Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells

Suppressive Effects of Puerariae Radix on the Breast Tumor Incidence in Rats Treated with DMBA

“…Although PR isoflavones and their metabolites have previously been shown to modulate the growth of breast cancer in vitro (Lin et al, 2009), this is the first study to investigate these effects in vivo to the best of our knowledge. The present study showed that the incidence of breast tumors decreased significantly following PR administration in a DMBA-induced breast tumor model.…”

“…Recent pharmacological research has demonstrated that puerarin, a major isoflavone glycoside of PR, exhibits a wide range of biological activities including protective effects in ischemic myocardial injury , inflammation , and oxidation (Ma et al, 2014;Wang et al, 2016). In addition, previous studies have indicated that pretreatment with Pueraria mirifica (another species of Pueraria) decreases breast tumor incidence in vivo (Cherdshewasart et al, 2007), and that PR isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cell lines (Lin et al, 2009). However, the mechanism behind the protective effects of PR against breast tumorigenesis in animal models remains unclear.…”

Effects of a surface topography composite with puerariae radix on human STRO-1-positive stem cells

“…Isoflavones such as puerarin, daidzin, and daidzein are commonly regarded as phytoestrogens found in PR owing to their estrogenic activity in certain animal models (61,62). Results from cell cycle distribution indicated that isoflavones from puerariae radix mediated cell cycle arrest in the G2/M phase (63). The study of estrogen (17β-Estradiol) treatment on osteoblastic MBA-15 cells derived from marrow stromal origin resulted in reduction in expression of tubulin (64) as found in this study (7-fold).…”

Potent genistein derivatives as inhibitors of estrogen receptor alpha-positive breast cancer

“…Isoflavones such as genistein and daidzein inhibit growth and induce apoptosis in breast cancer cells. 6,21 Similar growth-inhibitory effects of various isoflavones were also seen in ER-positive pancreatic cancer cells. 11,22 It has been reported that genistein can inhibit cancer cell growth, 16 induce apoptotic cell death and cell cycle arrest at the G 2 -M phase, 12,17,23 depending on cell types.…”