectively. Women, younger age group, those with higher income or higher education levels were more likely to be aware of HZ. Overall, 85.8% of subjects aware of HZ were willing to be vaccinated or vaccinate their parents. The main obstacles for the increased acceptance toward vaccination were the high cost and low perceived risk, which decreased acceptance to 60.2%. However, physician's recommendation reversed 69.5% of the refusal to accept HZ vaccine. These results indicate that expanding public education and physician's recommendations are important factors aimed at increasing HZ vaccine coverage rate.

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Section: Discussionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Survey on public awareness, attitudes, and barriers for herpes zoster vaccination in South Korea

Yang

Cheong

Song

et al. 2015

Human Vaccines & Immunotherapeutics

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“…In Arabic, Hezam innar means belt of fire; in Hindi, Baoisayaa daga means big rash; in Norwegian, Helvetesild means Hell's fire (also described as a bell of roses from Hell); and in Spanish, Culebrilla means small snake. 1 The most common complication of zoster is postherpetic neuralgia (PHN), operationally defined as pain lasting for more than 90 days after rash. Zoster may be followed by multiple neurologic disorders (meningoencephalitis, myelitis, and vasculopathy, including VZV temporal arteritis) as well as ocular disease (acute or progressive outer retinal necrosis).…”

Section: The Global Epidemiology Of Herpes Zostermentioning

confidence: 99%

The global epidemiology of herpes zoster

2013

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Varicella-zoster virus (VZV) is a ubiquitous, highly neurotropic, exclusively human a-herpesvirus. Primary infection usually results in varicella (chickenpox), after which VZV becomes latent in neurons of cranial nerve ganglia, dorsal root ganglia, and autonomic ganglia along the entire neuraxis. As humans undergo a natural decline in cell-mediated immunity (CMI) to VZV with age, VZV frequently reactivates to produce zoster, characterized by maculopapular or vesicular rash and dermatomal-distribution pain. Pain and rash usually occur within days of each other. Pain is severe and often burning. Colorful descriptions of zoster exist worldwide. In Arabic, Hezam innar means belt of fire; in Hindi, Baoisayaa daga means big rash; in Norwegian, Helvetesild means Hell's fire (also described as a bell of roses from Hell); and in Spanish, Culebrilla means small snake.1 The most common complication of zoster is postherpetic neuralgia (PHN), operationally defined as pain lasting for more than 90 days after rash. Zoster may be followed by multiple neurologic disorders (meningoencephalitis, myelitis, and vasculopathy, including VZV temporal arteritis) as well as ocular disease (acute or progressive outer retinal necrosis).Primary VZV infection produces VZV antibody and VZV-specific T-CMI. Serum of individuals 60-94 years old contains variable antibodies to VZV glycoproteins I-IV and to 3 nonglycosylated proteins; VZV antibodies in some elderly individuals with no history of varicella or zoster indicate subclinical infection. VZV antibodies do not protect against zoster or PHN. Recovery from varicella is associated with VZV-specific T-CMI, detected 1-2 weeks after disappearance of rash, consisting of CD4, CD8 effector, and memory T cells. T-cell immunity to VZV is more important than antibodies. Agammaglobulinemic patients do not produce VZV-specific antibodies but are protected against second episodes of varicella because they mount VZV-specific T-CMI responses. Individuals with T-CMI deficiency disorders or who are immunosuppressed have more zoster and more severe disease than normal hosts. In human stem cell recipients who received inactivated VZV vaccine, protection correlated with VZV-specific T-CMI but not with anti-VZV antibody.Nearly all children develop varicella and become latently infected. Attenuated VZV in varicella vaccine also becomes latent after childhood vaccination. Thus, zoster remains a global health issue, awaiting the development of a vaccine that produces permanent immunity and prevents virus reactivation. VZV-specific T-CMI maintains VZV in a latent state in ganglia. Immunity is boosted by subclinical reactivation of virus or environmental exposure. Zoster increases with age as VZV-specific T-CMI declines, evident even during the first 3 years after varicella, when VZV-specific memory CD4 T cells decrease. After mid-life, antigenic stimulation provided by re-exposure and asymptomatic reactivation are not sufficient to maintain VZV-specific Tcell immunity. Comparison of CMI response to VZV antigen in vi...

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“…This was similar to a survey conducted which showed higher knowledge in developed countries and poor knowledge in developing ones. 5 Twelve percent of the patients were initially handled by traditional healers, with a belief on them, who used to apply herbal medicines and draw animal figure in the periphery of lesions. Some of the visitors believed that the circumferential involvement of herpes zoster is fatal.…”

Section: Discussionmentioning

confidence: 99%

“…3,4 Although, HZ being a common cause of morbidity, there are very few studies on the epidemiology, clinical profiles and the studies regarding the knowledge and awareness among the patients with HZ in South Asia. 5 Here-in, we describe a hospital-based study of herpes zoster in a central hospital of Nepal…”

Section: Introductionmentioning

confidence: 99%

Clinical and Epidemiological Profile of Herpes Zoster; A Cross-Sectional Study from Tertiary Hospital

Paudel¹,

Pandey²,

Tripathee³

et al. 2018

Med Phoenix

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Background:Herpes zoster is dermatomal neuropathic disease caused by reactivation of varicella zoster virus, characterized by vesicobullous eruptions. Although, being a common cause of morbidity, there are few clinicepidemiological studies and the studies regarding the knowledge and practice among the patients are nominal.Methods: This was descriptive observational study which included 100 consecutive patients with herpes zoster who presented to Department of Dermatology and Venereology in a Teaching Hospital, Kathmandu during the period from July 2014 to June 2015.Results: The annual incidence was 0.55%. Seventy two percent were males and 28 percent were females with the M: F=2.5:1. The average age of patients and mean duration of disease was 40.4 years and 5.5 days respectively. Ninety five percent were managed at OPD and 5 % of them needed hospitalization. Most common dermatome involved was thoracic (50%) followed by cervical (20%). Twelve percent had one or more provocative features including diabetes, steroid use, chemotherapy, surgical trauma etc. Twenty patients had definite history chicken pox.Twenty-five percent had local complication at the time of presentation. Fifty two percent had themselves identified the lesion as herpes zoster. However, only 10 had some knowledge about it. Twelve percent had visited traditional healers prior to hospital arrival. Conclusions:The results show varied clinicoepidemiologic patterns of herpes zoster. Major patient have less knowledge about it. A larger study would be necessary for better clinical, epidemiological and social behavioral data. Because of ignorance and tradition, awareness program should be conducted to reduce potential complications.

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Public Awareness and Knowledge of Herpes Zoster: Results of a Global Survey

Cited by 26 publications

References 33 publications

Survey on public awareness, attitudes, and barriers for herpes zoster vaccination in South Korea

Survey on public awareness, attitudes, and barriers for herpes zoster vaccination in South Korea

The global epidemiology of herpes zoster

Clinical and Epidemiological Profile of Herpes Zoster; A Cross-Sectional Study from Tertiary Hospital

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