Puerarin-V prevents the progression of hypoxia- and monocrotaline-induced pulmonary hypertension in rodent models

Chen, Di; Zhang, Huifang; Yuan, Tianyi; Sun, Shuchan; Wang, Ranran; Wang, Shoubao; Fang, Lian-Hua; Lyu, Yang; Du, Guanhua

doi:10.1038/s41401-022-00865-y

Cited by 10 publications

(3 citation statements)

References 52 publications

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“…The mechanism may be closely related to the inhibition of oxidative stress and activation of the BMPRII/Smad and peroxisome proliferator-activated receptor γ (PPARγ)/PI3K/Akt signaling pathways [ 77 ]. A novel crystal type V (Puer-V) was found to have a better therapeutic effect than the crude form of puerarin, effectively alleviating abnormal structural changes and dysfunction in lung tissue and the right ventricle [ 78 ]. Puerarin also exhibited anti-inflammatory properties in rats with acute lung injury by modulating the renin–angiotensin system and NF-κB signaling pathway, modulating the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing-3 (NLRP3) inflammasome-induced pyroptosis, and reducing TNF-α, interleukin-6 (IL-6), and interleukin-1β (IL-1β) production [ 79 , 80 , 81 ].…”

Section: Natural Products For the Treatment Of Phmentioning

confidence: 99%

Natural Products for the Treatment of Pulmonary Hypertension: Mechanism, Progress, and Future Opportunities

Zeng

Wang

Cui

et al. 2023

CIMB

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Pulmonary hypertension (PH) is a lethal disease due to the remodeling of pulmonary vessels. Its pathophysiological characteristics include increased pulmonary arterial pressure and pulmonary vascular resistance, leading to right heart failure and death. The pathological mechanism of PH is complex and includes inflammation, oxidative stress, vasoconstriction/diastolic imbalance, genetic factors, and ion channel abnormalities. Currently, many clinical drugs for the treatment of PH mainly play their role by relaxing pulmonary arteries, and the treatment effect is limited. Recent studies have shown that various natural products have unique therapeutic advantages for PH with complex pathological mechanisms owing to their multitarget characteristics and low toxicity. This review summarizes the main natural products and their pharmacological mechanisms in PH treatment to provide a useful reference for future research and development of new anti-PH drugs and their mechanisms.

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Section: Natural Products For the Treatment Of Phmentioning

confidence: 99%

Natural Products for the Treatment of Pulmonary Hypertension: Mechanism, Progress, and Future Opportunities

Zeng

Wang

Cui

et al. 2023

CIMB

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“…In two experimental PH rodent models, puerarin had a significant protective effect characterized by right ventricular systolic pressure (RVSP) and lung injury, improvement of pulmonary artery blood flow, improvement of pulmonary vascular diastolic and systolic function, inhibition of inflammation of lung tissue, improvement of the resistance of lung tissue to apoptosis and abnormal proliferation, and alleviation and reconstitution of right ventricular injury to maintain the normal function of the right ventricle. MCT and hypoxia significantly down-regulated BMPR2/Smad signaling in lung tissue and PPARγ/PI3K/Akt signaling in lung tissue and the right ventricle, which were renovated by puerarin therapy [ 98 ].…”

Section: The Role Of Puerarin In Inflammatory Diseasesmentioning

confidence: 99%

Pharmacological Activity, Pharmacokinetics, and Clinical Research Progress of Puerarin

Wang

et al. 2022

Antioxidants

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As a kind of medicine and food homologous plant, kudzu root (Pueraria lobata (Willd.) Ohwi) is called an “official medicine” in Chinese folk medicine. Puerarin is the main active component extracted from kudzu root, and its structural formula is 8-β-D-grapes pyranose-4, 7-dihydroxy isoflavone, with a white needle crystal; it is slightly soluble in water, and its aqueous solution is colorless or light yellow. Puerarin is a natural antioxidant with high health value and has a series of biological activities such as antioxidation, anti-inflammation, anti-tumor effects, immunity improvement, and cardio-cerebrovascular and nerve cell protection. In particular, for the past few years, it has also been extensively used in clinical study. This review focuses on the antioxidant activity of puerarin, the therapy of diverse types of inflammatory diseases, various new drug delivery systems of puerarin, the “structure-activity relationship” of puerarin and its derivatives, and pharmacokinetic and clinical studies, which can provide a new perspective for the puerarin-related drug research and development, clinical application, and further development and utilization.

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“…It was shown ( Li et al, 2020 ) that puerarin alleviates HO-stimulated EndMT in human coronary artery endothelial cells (HCAECs) by inhibiting ROS and activating PI3K/Akt pathway. Chen et al (2022) conducted a study using two animal models of pulmonary arterial hypertension (PAH), a rat model of monocrotaline (MCT)-induced PAH and a mouse model of hypoxia-induced hypoxic pulmonary hypertension (HPH). They confirmed that puerarin can effectively improve the structural and functional abnormalities of the pulmonary artery and right ventricle, and restore the PI3K/Akt pathway downregulated by MCT and hypoxia.…”

Section: Puerarin Regulates Pi3k/akt Signal Pathway To Protect the Ne...mentioning

confidence: 99%

Protective effects and mechanism of puerarin targeting PI3K/Akt signal pathway on neurological diseases

et al. 2022

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Neurological diseases impose a tremendous and increasing burden on global health, and there is currently no curative agent. Puerarin, a natural isoflavone extracted from the dried root of Pueraria montana var. Lobata (Willd.) Sanjappa and Predeep, is an active ingredient with anti-inflammatory, antioxidant, anti-apoptotic, and autophagy-regulating effects. It has great potential in the treatment of neurological and other diseases. Phosphatidylinositol 3-kinases/protein kinase B (PI3K/Akt) signal pathway is a crucial signal transduction mechanism that regulates biological processes such as cell regeneration, apoptosis, and cognitive memory in the central nervous system, and is closely related to the pathogenesis of nervous system diseases. Accumulating evidence suggests that the excellent neuroprotective effect of puerarin may be related to the regulation of the PI3K/Akt signal pathway. Here, we summarized the main biological functions and neuroprotective effects of puerarin via activating PI3K/Akt signal pathway in neurological diseases. This paper illustrates that puerarin, as a neuroprotective agent, can protect nerve cells and delay the progression of neurological diseases through the PI3K/Akt signal pathway.

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Puerarin-V prevents the progression of hypoxia- and monocrotaline-induced pulmonary hypertension in rodent models

Cited by 10 publications

References 52 publications

Natural Products for the Treatment of Pulmonary Hypertension: Mechanism, Progress, and Future Opportunities

Natural Products for the Treatment of Pulmonary Hypertension: Mechanism, Progress, and Future Opportunities

Pharmacological Activity, Pharmacokinetics, and Clinical Research Progress of Puerarin

Protective effects and mechanism of puerarin targeting PI3K/Akt signal pathway on neurological diseases

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