Public health response to two imported, epidemiologically related cases of Lassa fever in the Netherlands (ex Sierra Leone), November 2019

Overbosch, Femke W.; Boer, M.G.J. de; Veldkamp, Karin Ellen; Ellerbroek, Pauline M.; Bleeker‐Rovers, Chantal P.; Goorhuis, Abraham; Vugt, Michèle van; Eijk, Annemiek van der; Leenstra, Tjalling; Khargi, M; Ros, Jeanette; Brandwagt, Diederik; Haverkate, Manon; Swaan, Corien; Reusken, Chantal; Timen, Aura; Dissel, Jaap van

doi:10.2807/1560-7917.es.2020.25.15.2000265

Cited by 15 publications

(14 citation statements)

References 11 publications

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“…Although the distribution of each of the seven lineages appears to be restricted to specific geographic locations, the introduction of LASV from one country to another can occur (7,10) and may become more frequent with the rapid development of West Africa. In addition, LASV is the most frequently exported hemorrhagic fever virus, in most cases by health care workers returning to their home countries after contracting the disease (11,12). Although the WHO TPP indicates that vaccination should protect against lineages I to IV, conferring protection against all lineages would be preferred.…”

Section: Introductionmentioning

confidence: 99%

A single-shot Lassa vaccine induces long-term immunity and protects cynomolgus monkeys against heterologous strains

et al. 2021

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A safe and protective Lassa virus vaccine is crucially needed in Western Africa to stem the recurrent outbreaks of Lassa virus infections in Nigeria and the emergence of Lassa virus in previously unaffected countries, such as Benin and Togo. Major challenges in developing a Lassa virus vaccine include the high diversity of circulating strains and their reemergence from 1 year to another. To address each of these challenges, we immunized cynomolgus monkeys with a measles virus vector expressing the Lassa virus glycoprotein and nucleoprotein of the prototypic Lassa virus strain Josiah (MeV-NP). To evaluate vaccine efficacy against heterologous strains of Lassa virus, we challenged the monkeys a month later with heterologous strains from lineage II or lineage VII, finding that the vaccine was protective against these strains. A second cohort of monkeys was challenged 1 year later with the homologous Josiah strain, finding that a single dose of MeV-NP was sufficient to protect all vaccinated monkeys. These studies demonstrate that MeV-NP can generate both long-lasting immune responses and responses that are able to protect against diverse strains of Lassa virus.

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Section: Introductionmentioning

confidence: 99%

A single-shot Lassa vaccine induces long-term immunity and protects cynomolgus monkeys against heterologous strains

et al. 2021

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“…From the first case in 1969 until 2020, at least 35 exported cases of LF have been reported. These cases were exported from seven West African countries to nine countries in Europe, Asia, South Africa and North America [ 21 , 26 ] and several individuals have been repatriated due to the risk of LF transmission during outbreaks in endemic areas, or exposure during medical procedures [ 27 , 28 ].…”

Section: Geographical Distribution Of Lassa Fevermentioning

confidence: 99%

The niche of One Health approaches in Lassa fever surveillance and control

Arruda

Haider

Olayemi

et al. 2021

Ann Clin Microbiol Antimicrob

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Lassa fever (LF), a zoonotic illness, represents a public health burden in West African countries where the Lassa virus (LASV) circulates among rodents. Human exposure hinges significantly on LASV ecology, which is in turn shaped by various parameters such as weather seasonality and even virus and rodent-host genetics. Furthermore, human behaviour, despite playing a key role in the zoonotic nature of the disease, critically affects either the spread or control of human-to-human transmission. Previous estimations on LF burden date from the 80s and it is unclear how the population expansion and the improvement on diagnostics and surveillance methods have affected such predictions. Although recent data have contributed to the awareness of epidemics, the real impact of LF in West African communities will only be possible with the intensification of interdisciplinary efforts in research and public health approaches. This review discusses the causes and consequences of LF from a One Health perspective, and how the application of this concept can improve the surveillance and control of this disease in West Africa.

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“…Now, nosocomial infections are uncommon, and human transmission occurs mainly in village homes through direct contact with rodents or indirectly by consumption of contaminated food products, exposure to surfaces contaminated with rodent excreta, or inhalation of aerosolized virus [ 260 ]. Additionally, several cases have been recognized to be imported from individuals traveling from West Africa [ 261 , 262 ]. In West African villages where LASV is endemic, homes are usually devoid of food storage spaces such as cabinets (cupboards), so food is stored in plastic buckets or large flour bags on the ground or hung from ceilings or walls [ 263 ].…”

Section: How Do Viruses Spillover From Bats or Rodents To Humans?mentioning

confidence: 99%

Common Themes in Zoonotic Spillover and Disease Emergence: Lessons Learned from Bat- and Rodent-Borne RNA Viruses

Williams

Spruill-Harrell

Taylor

et al. 2021

Viruses

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Rodents (order Rodentia), followed by bats (order Chiroptera), comprise the largest percentage of living mammals on earth. Thus, it is not surprising that these two orders account for many of the reservoirs of the zoonotic RNA viruses discovered to date. The spillover of these viruses from wildlife to human do not typically result in pandemics but rather geographically confined outbreaks of human infection and disease. While limited geographically, these viruses cause thousands of cases of human disease each year. In this review, we focus on three questions regarding zoonotic viruses that originate in bats and rodents. First, what biological strategies have evolved that allow RNA viruses to reside in bats and rodents? Second, what are the environmental and ecological causes that drive viral spillover? Third, how does virus spillover occur from bats and rodents to humans?

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Public health response to two imported, epidemiologically related cases of Lassa fever in the Netherlands (ex Sierra Leone), November 2019

Cited by 15 publications

References 11 publications

A single-shot Lassa vaccine induces long-term immunity and protects cynomolgus monkeys against heterologous strains

A single-shot Lassa vaccine induces long-term immunity and protects cynomolgus monkeys against heterologous strains

The niche of One Health approaches in Lassa fever surveillance and control

Common Themes in Zoonotic Spillover and Disease Emergence: Lessons Learned from Bat- and Rodent-Borne RNA Viruses

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