Public health and evidence-informed policy-making: The case of a commonly used herbicide

Vainio, Harri

doi:10.5271/sjweh.3851

Cited by 20 publications

(13 citation statements)

References 14 publications

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“…Digestive cancers account for the largest number of cancer-related deaths worldwide with increasing incidence and mortality ( Ferlay et al, 2015 ; Ahmad et al, 2017 ; Bray et al, 2018 ; Vainio, 2020 ). In China, digestive cancers are the highest occurring type of cancer, among which, liver, stomach, and esophageal cancer also account for a large majority of incidences.…”

Section: Introductionmentioning

confidence: 99%

OTUB1 Recruits Tumor Infiltrating Lymphocytes and Is a Prognostic Marker in Digestive Cancers

Zhang

Qiu

2020

Front. Mol. Biosci.

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Background: The deubiquitinating enzyme (DUB) OTUB1 can regulate the process of ubiquitination, but the influence of OTUB1 on immunity, apoptosis, autophagy, and the prognosis of digestive cancers requires further exploration. Methods: OTUB1 expression was analyzed with the Oncomine and TIMER database. Kaplan-Meier plotter was used to calculate the association between OTUB1 and clinical prognosis. The regulation of OTUB1 on cancer immunocyte infiltration was determined by the TIMER database. The interaction between OTUB1 and immune genes, gene expression profiling (GEP), key genes of apoptosis and autophagy were analyzed via GEPIA. Protein-protein interaction (PPI), gene expression profiling (GEP), and functional pathway enrichment were also performed with the STRING and Pathway Common databases, respectively. Results: High OTUB1 expression was found in CHOL, LIHC, READ, ESCA, and COAD, which was significantly associated with the poorer OS of LIHC (HR = 2.07, 95% CI = 1.30-3.30, P = 0.002), with modifications by sex, stage, grade, and mutant burden. OTUB1 can promote the recruitment of B cells, CD8 + T cells, macrophages in ESCA, B cells, and neutrophils in LIHC. We determined a significant interaction between OTUB1 and USP8, RNF128, LRIG1, UBB, UBC, STAM2, RNF41, EGFR, RPS27A, and HGS by PPI. This functional pathway indicates the regulatory role of OTUB1on immune, apoptosis, and autophagy through its interaction with TP53 and ATG. Conclusions: OTUB1 performed as a molecular indicator of poor prognosis in digestive cancers, regulated the infiltration of tumor immunocytes, and exerted a significant influence on apoptosis and autophagy. OTUB1 is a potential antitumor target for digestive tumors.

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Section: Introductionmentioning

confidence: 99%

OTUB1 Recruits Tumor Infiltrating Lymphocytes and Is a Prognostic Marker in Digestive Cancers

Zhang

Qiu

2020

Front. Mol. Biosci.

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“…Registrants present their information with limited input from groups concerned about public health, safety, and the environment. Due to the absence of input from non-registrants, registration decisions may be made without the best scientific evidence [23].…”

Section: Limitations Of Pesticide Registration Procedures and Legal Actionmentioning

confidence: 99%

Pesticide Usage Is Compromising People’s Health in the United States: Ideas for Reducing Damages

Centner

2021

Agriculture

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The development of synthetic pesticides has provided new tools for addressing troublesome pests. A review of parts of the registration process for pesticides in the United States identifies an outdated evaluation system that undervalues health damages. Registration fails to adequately consider co‑formulants and effects of exposure to multiple chemicals. Frustration with failures to protect people and property from damages accompanying pesticide usage has led injured plaintiffs to resort to tort lawsuits to secure relief. However, litigation involves compensating injured persons after they are injured rather than preventing injury. A more proactive approach would be to prevent situations that injure people. This paper offers four ideas to reduce health damages accompanying pesticide usage. Slight adjustments to pesticide registration requirements can offer greater protection for people’s health.

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“…In 2015, EFSA's in-depth assessment of BPA exposure and toxicity concluded that bisphenol A does not pose a risk to consumers (including newborns, infants, children and adolescents) at current exposure levels. Moreover, the ADI was changed to 0.4 µg/kg bw/day [5].…”

Section: Dose/effect and Legislationmentioning

confidence: 99%

“…It has been observed that BPA appears to have proinflammatory activity, increasing some inflammation mediators such as TNF-α, IL-8 and IL-13, and decreasing the number of macrophages [35]. EFSA claims to have new data on the effect of BPA on the immune system of animals, however there is insufficient evidence to draw conclusions about the effect on humans [36].…”

Section: Immune Systemmentioning

confidence: 99%

Bisphenol A in Odontology: Recent data

Vautherin¹,

Cardoso²

2019

Clin Res Trial

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Background and Objective: Bisphenol A (BPA) is an organic compound of the aromatic family used mainly as a monomer, for more than 50 years in the production of polycarbonate plastics and epoxy resins. Nowadays, bisphenol A is a worrying substance that deserves special attention. The goal of this work is to focus on bisphenol A and its biological effects on the human body.Methods: A bibliographic search was performed in databases such as PubMed, b-On and Elsevier. The keywords used were: "Bisphenol A", "BPA", "Endocrin Disruptor Chemicals". Results:There are several known effects on the human body resulting from the exposure to BPA such as in the reproductive system, dentition, brain, behavior, cardiovascular and in immune systems. In the oral cavity, dental composites release bis-GMA and BPA immediately after placement but released doses are usually too low to lead to biological effects. Conclusion:There are other materials such as silorans, Ormocer® and ionomer glass cements that can be good alternatives. Clinical studies are still neaded to prove that these materials are better than the composites, being these ones still the most used materials in conservative dental medicine.

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Public health and evidence-informed policy-making: The case of a commonly used herbicide

Cited by 20 publications

References 14 publications

OTUB1 Recruits Tumor Infiltrating Lymphocytes and Is a Prognostic Marker in Digestive Cancers

OTUB1 Recruits Tumor Infiltrating Lymphocytes and Is a Prognostic Marker in Digestive Cancers

Pesticide Usage Is Compromising People’s Health in the United States: Ideas for Reducing Damages

Bisphenol A in Odontology: Recent data

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