Pullulan: A versatile coating agent for superparamagnetic iron oxide nanoparticles

Coseri, Sergiu; Spatareanu, Alina; Săcărescu, Liviu; Socoliuc, Vlad; Stratulat, Ioan Sorin; Harabagiu, Valeria

doi:10.1002/app.42926

Cited by 17 publications

(10 citation statements)

References 25 publications

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“…One convenient way to generate cellulose derivatives that are able to be processed in water, comprise of the introduction of plenty carboxyl groups which could be done by simultaneously modifying the three –OH groups in the anhydroglucose unit, as we had previously reported [11,20]. Conversely, pullulan exhibits an excellent solubility in water, being suitable for reactions in the homogeneous media [4,5,10]. The oxidation reaction performed on pullulan employing the TEMPO-mediated protocol, allow the formation of 6-carboxy pullulan, which is even more water-soluble than the original pullulan [21].…”

Section: Resultsmentioning

confidence: 99%

“…Polysaccharides especially have gained a lot of consideration due to their abundance and renewability, being used in their native form or as a specific derivative. For example, the oxidation of polysaccharides represent one of the most suitable approaches to introduce new functionalities, i.e., aldehyde, ketone or carboxylic [2,3,4,5], that are able to serve for further derivatisation or as anchoring sites of different molecules, broadening the applications area of these products [6,7,8,9]. In our very recent studies, we have reported the preparation and characterization of oxidized cellulose (or oxidized pullulan)—PVA hydrogels with different content of oxidized polysaccharides [10,11].…”

Section: Introductionmentioning

confidence: 99%

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Physical Hydrogels of Oxidized Polysaccharides and Poly(Vinyl Alcohol) for Wound Dressing Applications

et al. 2019

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Two natural polymers, i.e., cellulose and water soluble pullulan, have been selectively oxidized employing the TEMPO-mediated protocol, to allow the introduction of C6-OOH groups. Thereafter, the composite hydrogels of poly(vinyl alcohol) (PVA) and different content of the oxidized polysaccharides were prepared by the freezing/thawing method. The Fourier transform infrared spectroscopy (FTIR) has been used to discuss the degree of interaction between the hydrogels constituents into the physical network. The homogeneity of the prepared hydrogels as revealed by the SEM show an excellent distribution of the oxidized polysaccharides inside the PVA matrix. The samples exhibit self-healing features, since they quickly recover the initial structure after being subjected to a large deformation. The cell viability was performed for the selected hydrogels, all of them showing promising results. The samples are able to load L-arginine both by physical phenomena, such as diffusion, and also by chemical phenomena, when imine-type bonds are likely to be formed. The synergism between the two constituents, PVA and oxidized polysaccharides, into the physical network, propose these hydrogels for many other biomedical applications.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Physical Hydrogels of Oxidized Polysaccharides and Poly(Vinyl Alcohol) for Wound Dressing Applications

et al. 2019

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“…Thus, the passivation and stabilization of synthesized magnetic NPs are important challenges. One of the methods for stabilization of magnetic NP is the modification of their surface by organic (low‐molecular or high‐molecular) or inorganic (silica, gold) substances 14,15 . The use of surface modifiers allows preventing magnetite NP aggregation, to control NP size and provides the immobilization onto NP surface of diverse ligands to increase NP surface compatibility with various materials.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and properties of magnetite nanoparticles with peroxide‐containing polymer shell and nanocomposites based on them

Serdiuk

Shevchuk

Bukartyk

et al. 2021

J of Applied Polymer Sci

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Magnetite nanoparticles (Fe3O4 NPs) with peroxide‐containing polymer shell have been synthesized using the method of coprecipitation from the mixture solutions of Fe (II) and Fe (III) salts in the presence of peroxide‐containing copolymer (PCC). Polymer shell presence has been proved by elemental and complex thermal analysis. Synthesized Fe3O4 NPs possess superparamagnetic properties. Their specific saturation magnetization decreases gradually from 65 to 54 A·m2·kg−1 with increasing PCC concentration owing to the surface spin pinning effect caused by a polymer shell. The average sizes of Fe3O4 NPs estimated from the data of XRD analysis and magnetic measurements are in the range of 9–12 nm. The NP sizes determined by the DLS method lie in the range of 150–270 nm; this result is significantly larger than the sizes estimated by the two aforementioned methods evidencing a tendency for Fe3O4 NPs toward self‐association. Cross‐linked composite films based on polyvinyl alcohol have been obtained via radical curing initiated by the PCC shell of nanoparticles. The resulting composite films are magnetically sensitive films with rather high physico‐mechanical properties (tensile strength reaches 48–67 MPa and relative elongation – 4%–21% depending on cross‐linking degree), a priori non‐toxic and biocompatible, which makes them promising materials for various applications.

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“…Several pullulan derivatives have been investigated for biomedical applications such as poly(DL-lactide-co-glycolide)-grafted pullulan, cholesterol-bearing pullulan, pullulan acetate, perfluoroalkylated pullulan, etc. Pullulan and its derivatives are used in tissue engineering and drug delivery systems due to their excellent physicochemical properties [8,9].…”

Section: Introductionmentioning

confidence: 99%

Preliminary Evaluation of Pullulan Nanoparticles Loaded with Valsartan

Păvăloiu

Sha’at

Hlevca

et al. 2020

The 24th International Electronic Conference on Synthetic Organic Chemistry

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The objective of this paper is to develop polymeric nanoparticles loaded with a cardiovascular drug, an angiotensin II receptor antagonist drug, valsartan. Polymeric nanoparticles were prepared via nanoprecipitation method using pullulan acetate as biodegradable polymeric matrix and Pluronic F127 as a stabilizer. Pullulan acetate was obtained by chemical modification of pullulan (produced through a fermentation process by Aureobasidium pullulans strain) with dimethylformamide, pyridine, and acetic anhydride. Obtained nanoparticles were characterized in terms of entrapment efficiency, size, and polydispersity index using spectrophotometric and dynamic light scattering techniques. The valsartan-loaded nanoparticles showed a good entrapment efficiency of valsartan, nano-metric sizes (lower than 200 nm), and a narrow dispersity (polydispersity index below 0.2). This research revealed that pullulan and pullulan derivatives showed great potential for the production of nanoparticles with application in cardiovascular agents delivery.

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Pullulan: A versatile coating agent for superparamagnetic iron oxide nanoparticles

Cited by 17 publications

References 25 publications

Physical Hydrogels of Oxidized Polysaccharides and Poly(Vinyl Alcohol) for Wound Dressing Applications

Physical Hydrogels of Oxidized Polysaccharides and Poly(Vinyl Alcohol) for Wound Dressing Applications

Synthesis and properties of magnetite nanoparticles with peroxide‐containing polymer shell and nanocomposites based on them

Preliminary Evaluation of Pullulan Nanoparticles Loaded with Valsartan

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