Puerperal Fever

Lash, A.F.; Kaplan, Bertha

doi:10.1001/jama.1926.02670420021005

Cited by 11 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is, however, to be noted that many observers have found that haemolytic streptococci recovered from various forms of infection are capable of elaborating "toxic" substances when grown in broth (2,3,4,5,6,7,8,9,10,11).…”

mentioning

confidence: 99%

Skin Reactions to Filtrates of Haemolytic Streptococci in Acute and Subacute Nephritis 1

Hansen-Pruss¹,

Longcope²,

O'Brien³

1929

J. Clin. Invest.

View full text Add to dashboard Cite

mentioning

confidence: 99%

Skin Reactions to Filtrates of Haemolytic Streptococci in Acute and Subacute Nephritis 1

Hansen-Pruss¹,

Longcope²,

O'Brien³

1929

J. Clin. Invest.

View full text Add to dashboard Cite

“…Other observers have noted that culture filtrates of non-scarlatinal streptococci may produce reactions similar to those yielded by culture filtrates of scarlatina strains (Rosenow, 1924(Rosenow, , 1926Paraf, 1925;Williams, 1925). Birkhaug (1925) has obtained toxic filtrates from erysipelas strains, and Lash and Kaplan (1926) from puerperal septicaemia strains. Eagles (1926) has reported that strains from erysipelas, puerperal fever, and other conditions produced toxic filtrates differing apparently from filtrates of S. scarlatinae only in that they were weaker.…”

Section: H0jaenwolytic Streptococlimentioning

confidence: 98%

The Specific Toxigenic Properties of Haemolytic Streptococci from Scarlatina and other Sources

Mclachlan

1927

J. Hyg.

View full text Add to dashboard Cite

1. Without exception, ninety-eight strains of haemolytic streptococci isolated from scarlet fever cases have been found to produce a toxic principle which in high dilutions is capable of evoking a cutaneous reaction in sus ceptible persons.2. A certain proportion of haemolytic streptococci from other sources possess a similar toxigenic property. In the majority of such cases this property is only weakly developed as judged by quantitative tests. In a few instances a “toxin” is produced which is equally active with that of scarlatina strains.3. Certain non-scarlatina strains produce “toxins” which evoke a cutane ous reaction both in known positive reactors and also in persons who do not react to a standard toxin from a scarlatina strain.4. In the majority of cases the toxins produced by scarlatina strains are neutralised by the scarlatina antitoxic sera at present being used for therapeutic purposes, but a certain proportion of such toxins are not in the neutralised5. The “toxins”produced by non-scaralation strains are in the majority of cases neutralised by the antitoxic sera.

show abstract

Puerperal Fever

Lash¹

1926

JAMA

View full text Add to dashboard Cite

of cells, and was a replica of the surface epiderm. Thus, those parts of the follicle which lay closer to the surface exhibited a most sharply and fully developed stratum granulosum ; if anything, a basal layer was better indicated here than on the surface. However, no prickle cells could be made out. In deeper portions of the follicle, there was a delicate, threadlike, hyaloid (but doubtless keratinous, chemically) zone lining the lumen of the hair follicle. Its wavy contour reminded one of the elastic membrane in arteries and perhaps of the cuticle-like lining of sweat ducts. It is regretted that none of the bulbs of follicles were included in these sections.Sebaceous Glands : These were most inconspicuous for a position like the scalp, although they might have been more fully represented if deeper portions had been available for study. As it was, only small groups of cells adjacent to the hair follicle could be found. Those that were exhibited appeared normal.Sweat Glands : Again, since the examination was restricted to the upper portions of the scalp, the deeper parts, such as the secreting coils, were not represented. Ducts, however, were numerous.The lumina were narrow and their lining cells plump and of normal appearance. Comment and Summary : No exceptions could be taken against the epiderm ; if anything, it appeared to be biologically more active than normal. The important changes were those of the hair shaft, together with the assumption of epiderm-1 ike qualities on the part of the sheath. The second significant feature was the hyperplasia of the capillaries and of the spin¬ dle cells around them ; but there was nothing to indicate whether this was a primary or secondary factor in the case. The same was true of the scarcity of sebaceous glands, but in this case the explanation was at hand in the form of the secondary atrophy of disuse.Supplementary Note : In subsequently cut sections, the lowermost portions of some hair follicles were presented for study. Now the whole follicle was less than half the size of those elsewhere, and easily overlooked. The peripheral parts of the sheath merged with the surrounding loose fibrous tissue by reason of an edema, which affected both of these members. The sheath consisted of only two or three layers of cells, the basal ones not being recognizable as such. The center of the follicle consisted of some pink, probably keratinous substance, enclosing numerous epithelial nuclei. The latter were degenerate-some were swollen and pale, while others were shriveled, solid and almost black. Small numbers of lymphocytes and one or two polymorphonuclears appeared in the neighborhood of these follicles. The appear¬ ance was not that of an inflammation and fibrosis which was inducing an atrophy of the follicle, but more that of a primary atrophy. The surrounding loose fibrous tissue and minor cellular infiltrate might be interpreted as reactions to disin¬ tegration products of the hair shaft that were once present.The histologie diagnosis was atrophy of the hair follicle and seba...

show abstract

Puerperal Fever

Cited by 11 publications

References 2 publications

Skin Reactions to Filtrates of Haemolytic Streptococci in Acute and Subacute Nephritis 1

Skin Reactions to Filtrates of Haemolytic Streptococci in Acute and Subacute Nephritis 1

The Specific Toxigenic Properties of Haemolytic Streptococci from Scarlatina and other Sources

Puerperal Fever

Contact Info

Product

Resources

About