Background: The emergence of Corona virus disease (COVID-19) and wide-spread counter-measures, such as quarantine and social distancing, can have a significant impact on mental health of individuals. Methods: This online study anonymously screened 13,332 individuals worldwide for acute psychological symptoms related to Corona virus disease 2019 (COVID-19) pandemic from March 29th to April 14th, 2020. A total of n=12,817 responses were considered valid. n=1077 participants from Europe were screened a second time during May 15th to May 30th to longitudinally ascertain the persistence of psychological effects. Results: Female gender, pre-existing psychiatric condition, and prior exposure to trauma were identified as notable factors associated with increased acute psychological symptoms during COVID-19. The same factors, in addition to, being related to someone who demised due to COVID-19 and using social media more than usual predicted persistence of psychological disturbances. Optimism, ability to share concerns with family and friends like usual, positive prediction about COVID-19, and daily exercise predicted fewer acute and persistent psychological symptoms. Conclusions: Females, psychiatric patients, and individuals with previous exposure to trauma are at increased risk of being persistently psychologically affected by COVID-19.