The environmental quality of the modern city is a central issue in the Italian and international design debate. The pandemic and the perspective of a post-pandemic phase have accelerated the inevitable transformation of the living spaces—indoor and outdoor, urban and domestic—bringing out renewed awareness and new quality requirements. The need to achieve results to limit energy consumption, reduce polluting emissions, promote less land consumption, and conditions of urban resilience is becoming gradually urgent, according to European and national strategic, political and regulatory indications. Space quality requirements, which correspond to different conditions of quality of living, are generally identified in the physical and social accessibility of places and dwellings, in the production and availability of energy from renewable sources, in the availability of green public spaces, and in the opportunity to carry out leisure and sports activities. The paper investigates the transformation of public residential neighbourhoods, highlighting urban and technological design opportunities within the paradigm of eco-district and biophilic urbanism. Two case studies within the INA CASA Plan in Reggio Calabria—Sbarre Inferiori and San Brunello—will be the object of analysis and meta-design transformation scenarios to test with green quality requirements. The scenarios aim to explore microclimatic improvements for the districts, the redefinition of outdoor spaces, the implementations of technologies for clean energy production, and the containment of resources consumption. The object of the contribution goes towards principles of health and well-being of the communities, recognising the urban risk factors implicated in the global pandemic and the need to restore the existing building stock and residential estates. Eventually, the paper suggests a framework of actions, green technologies, and design options to manage those environmental concerns.