Publisher Correction: Ultraviolet radiation–induced DNA damage is prognostic for outcome in melanoma

Trucco, Lucas D; Mundra, Piyushkumar A.; Hogan, Kate; García-Martínez, Pablo; Virós, Amaya; Mandal, Amit Kumar; Macagno, Nicolas; Gaudy‐Marqueste, C.; Allan, Donald; Baenke, Franziska; Cook, Martin; McManus, C.; Sánchez-Laorden, Berta; Dhomen, Nathalie; Marais, Richard

doi:10.1038/s41591-018-0325-y

Cited by 6 publications

(2 citation statements)

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“…An interesting output of this sequencing effort is the statistical analysis of the databank that made possible the determination of mutational signatures 193,194 available on-line from the COSMIC consortium 195 . Signatures bearing mutations at bipyrimidine sites (Table 7.2) are observed with a high frequency in melanoma 190,[196][197][198][199] , basal cell carcinoma 200,201 , squamous cell carcinoma 202 and cutaneous T cell lymphoma 203 . They are basically absent from other cancer types.…”

Section: Next Generation Sequencing Of Human Tumoursmentioning

confidence: 99%

CHAPTER 7. Ultraviolet-induced Formation of DNA Damage in Cells and their Mutational Consequences

Douki¹,

Adar²

2021

Comprehensive Series in Photochemical &Amp; Photobiological Sciences

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Ultraviolet radiation induces a wide variety of damage in DNA that can originate from either photochemical reaction triggered by absorption of photons by DNA bases or oxidation processes mostly induced by photosensitization. The nature of DNA damage is dependent of numerous factors such the wavelength, the sequence, the chromatin structure or the cell type. The present chapter provides a summary of the available quantitative information of the yield of UV-induced DNA damage as well as the most recent pieces of information bases on state-of-the-art techniques such as next generation sequencing. The mutational consequences of the DNA photoproducts are briefly discussed.

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Section: Next Generation Sequencing Of Human Tumoursmentioning

confidence: 99%

CHAPTER 7. Ultraviolet-induced Formation of DNA Damage in Cells and their Mutational Consequences

Douki¹,

Adar²

2021

Comprehensive Series in Photochemical &Amp; Photobiological Sciences

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“…Melanoma and lung cancer are the most mutated cancers [20], which is why patients suffering from these diseases benefit from immunotherapy to a higher extent than other cancer patients [21]. In melanoma, some UV-induced DNA damage is also prognostic for outcome [22].…”

Section: Tumor Mutational Burden (Tmb) As An Indicator For Predicting Response To Immunotherapymentioning

confidence: 99%

Biological Factors behind Melanoma Response to Immune Checkpoint Inhibitors

Olbryt

Rajczykowski

Widłak

2020

IJMS

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Modern immunotherapy together with targeted therapy has revolutionized the treatment of advanced melanoma. Inhibition of immune checkpoints significantly improved the median overall survival and gave hope to many melanoma patients. However, this treatment has three serious drawbacks: high cost, serious side effects, and an effectiveness limited only to approximately 50% of patients. Some patients do not derive any or short-term benefit from this treatment due to primary or secondary resistance. The response to immunotherapy depends on many factors that fall into three main categories: those associated with melanoma cells, those linked to a tumor and its microenvironment, and those classified as individual ontogenic and physiological features of the patient. The first category comprises expression of PD-L1 and HLA proteins on melanoma cells as well as genetic/genomic metrics such as mutational load, (de)activation of specific signaling pathways and epigenetic factors. The second category is the inflammatory status of the tumor: “hot” versus “cold” (i.e., high versus low infiltration of immune cells). The third category comprises metabolome and single nucleotide polymorphisms of specific genes. Here we present up-to-date data on those biological factors influencing melanoma response to immunotherapy with a special focus on signaling pathways regulating the complex process of anti-tumor immune response. We also discuss their potential predictive capacity.

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RETRACTED ARTICLE: MicroRNA-205-5p inhibits skin cancer cell proliferation and increase drug sensitivity by targeting TNFAIP8

Niture

Lin

et al. 2021

Sci Rep

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Tumor necrosis factor-α-induced protein 8 (TNFAIP8) is a member of the TIPE/TNFAIP8 family which regulates tumor growth and survival. Our goal is to delineate the detailed oncogenic role of TNFAIP8 in skin cancer development and progression. Here we demonstrated that higher expression of TNFAIP8 is associated with basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma development in patient tissues. Induction of TNFAIP8 expression by TNFα or by ectopic expression of TNFAIP8 in SCC or melanoma cell lines resulted in increased cell growth/proliferation. Conversely, silencing of TNFAIP8 decreased cell survival/cell migration in skin cancer cells. We also showed that miR-205-5p targets the 3′UTR of TNFAIP8 and inhibits TNFAIP8 expression. Moreover, miR-205-5p downregulates TNFAIP8 mediated cellular autophagy, increased sensitivity towards the B-RAFV600E mutant kinase inhibitor vemurafenib, and induced cell apoptosis in melanoma cells. Collectively our data indicate that miR-205-5p acts as a tumor suppressor in skin cancer by targeting TNFAIP8.

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Publisher Correction: Ultraviolet radiation–induced DNA damage is prognostic for outcome in melanoma

Abstract: In the version of this article originally published, Extended Data Fig. 3 was incorrect. A duplicate of Extended Data Fig. 4 was uploaded in place of Extended Data Fig. 3. Extended Data Fig. 3 has now been uploaded. The error has been fixed in the PDF and HTML versions of this article.

Cited by 6 publications

References 0 publications

CHAPTER 7. Ultraviolet-induced Formation of DNA Damage in Cells and their Mutational Consequences

CHAPTER 7. Ultraviolet-induced Formation of DNA Damage in Cells and their Mutational Consequences

Biological Factors behind Melanoma Response to Immune Checkpoint Inhibitors

RETRACTED ARTICLE: MicroRNA-205-5p inhibits skin cancer cell proliferation and increase drug sensitivity by targeting TNFAIP8

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