Publisher Correction: Functional expression of the transient receptor potential ankyrin type 1 channel in pancreatic adenocarcinoma cells

Cojocaru, Florentina; Şelescu, Tudor; Domocoş, Dan; Măruţescu, Luminiţa; Chirițoiu, Gabriela; Chelaru, Nicoleta-Raluca; Dima, Simona; Mihăilescu, Dan; Babeș, Alexandru; Cucu, Dana

doi:10.1038/s41598-021-88169-9

Cited by 2 publications

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“…From this study, TRPA1 emerged as a tumor-suppressor protein and its activation may be helpful for better therapy. In agreement with these results, TRPA1 decreased cell proliferation and migration in pancreatic adenocarcinoma cells [65]. Opposite results were obtained from breast cancer cells, where inhibition of TRPA1 reduced tumor growth [107].…”

Section: Redox Trp Channels and Inflammationsupporting

confidence: 79%

“…These results prove that apoptosis induced by TRPA1 is related to Ca 2+ signaling and to channel conducting properties of TRPA1. However, in pancreatic adenocarcinoma cells, the process is different: downregulating TRPA1 with siRNA, decreased cellular viability, and possibly, apoptosis, as revealed by cell cycle analysis [65]. These demonstrated that TRPA1 expression is important in the proliferation and apoptosis of pancreatic ductal adenocarcinoma cells without activation with specific agonists.…”

Section: Apoptosis Induced By Modulation Of the Redox Trp Channelsmentioning

confidence: 98%

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TRP Channels in Tumoral Processes Mediated by Oxidative Stress and Inflammation

Piciu,

Balas,

Badea

et al. 2023

Antioxidants

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The channels from the superfamily of transient receptor potential (TRP) activated by reactive oxygen species (ROS) can be defined as redox channels. Those with the best exposure of the cysteine residues and, hence, the most sensitive to oxidative stress are TRPC4, TRPC5, TRPV1, TRPV4, and TRPA1, while others, such as TRPC3, TRPM2, and TRPM7, are indirectly activated by ROS. Furthermore, activation by ROS has different effects on the tumorigenic process: some TRP channels may, upon activation, stimulate proliferation, apoptosis, or migration of cancer cells, while others inhibit these processes, depending on the cancer type, tumoral microenvironment, and, finally, on the methods used for evaluation. Therefore, using these polymodal proteins as therapeutic targets is still an unmet need, despite their draggability and modulation by simple and mostly unharmful compounds. This review intended to create some cellular models of the interaction between oxidative stress, TRP channels, and inflammation. Although somewhat crosstalk between the three actors was rather theoretical, we intended to gather the recently published data and proposed pathways of cancer inhibition using modulators of TRP proteins, hoping that the experimental data corroborated clinical information may finally bring the results from the bench to the bedside.

show abstract

Section: Redox Trp Channels and Inflammationsupporting

confidence: 79%

Section: Apoptosis Induced By Modulation Of the Redox Trp Channelsmentioning

confidence: 98%

TRP Channels in Tumoral Processes Mediated by Oxidative Stress and Inflammation

Piciu,

Balas,

Badea

et al. 2023

Antioxidants

Self Cite

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TRP Channels in Tumoral Processes Mediated by Oxidative Stress and Inflammation: Friends or Foes?

Piciu,

Balas,

Badea

et al. 2023

Preprint

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The channels from the superfamily of transient receptor potential (TRP) activated by reactive oxygen species (ROS) are defined as redox channels. Those with the best exposure of the cysteine residues and hence the most sensitive to oxidative stress are TRPC4, TRPC5, TRPV1, TRPV4, and TRPA1, while others, such as TRPM2 and TRPM7 are indirectly activated by ROS. Activation by ROS has different effects on the tumorigenic process: some TRP channels may, upon activation, stimulate proliferation, apoptosis, or migration of cancer cells, while others inhibit these processes, depending on the cancer type, tumoral microenvironment and finally on the methods used for evaluation. Therefore, the use of these polymodal proteins as therapeutic targets is still an unmet need, despite their draggability and modulation by simple and mostly unharmful compounds. In this review, we intend to create some cellular models of the interaction between oxidative stress, TRP channels, and inflammation. Although the crosstalk between the three actors is rather theoretical, we intended to gather the recently published data and proposed pathways of cancer inhibition using modulators of TRP proteins, hoping that the experimental data corroborated with clinical information may finally bring the results from the bench to the bedside.

show abstract

Publisher Correction: Functional expression of the transient receptor potential ankyrin type 1 channel in pancreatic adenocarcinoma cells

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Cited by 2 publications

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TRP Channels in Tumoral Processes Mediated by Oxidative Stress and Inflammation

TRP Channels in Tumoral Processes Mediated by Oxidative Stress and Inflammation

TRP Channels in Tumoral Processes Mediated by Oxidative Stress and Inflammation: Friends or Foes?

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