Pudendal Nerve Terminal Motor Latency in Women with Genuine Stress Incontinence and Prolapse

Bakas, Panagiotis; Liapis, Angelos; Karandreas, A.; Creatsas, G.

doi:10.1159/000052922

Cited by 21 publications

(8 citation statements)

References 16 publications

(19 reference statements)

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“…Increased PF activity has previously been reported in a subgroup of women with incontinence, 5,38 and may represent a compensation mechanism to control, or moderate, symptoms. 24 Although, maximal urethral closure pressure has been shown to be decreased in women with incontinence, 39,40 the effect of PF activity on urethral closure at rest 8 and during functional tasks is unclear.…”

Section: Muscle Activity In Continent and Incontinent Womenmentioning

confidence: 99%

Postural response of the pelvic floor and abdominal muscles in women with and without incontinence

Smith

Coppieters

Hodges

2007

Neurourology and Urodynamics

155

139

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These data suggest that women with incontinence have increased PF and abdominal muscle activity associated with postural perturbations. This finding challenges the clinical assumption that incontinence is associated with reduced PF muscle activity, and suggests that training control and coordination of abdominal muscle activity may be important in treatment of this condition. The contrasting effects of increased bladder volume on PF and abdominal muscle EMG are likely to present further challenges to the maintenance of continence.

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Section: Muscle Activity In Continent and Incontinent Womenmentioning

confidence: 99%

Postural response of the pelvic floor and abdominal muscles in women with and without incontinence

Smith

Coppieters

Hodges

2007

Neurourology and Urodynamics

155

139

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“…This approach owes its popularity to a number of studies reporting prolonged TMLs in various anorectal disorders, 101,121 such as fecal incontinence, 18,48,58,62,94,120,129,130,142,150,162,166 obstetrical lesions, 141,144,146,152,153,155 perineal descent, 6,51,53,62,77,143 or even constipation. 162,163 Evidence of pudendal/ anal neuropathy, as shown by a prolonged TML, was proposed as a predictive factor for the clinical outcome of biofeedback therapy 67 or surgical repair 13,39,145 of pelvic floor disturbances, even in case of unilateral neuropathy.…”

Section: Terminal Motor Latency Measurementmentioning

confidence: 99%

Neurophysiological testing in anorectal disorders

Lefaucheur

2005

Muscle and Nerve

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The neurophysiological techniques currently available to evaluate anorectal disorders include concentric needle electromyography (EMG) of the external anal sphincter, anal nerve terminal motor latency (TML) measurement in response to transrectal electrical stimulation or sacral magnetic stimulation, motor evoked potentials (MEPs) of the anal sphincter to transcranial magnetic cortical stimulation, cortical recording of somatosensory evoked potentials (SEPs) to anal nerve stimulation, quantification of electrical or thermal sensory thresholds (QSTs) within the anal canal, sacral anal reflex (SAR) latency measurement in response to pudendal nerve or perianal stimulation, and perianal recording of sympathetic skin responses (SSRs). In most cases, a comprehensive approach using several tests is helpful for diagnosis: needle EMG signs of sphincter denervation or prolonged TML give evidence for anal motor nerve lesion; SEP/QST or SSR abnormalities can suggest sensory or autonomic neuropathy; and in the absence of peripheral nerve disorder, MEPs, SEPs, SSRs, and SARs can assist in demonstrating and localizing spinal or supraspinal disease. Such techniques are complementary to other methods of investigation, such as pelvic floor imaging and anorectal manometry, to establish the diagnosis and guide therapeutic management of neurogenic anorectal disorders.

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“…delancey (11) proposed that Pn injury causes denervation of pelvic floor muscles. Previous studies of pelvic floor electromyography of patients with SUI, nerve conduction velocity, pelvic floor muscle pathology and neurofibrillary immunohistochemical staining have also demonstrated that pelvic denervation is present in patients with Sui (9,30,31).…”

Section: Discussionmentioning

confidence: 91%

Effects of electrical stimulation on cell activity, cell cycle, cell apoptosis and β‑catenin pathway in the injured dorsal root ganglion cell

et al. 2020

Mol Med Report

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The present study aimed to investigate the effects of electrical stimulation (eS) on cell activity, cell cycle and apoptosis in injured rat dorsal root ganglion (drG) cells induced by cyclic mechanical stretching (cMS). The present study also investigated whether the Wnt/β-catenin pathway is involved in this process. injury and eS models were established in drG cells. Then, cell activity was detected using a cell counting Kit-8 and 5-ethynyl-2'-deoxyuridine-594 cell proliferation assay kit. cell cycle distribution was detected using a cell cycle detection kit. apoptosis was detected using an annexin V-FiTc apoptosis detection kit, and Wnt/β-catenin pathway-associated proteins were detected using western blotting. The present study demonstrated that cMS decreased drG cell activity, increased the number of cells in the S phase, promoted cell apoptosis and inhibited the Wnt/β-catenin pathway. in addition, eS significantly increased the proliferation activity of drG cells, increased the number of cells in the G2 phase, decreased the apoptotic rate and activated the Wnt/β-catenin pathway, ultimately reversing the injury caused by cMS. Following inhibition of the Wnt/β-catenin signaling pathway using XaV939, the effects of eS were weakened. in conclusion, the present study demonstrated that eS may reverse cMS-induced injury in drG cells, and that the Wnt signaling pathway may be involved in this process.

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Pudendal Nerve Terminal Motor Latency in Women with Genuine Stress Incontinence and Prolapse

Cited by 21 publications

References 16 publications

Postural response of the pelvic floor and abdominal muscles in women with and without incontinence

Postural response of the pelvic floor and abdominal muscles in women with and without incontinence

Neurophysiological testing in anorectal disorders

Effects of electrical stimulation on cell activity, cell cycle, cell apoptosis and β‑catenin pathway in the injured dorsal root ganglion cell

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