Public Health Response to Pan-ResistantPseudomonas aeruginosaSequence Type 309 with Tandem Guiana Extended Spectrum β-Lactamases – Genetic Characterization andIn VivoEfficacy Assessment using Translational Murine Model

Abstract

Through phenotypic and genetic profiling, we identified the first pan resistantPseudomonas aeruginosahigh-risk sequence type 309 (ST-309) with Guiana Extended Spectrum β-Lactamase (GES) in California, prior to a national outbreak of VIM-GESPseudomonas aeruginosa(1). Our findings highlight detection and use of the translational murine model provide treatment implications for this emergingPseudomonas aeruginosa.