Pullulan-based Nanoparticles: Future Therapeutic Applications in Transmucosal Protein Delivery

Grenha, Ana; Rodrigues, Susana

doi:10.4155/tde.13.99

Cited by 27 publications

(7 citation statements)

References 17 publications

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“…Several advantages have been experimentally reported about pullulans that make them suitable for drug delivery applications such as ability to adhere and form fibres as well as thin biodegradable films. Adhesion of pullulan‐based carriers to cell surfaces may be advantageous in drug/gene delivery applications with increasing the retention time and consequently allowing for timely absorption of the entrapped cargos . In addition, pullulan exhibits high affinity for asialoglycoprotein receptors overexpressed on hepatocyte cells and hence can be specifically internalized by hepatocytes through the receptor‐mediated endocytosis .…”

Section: Polysaccharide Nanoparticlesmentioning

confidence: 99%

Overviews on the cellular uptake mechanism of polysaccharide colloidal nanoparticles

Salatin

Khosroushahi

2017

J Cellular Molecular Medi

249

143

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Nanoparticulate drug/gene carriers have gained much attention in the past decades because of their versatile and tunable properties. However, efficacy of the therapeutic agents can be further enhanced using naturally occurring materials‐based nanoparticles. Polysaccharides are an emerging class of biopolymers; therefore, they are generally considered to be safe, non‐toxic, biocompatible and biodegradable. Considering that the target of nanoparticle‐based therapeutic strategies is localization of biomedical agents in subcellular compartments, a detailed understanding of the cellular mechanism involved in the uptake of polysaccharide‐based nanoparticles is essential for safe and efficient therapeutic applications. Uptake of the nanoparticles by the cellular systems occurs with a process known as endocytosis and is influenced by the physicochemical characteristics of nanoparticles such as size, shape and surface chemistry as well as the employed experimental conditions. In this study, we highlight the main endocytosis mechanisms responsible for the cellular uptake of polysaccharide nanoparticles containing drug/gene.

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Section: Polysaccharide Nanoparticlesmentioning

confidence: 99%

Overviews on the cellular uptake mechanism of polysaccharide colloidal nanoparticles

Salatin

Khosroushahi

2017

J Cellular Molecular Medi

249

143

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“…However, challenges with scalability have limited their utilization [127]. Natural polymers which have been explored include sodium alginate [128], pullulan [129], hyarulonic acid [130] and chondroitin sulfate [131].…”

Section: Double Emulsion Methodsmentioning

confidence: 99%

Solid-state Protein Formulations

et al. 2015

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When formulated as liquid dosage forms, therapeutic proteins and peptides often show instability during handling as a result of chemical degradation. Solid formulations are frequently required to maintain protein stability during storage, transport and upon administration. Herein we highlight current strategies used to formulate pharmaceutical proteins in the solid form. An overview of the physical instabilities which can arise with proteins is first described. The key solidification techniques of crystallization, freeze-drying and particle forming technologies are then discussed. Examples of current commercial products that are formulated in the solid state are provided and include neutral protamine Hagedorn - insulin crystal suspensions, freeze-dried monoclonal antibodies and leuproride polylactide-co-glycolide microparticles. Finally, future perspectives in solid-state protein formulation are described.

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“…Transmucosal delivery is the first-line option for the systemic delivery of many drugs and nanoparticles have been generally demonstrated to improve protein pharmacokinetic profiles, not only providing increased stabilization, but also allowing for controlled release and enhanced drug absorption. Pullulan-based nanoparticles have been reported to adhere to the nasal epithelium in a study regarding nasal vaccination [54], and the adherence of pullulan nanoparticles to respiratory epithelial cells, although to a limited extent, was verified [55].…”

Section: Pullulan and Nanotechnologymentioning

confidence: 98%

Pullulan for Advanced Sustainable Body- and Skin-Contact Applications

Coltelli

Danti

Clerck

et al. 2020

JFB

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The present review had the aim of describing the methodologies of synthesis and properties of biobased pullulan, a microbial polysaccharide investigated in the last decade because of its interesting potentialities in several applications. After describing the implications of pullulan in nano-technology, biodegradation, compatibility with body and skin, and sustainability, the current applications of pullulan are described, with the aim of assessing the potentialities of this biopolymer in the biomedical, personal care, and cosmetic sector, especially in applications in contact with skin.

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Pullulan-based Nanoparticles: Future Therapeutic Applications in Transmucosal Protein Delivery

Cited by 27 publications

References 17 publications

Overviews on the cellular uptake mechanism of polysaccharide colloidal nanoparticles

Overviews on the cellular uptake mechanism of polysaccharide colloidal nanoparticles

Solid-state Protein Formulations

Pullulan for Advanced Sustainable Body- and Skin-Contact Applications

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