Ethics statement This narrative article contains no original data and thus issues of ethics, informed consent, and patient confidentiality do not apply.Conflicts of interest NCH reports personal fees, consultancy, lecture fees, and honoraria from Alliance for Better Bone Health, AMGEN, MSD, Eli Lilly, Servier, Shire, UCB, Consilient Healthcare, Kyowa Kirin, and Internis Pharma, outside the submitted work. JC has received lecture fees from Amgen and UCB and consultancy fees from Amgen. EVM reports personal fees, consultancy, lecture fees, and/or honoraria from Amgen, Consilient Healthcare, Fresenius Kabi, GSK,