This study delves into the multifaceted macro-environmental factors shaping the tourism sector, encompassing economic, political, socio-cultural, technological, and sustainability dimensions. To navigate the challenges and opportunities within this dynamic industry, a deep understanding of these elements is crucial. The research aims to uncover the significant relationship between these factors and tourism domains through a systematic literature review and bibliometric analysis. Bridging theory and practice, it provides real-world implications for industry professionals, policymakers, researchers, and practitioners. This study contributes substantially to scholarly discourse, comprehensively exploring how diverse macro-environmental factors converge to shape the trajectory of the tourism and hospitality industries. Beyond academia, the findings offer practical insights for strategic decision-making, policy formulation, and future research initiatives in this ever-evolving field.