Puerarin, isolated from Pueraria lobata (Willd.), protects against hepatotoxicity via specific inhibition of the TGF-β1/Smad signaling pathway, thereby leading to anti-fibrotic effect

Xu, Lingyuan; Zheng, Na; He, Qiaoling; Li, Rong; Zhang, Kefeng; Liang, Tao

doi:10.1016/j.phymed.2013.06.008

Cited by 46 publications

(33 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The fibrosis rat preparation was conducted as previously described with some amendments [17]. Briefly, 80 male rats were randomly assigned into four groups (n=20, each group).…”

Section: Animals and Plumbagin Deliverymentioning

confidence: 99%

Anti-Fibrotic Effect of Plumbagin on CCl4-Lesioned Rats

Wei

Huang

Liu

et al. 2015

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Our previous studies have shown that plumbagin effectively inhibits hepatic stellate cell (HSC) proliferation. Thus, plumbagin-mediated anti-fibrotic effects in vivo merit further investigation. Methods: We used rat models to assess the potential benefits of plumbagin against CCl₄-induced liver fibrosis. Results: The results showed that plumbagin lowered the serum concentrations of liver functional enzymes (ALT, AST, ALB, TBIL) in CCl₄-fibrotic rats while reducing inflammatory cytokine levels (IL-6, TNF-a). As reflected in pathological examinations, rats that were administered plumbagin showed decreased collagen markers (HA, LN, PCIII and CIV) in liver tissues and improved hepatocellular impairments. In addition, plumbagin contributed to down-regulating NF-κB and TLR-4 mRNA in CCl₄-lesioned livers. As revealed in the immunohistochemical assay, plumbagin-administered rats showed reduced levels of a-SMA and TNF-a immunoreactive cells in liver tissue. Conclusion: Collectively, these findings offer appealing evidence that plumbagin may serve as an anti-fibrotic medication through inactivating the NF-κB/TLR-4 pathway that is associated with inflammatory reactions, thereby mitigating liver fibrosis.

show abstract

“…The fibrosis rat preparation was conducted as previously described with some amendments [17]. Briefly, 80 male rats were randomly assigned into four groups (n=20, each group).…”

Section: Animals and Plumbagin Deliverymentioning

confidence: 99%

Anti-Fibrotic Effect of Plumbagin on CCl4-Lesioned Rats

Wei

Huang

Liu

et al. 2015

Cell Physiol Biochem

View full text Add to dashboard Cite

show abstract

“…A variety of cytokines, inflammatory mediators, and genetic factors contribute to the process of tissue fibrosis [10][11][12]. High mobility group box 1 (HMGB1), a highly conserved DNA-binding protein, is an important therapeutic target for several diseases [13,14].…”

Section: Introductionmentioning

confidence: 99%

Total glycosides of Yupingfeng protects against bleomycin-induced pulmonary fibrosis in rats associated with reduced high mobility group box 1 activation and epithelial–mesenchymal transition

Cui

et al. 2015

Inflamm. Res.

View full text Add to dashboard Cite

show abstract

“…10,11 Puerarin (daidzein-8-C-glucoside) is the main isoflavone isolated from the Chinese medicinal herb Ge-gen, the root of the wild leguminous creeper Pueraria lobata (kudzu root). 12 It has been shown effective in the treatment of kidney diseases, such as nephrotoxicity, acute kidney injury and nephropathy. [13][14][15][16] The possible mechanisms by which Puerarin exerts its protective effects, at least in part, are related to its ability to increase superoxide dismutase activity, decrease the lipid peroxidation level and enhance fibrinolysis.…”

Section: Introductionmentioning

confidence: 99%

The Puerarin improves renal function in STZ-induced diabetic rats by attenuating eNOS expression

Zhang

Wang

et al. 2015

Renal Failure

View full text Add to dashboard Cite

Diabetic nephropathy (DN) is a serious complication and it leads to kidney failure. The endothelial nitric oxide synthases (eNOS) seems to be involved in the development and progression of DN. The Puerarin is a well-known Chinese traditional formula, which is widely used in clinical practice for the treatment of kidney disease. The present study was designed to investigate the renal protective effects of Puerarin on streptozotocin (STZ)-induced diabetic rats. Thirty Sprague-Dawley (SD) male rats were divided into three groups at random. The diabetic group and the Puerarin-treated group were intraperitoneally injected with STZ 65 mg/kg and the Puerarin-treated rats were intraperitoneally injected Puerarin 100 mg/kg/day for 4 weeks. The results showed the Puerarin could improve body weight, blood sugar, BUN and SCr levels, and reduce ultrastructural changes of kidney in diabetic rats. It also attenuated eNOS expression in glomerular endothelial cells and tubular cells of diabetic rats with Puerarin treatment (p50.05). The Puerarin had significant renal-protective effects for the diabetic nephropathy, possibly through regulating eNOS expression, and it may be used as a potential therapeutic reagent.

show abstract

Puerarin, isolated from Pueraria lobata (Willd.), protects against hepatotoxicity via specific inhibition of the TGF-β1/Smad signaling pathway, thereby leading to anti-fibrotic effect

Cited by 46 publications

References 31 publications

Anti-Fibrotic Effect of Plumbagin on CCl4-Lesioned Rats

Anti-Fibrotic Effect of Plumbagin on CCl4-Lesioned Rats

Total glycosides of Yupingfeng protects against bleomycin-induced pulmonary fibrosis in rats associated with reduced high mobility group box 1 activation and epithelial–mesenchymal transition

The Puerarin improves renal function in STZ-induced diabetic rats by attenuating eNOS expression

Contact Info

Product

Resources

About