Publications of bone marrow transplants in Latin America. A report of the Latin American Group of Bone Marrow Transplantation

Ruíz‐Argüelles, Guillermo J.; Abello-Polo, V; Arrais‐Rodrigues, Celso; Bouzas, L.F.; Souza, Cármino Antônio de; Dufort, Gustavo; Gabús, Raúl; Galindo-Becerra, Laura Samantha; Gómez‐Almaguer, David; Hammerschlak, N; Jaime-Fagundo, Juan Carlos; Jaimovich, Gregorio; Karduss-Urueta, Amado J; Labastida-Mercado, Nancy; Nese, Martha; Pasqüini, Ricardo; Seber, Adriana

doi:10.1038/bmt.2015.107

Cited by 10 publications

(6 citation statements)

References 3 publications

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“…In many of these countries, the demand far exceeds the supply, and timely access to HSCT is problematic. In a report from Latin America, 93 an estimate of less than 10% of required transplants are carried out. Challenges include cost, donor availability, number of transplant centers, and lack of expertise.…”

Section: Social Determinants Of Prevention and Diagnosis Of Primary I...mentioning

confidence: 99%

Social determinants of health and primary immunodeficiency

Dinur-Schejter

Stepensky

2022

Annals of Allergy, Asthma & Immunology

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Section: Social Determinants Of Prevention and Diagnosis Of Primary I...mentioning

confidence: 99%

Social determinants of health and primary immunodeficiency

Dinur-Schejter

Stepensky

2022

Annals of Allergy, Asthma & Immunology

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“…A recent study determined that populations in almost half of the Eastern Mediterranean region countries do not have access to HSCT programs 12 . In another report from Latin America, an estimate of less than 10% of required transplants was carried out 13 . Additionally, transplant rates in Southeast Asia/Western Pacific region were 10‐fold lower compared with North America 14 .…”

Section: Introductionmentioning

confidence: 99%

“…12 In another report from Latin America, an estimate of less than 10% of required transplants was carried out. 13 Additionally, transplant rates in Southeast Asia/Western Pacific region were 10-fold lower compared with North America. 14 Hence, knowing these variables should help the decision regarding which patients should be prioritized for HSCT.…”

mentioning

confidence: 99%

Predictors of early death risk among untransplanted patients with combined immunodeficiencies affecting cellular and humoral immunity: A multicenter report

Al‐Herz

Ziyab

Adeli

et al. 2022

Pediatric Allergy Immunology

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Background: There is an increased demand for hematopoietic stem cell transplant (HSCT) to treat various diseases including combined immunodeficiencies (CID), with limited worldwide availability. Variables affecting the decision regarding CID patients' prioritization for HSCT are not known. We aimed to determine general, clinical, and immunologic factors associated with the higher risk of early death (≤6 months after diagnosis) in untransplanted CID patients.Methods: Data collection was done retrospectively from five centers and included general patients' information, and clinical and laboratory variables. Inclusion criteria were untransplanted patients who are either dead or alive with a follow-up period ≥6 months after diagnosis.Combined immunodeficiencies affecting cellular and humoral immunity (CID) are monogenic heterogeneous group of diseases. Affected patients are at risk of developing a wide range of manifestations mainly infections, immunodysregulation, and lymphoproliferation. 1,2 Based on newborn screening (NBS) results in 11 of the United States of America (USA), typical and atypical SCID were found to affect one in 58,000 newborns, 3 but it is higher in certain populations due to the high rate of consanguineous marriages or founder effect. [4][5][6] Combined immunodeficiencies can only be cured by hematopoietic stem cell transplant (HSCT) or gene therapies, and several variables were found to influence the outcome. [7][8][9][10][11] However, the decision on when to perform the HSCT and which patients should be prioritized is difficult on many occasions.The objective of this retrospective, multicenter study was to determine general, clinical, and immunologic factors associated with a higher risk of early death (within 6 months after diagnosis) in untransplanted CID patients. To our knowledge, there are no published data about this topic.The rationale for conducting this study is that HSCT is not accessible for most patients worldwide. A recent study determined that populations in almost half of the Eastern Mediterranean region countries do not have access to HSCT programs. 12 In another report from Latin America, an estimate of less than 10% of required transplants was carried out. 13 Additionally, transplant rates in Southeast Asia/Western Pacific region were 10-fold lower compared with North America. 14 Hence, knowing these variables should help the decision regarding which patients should be prioritized for HSCT. | MATERIAL S AND ME THODS | Patients' dataA detailed data form in an Excel sheet was prepared by the first author (WA) and was sent to participating centers. General patients' information including sex, parenteral consanguinity, family history of CID, and their outcomes were recorded. Clinical data included age of onset and diagnosis, and whether the patient was diagnosed by newborn screening or not. We also collected data about the following infections: adenovirus, aspergillus, Candida, cytomegalovirus, Epstein-Barr virus, Enterovirus, herpes simplex virus, influenza virus, respiratory syn...

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“…In several Latin-American and other middle-income countries, the decreases in costs have resulted in a larger number of patients being auto- and allografted, a larger number of papers published on the topic [11], and a better delivery of health care to patients with hematologic and nonhematologic diseases. It is rather obvious that more work needs to be done to make the SCT procedures available to more patients since these are irreplaceable in current medical practice.…”

Section: Tablementioning

confidence: 99%

Stem Cell Transplantation Procedures Are Becoming Affordable for Individuals Living in Developing (Middle-Income) Countries

Ruíz‐Argüelles

2015

Acta Haematol

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Publications of bone marrow transplants in Latin America. A report of the Latin American Group of Bone Marrow Transplantation

Cited by 10 publications

References 3 publications

Social determinants of health and primary immunodeficiency

Social determinants of health and primary immunodeficiency

Predictors of early death risk among untransplanted patients with combined immunodeficiencies affecting cellular and humoral immunity: A multicenter report

Stem Cell Transplantation Procedures Are Becoming Affordable for Individuals Living in Developing (Middle-Income) Countries

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