Publisher Correction: Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus

Kraemer, Moritz U. G.; Reiner, Robert C.; Brady, Oliver J.; Messina, Jane P.; Gilbert, Marius; Pigott, David M.; Yi, Dingdong; Johnson, Kimberly; Earl, Lucas; Marczak, Laurie B.; Shirude, Shreya; Weaver, Nicole Davis; Bisanzio, Donal; Perkins, T. Alex; Lai, Shengjie; Lü, Xin; Jones, Peter G.; Coelho, Giovanini Evelim; Carvalho, Roberta Gomes; Bortel, Wim Van; Marsboom, Cedric; Hendrickx, Guy; Schaffner, Francis; Moore, Chester G.; Nax, Heinrich H.; Bengtsson, Linus; Wetter, Erik; Tatem, Andrew J.; Brownstein, John S.; Smith, David L.; Lambrechts, Louis; Cauchemez, Simon; Linard, Catherine; Faria, Nuno R.; Pybus, Oliver G.; Scott, Thomas W.; Liu, Qiyong; Yu, Hong-jie; Wint, G. R. William; Hay, Simon I.; Golding, Nick

doi:10.1038/s41564-019-0440-7

Cited by 24 publications

(19 citation statements)

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“…Dengue virus (DENV) is one of the most significant arthropod-borne viruses (arbovirus) with respect to disease burden in humans, causing ~390 million new infections each year worldwide ( Bhatt et al, 2013 ). DENV is primarily spread by the female mosquitoes Aedes aegypti and Aedes albopictus , which are two vectors characterized by rapidly expanding geographic distributions throughout the world ( Kraemer et al, 2019 ; Lambrechts et al, 2010 , 2011 ). As a consequence of human activities and environmental changes that favor mosquito vectors, over the next 30–50 years, DENV infection incidence rates are also projected to increase in frequency in locations where it is currently endemic and also spread to new parts of the world ( Kraemer et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

“…DENV is primarily spread by the female mosquitoes Aedes aegypti and Aedes albopictus, which are two vectors characterized by rapidly expanding geographic distributions throughout the world (Kraemer et al, 2019;Lambrechts et al, 2010Lambrechts et al, , 2011. As a consequence of human activities and environmental changes that favor mosquito vectors, over the next 30-50 years, DENV infection incidence rates are also projected to increase in frequency in locations where it is currently endemic and also spread to new parts of the world (Kraemer et al, 2019). DENV is classified into four serotypes, which include DENV serotype 1 (DENV1), DENV2, DENV3, and DENV4.…”

Section: Introductionmentioning

confidence: 99%

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Antigenic Variation of the Dengue Virus 2 Genotypes Impacts the Neutralization Activity of Human Antibodies in Vaccinees

et al. 2020

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SUMMARY Dengue virus (DENV) infects an estimated 390 million people each year worldwide. As tetravalent DENV vaccines have variable efficacy against DENV serotype 2 (DENV2), we evaluated the role of genetic diversity within the pre-membrane (prM) and envelope (E) proteins of DENV2 on vaccine performance. We generated a recombinant DENV2 genotype variant panel with contemporary prM and E isolates that are representative of global genetic diversity. The DENV2 genotype variants differ in growth kinetics, morphology, and virion stability. Importantly, the DENV2 genotypic variants are differentially neutralized by monoclonal antibodies, polyclonal serum neutralizing antibodies from DENV2-infected human subjects, and vaccine-elicited antibody responses from the TV003 NIH DENV2 monovalent and DENV tetravalent vaccines. We conclude that DENV2 prM and E genetic diversity significantly modulates antibody neutralization activity. These findings have important implications for dengue vaccines, which are being developed under the assumption that intraserotype variation has minimal impact on neutralizing antibodies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antigenic Variation of the Dengue Virus 2 Genotypes Impacts the Neutralization Activity of Human Antibodies in Vaccinees

et al. 2020

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“…Similar dispersal behavior can produce similar patterns of differentiation ( 76 ). Mosquitoes spread from south to north through active dispersal affected by global warming and passive dispersal caused by human activities ( 77 – 80 ). This also explains the reports of some dengue cases in new non-endemic areas in recent years ( 62 , 81 ).…”

Section: Discussionmentioning

confidence: 99%

Genome-wide SNPs reveal novel patterns of spatial genetic structure in Aedes albopictus (Diptera Culicidae) population in China

He²,

Wang³

et al. 2022

Front. Public Health

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IntroductionSince the second half of the 20th century, Aedes albopictus, a vector for more than 20 arboviruses, has spread worldwide. Aedes albopictus is the main vector of infectious diseases transmitted by Aedes mosquitoes in China, and it has caused concerns regarding public health. A comprehensive understanding of the spatial genetic structure of this vector species at a genomic level is essential for effective vector control and the prevention of vector-borne diseases.MethodsDuring 2016–2018, adult female Ae. albopictus mosquitoes were collected from eight different geographical locations across China. Restriction site-associated DNA sequencing (RAD-seq) was used for high-throughput identification of single nucleotide polymorphisms (SNPs) and genotyping of the Ae. albopictus population. The spatial genetic structure was analyzed and compared to those exhibited by mitochondrial cytochrome c oxidase subunit 1 (cox1) and microsatellites in the Ae. albopictus population.ResultsA total of 9,103 genome-wide SNP loci in 101 specimens and 32 haplotypes of cox1 in 231 specimens were identified in the samples from eight locations in China. Principal component analysis revealed that samples from Lingshui and Zhanjiang were more genetically different than those from the other locations. The SNPs provided a better resolution and stronger signals for novel spatial population genetic structures than those from the cox1 data and a set of previously genotyped microsatellites. The fixation indexes from the SNP dataset showed shallow but significant genetic differentiation in the population. The Mantel test indicated a positive correlation between genetic distance and geographical distance. However, the asymmetric gene flow was detected among the populations, and it was higher from south to north and west to east than in the opposite directions.ConclusionsThe genome-wide SNPs revealed seven gene pools and fine spatial genetic structure of the Ae. albopictus population in China. The RAD-seq approach has great potential to increase our understanding of the spatial dynamics of population spread and establishment, which will help us to design new strategies for controlling vectors and mosquito-borne diseases.

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“…Global transmission of dengue virus (DENV) has become a significant public health concern over the past 40 years 1 . Almost half of the world’s population is now at risk of infection 2 , with over 390 million cases reported each year 3 .…”

Section: Introductionmentioning

confidence: 99%

Mechanical transmission of Dengue Virus byAedes aegyptimay influence disease transmission dynamics during outbreaks

et al. 2023

Preprint

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The escalating number of dengue virus (DENV) outbreaks and their worldwide spread pose a major threat to global public health. DENV transmission dynamics significantly influence outbreak duration and magnitude. Conventional DENV transmission requires an incubation period between mosquitoes biting infected humans and the mosquitoes becoming infectious. However, the possibility of immediate, mechanical transmission of DENV without viral replication in the mosquito has received little attention despite its potential importance. Here, we show that Aedes aegypti mosquitoes can mechanically transmit DENV to susceptible mice immediately after biting infected mice without the need for an incubation period. By incorporating parameters from our experiments into a newly developed mathematical model, we found a significant impact on DENV outbreak characteristics. Mechanical transmission may amplify existing disease transmission routes and influence outbreak dynamics. Our findings have implications for vector control strategies that target mosquito lifespan and suggest the possibility of similar mechanical transmission routes in other disease-carrying mosquitoes.

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Publisher Correction: Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus

Abstract: This Article was mistakenly not made Open Access when originally published; this has now been amended, and information about the Creative Commons Attribution 4.0 International License has been added into the ‘Additional information’ section.

Cited by 24 publications

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Antigenic Variation of the Dengue Virus 2 Genotypes Impacts the Neutralization Activity of Human Antibodies in Vaccinees

Antigenic Variation of the Dengue Virus 2 Genotypes Impacts the Neutralization Activity of Human Antibodies in Vaccinees

Genome-wide SNPs reveal novel patterns of spatial genetic structure in Aedes albopictus (Diptera Culicidae) population in China

Mechanical transmission of Dengue Virus byAedes aegyptimay influence disease transmission dynamics during outbreaks

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