Public health implications of endocrine disrupting chemicals in drinking water and aquatic food resources in Nigeria: A state-of-the-science review

Ibor, Oju R.; Nnadozie, Prince; Ogarekpe, Dinah M.; Idogho, Omokhudu; Anyanti, Jennifer; Aziobu, Dennis; Onyezobi, Chinedu; Chukwuka, Azubuike V.; Adeougn, Aina O.; Arukwe, Augustine

doi:10.1016/j.scitotenv.2022.159835

Cited by 11 publications

(2 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Communities is such areas rely on water sources such as wells, rivers, and lagoons. In Lagos Nigeria, EDCs at concentrations around 2.5 µg/L were detected in lagoons [195]. As a result of the higher density of contaminant sources, exposure risks are also likely to be significant [24].…”

Section: High-risk Environmentsmentioning

confidence: 99%

Drinking Water Systems as a Cocktail of Emerging Organic Contaminants: Occurrence, Public Health Risks, and Research Needs

Marumure,

Simbanegavi,

Makuvara

et al. 2023

Preprint

View full text Add to dashboard Cite

Emerging organic contaminants (EOCs) of anthropogenic origins are ubiquitous in environmental compartments, including aquatic systems. Thus, EOCs have attracted considerable research and public attention due to their potential human and ecological health risks. However, compared to other aquatic environments such as wastewater systems, comprehensive reviews focussing on the occurrence and human health risks of EOCs in drinking water systems are still lacking. Therefore, to address this knowledge gap, the current review posits that drinking water systems harbour a cocktail of toxic EOCs, which pose public health risks via multiple exposure routes. In the present review, global evidence is examined to track EOCs along the source-pathway-receptor-impact-mitigation (SPRIM) continuum. Evidence shows that, various groups of EOCs, including pharmaceuticals and personal care products, solvents, plasticizers, endocrine disrupting compounds, gasoline additives, per- and polyfluoroalkyl substances (PFAS), food colourants, artificial sweeteners, and musks and fragrances, have been detected in drinking water systems. The anthropogenic sources of EOCs detected in drinking water systems, including wastewater systems and industrial emissions, are summarized. Further, the behaviour and fate of EOCs in the drinking water systems, including removal processes are discussed. Once in drinking water systems, human exposure to EOCs may occur via ingestion of contaminated drinking water and cooked foods, and possibly dermal contact and inhalation. The high-risk environments, and risk factors and behaviours predisposing humans to EOC exposure are discussed. Evidence on the human health risks of the various EOCs and a critique of the data are presented. Notably, besides inferential data, quantitative epidemiological evidence directly relating the occurrence of EOCs in drinking water systems to specific adverse human health outcomes is still scarce. Lastly, future research directions, including the need for quantitative public health risk assessment, and the application of emerging detection tools are discussed.

show abstract

Section: High-risk Environmentsmentioning

confidence: 99%

Drinking Water Systems as a Cocktail of Emerging Organic Contaminants: Occurrence, Public Health Risks, and Research Needs

Marumure,

Simbanegavi,

Makuvara

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…These crude toxicants such as PAHs, of which Benzo(a)pyrene (BaP) is one, are known reproductive health hazards and were found in both surface water and soil in these communities. [3][4][5] Benzo(a)pyrene diol epoxide (BPDE) is an epoxide derived from hydride of a Benzo(a)pyrene. It is used as a surrogate of PAHs, which can be measured to provide valuable information on toxicological exposure and disease risk.…”

Section: Introductionmentioning

confidence: 99%

Thyroid Hormone Levels in Mothers and Cord Blood at Delivery in Crude Oil Producing Community in Delta State, Nigeria

Emokpae,

Ogana

2024

Explor Res Hypothesis Med

View full text Add to dashboard Cite

Background and objectives: Harm caused by crude oil spillage and its associated environmental toxicants manifests slowly. This study examined the impact of crude oil environmental toxicants on neonates' thyroid and cognitive functions in crude oil-producing communities. Methods:The case-control study comprised 55 crude oil-exposed expectant mothers and 33 non-crude oil-exposed expectant mothers as controls. Serum Benzo Pyrene Dihydrodiol Epoxide (BPDE), triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH) were assayed in expectant mothers and neonates. Intelligence quotient and APGAR scores were determined in the children using Fagan's test of infant intelligence.Results: Serum TSH (p < 0.05) and BPDE (p < 0.001) were higher, while T3 and T3/T4 ratio were significantly lower (p < 0.001) in exposed pregnant women compared to the control. Cord blood TSH and T3/T4 ratio were lower (p < 0.001) while T4 and BDPE were higher (p < 0.001) in prenatally exposed neonates than prenatally non-exposed infants. Serum TSH correlated with BDPE (R 2 = 0.080, p < 0.036) and APGAR score (R 2 = 0.341, p < 0.012), while T3 and T4 were not associated with BDPE and APGAR score. TSH correlated with T3 (R 2 = 0.0.082, p < 0.05), T3 correlated with T4 (R2 = 0.111, p < 0.013) and TSH (R 2 = 0.082, p < 0.05). Exactly 54.5% (30/55) of prenatally exposed neonates had a low intelligence quotient compared to 36.4% (12/33) in prenatally non-exposed neonates. Conclusion:Crude oil and associated environmental pollutants might significantly affect the thyroid function. Environmental surveillance, biomonitoring and environmental cleanup are emphasized. Future research on the mechanisms of the observed toxicological effects on thyroid hormones and targeted protection of pregnant women and their offspring is suggested.

show abstract

Metal(loid)s, nitrate, polycyclic aromatic hydrocarbons, and radioactive contaminants in Nigerian water resources: state-of-the-art of their ecological and health risk assessments

Egbueri,

Agbasi,

Ezugwu

et al. 2024

Environ Dev Sustain

View full text Add to dashboard Cite

Public health implications of endocrine disrupting chemicals in drinking water and aquatic food resources in Nigeria: A state-of-the-science review

Cited by 11 publications

References 103 publications

Drinking Water Systems as a Cocktail of Emerging Organic Contaminants: Occurrence, Public Health Risks, and Research Needs

Drinking Water Systems as a Cocktail of Emerging Organic Contaminants: Occurrence, Public Health Risks, and Research Needs

Thyroid Hormone Levels in Mothers and Cord Blood at Delivery in Crude Oil Producing Community in Delta State, Nigeria

Metal(loid)s, nitrate, polycyclic aromatic hydrocarbons, and radioactive contaminants in Nigerian water resources: state-of-the-art of their ecological and health risk assessments

Contact Info

Product

Resources

About