Pullulan biosynthesis and its regulation in Aureobasidium spp.

Wei, Xin; Liu, Guanglei; Jia, Shu-Lei; Chi, Zhe; Huang, Zhong; Chi, Zhen‐Ming

doi:10.1016/j.carbpol.2020.117076

Cited by 49 publications

(27 citation statements)

References 45 publications

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“…The ATFDB exhibits the known transcription regulation and gene associations of several TFs, highlighting its ability to contribute to the formulation of novel biological hypotheses. It is capable of identifying a significant number of candidate transcriptional regulators in Aureobasidium spp., many of which have been verified and studied in experiments [ 2 , 3 , 7 , 13 , 14 , 38 , 39 , 40 , 41 ]. Due to the increasing number of genome sequencing studies, no other approach, including YEASTRACT+, the NCBI, or the TRANSFAC database, could be used to obtain the species-specific TFs of Aureobasidium spp.…”

Section: Resultsmentioning

confidence: 96%

“…Previously published research studies have established that the types of TFs in Aureobasidium spp. were much lower than those in Aspergillus spp., Saccharomyces cerevisiae , and other eukaryotes in the TRANSFAC ( ) (accessed on 20 January 2019) and the YEASTRACT+ ( ) databases [ 10 , 11 , 12 , 13 , 14 , 15 ]. However, due to the high genomic diversity of Aureobasidium spp., representative data in current databases are underrepresented.…”

Section: Introductionmentioning

confidence: 99%

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Transcription Factors in Aureobasidium spp.: Classification, Regulation and a Newly Built Database

Yang

Wang²,

Fang

et al. 2022

JoF

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Transcription factors (TFs) can regulate the synthesis of secondary metabolites through different metabolic pathways in Aureobasidium spp. In this study, a set of 16 superfamilies, 45 PFAM families of TFs with the DNA-binding domains, seven zinc finger families and eight categories of the C2H2 TFs have been identified in Aureobasidium spp. Among all the identified TFs, four superfamilies and six PFAM families are the fungal-specific types in this lineage. The Zn2Cys6 and fungal-specific domain regulators are found to be overwhelmingly predominated, while the C2H2 zinc finger class comprises a smaller regulator class. Since there are currently no databases that allow for easy exploration of the TFs in Aureobasidium spp., based on over 50 references and 2405 homologous TFs, the first TFs pipeline—the Aureobasidium Transcription Factor Database (ATFDB)—has been developed to accelerate the identification of metabolic regulation in various Aureobasidium species. It would be useful to investigate the mechanisms behind the wide adaptability and metabolite diversity of Aureobasidium spp..

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Section: Resultsmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Transcription Factors in Aureobasidium spp.: Classification, Regulation and a Newly Built Database

Yang

Wang²,

Fang

et al. 2022

JoF

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“…To date, there are four different species described in the literature to cause human infections: A. pullulans, A. proteae, A. mansoni and A. melanigenum, the last appearing to be more pathogenic [7,8]. A. pullulans is mostly known for the production of pullulan, an extracellular polysaccharide fundamental to resistance to desiccation, used in different biotechnological fields (production of adhesives/oxygenimpermeable films) [9]. A. pullulans has a low pathogenicity and can often colonise the skin, causing onychomycosis or keratitis after traumatic inoculation in healthy individuals, but it can also grow on implanted medical devices such as peritoneal dialysis catheters and central venous catheters [4,[10][11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

Atypical pulmonary phaeohyphomycosis due to Aureobasidium spp. – case report and brief literature review

et al. 2022

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We report on a case of probable invasive Auerobasidium spp. pulmonary infection in a patient with myelodysplastic syndrome. The patient was successfully treated with liposomal amphotericin B monotherapy, with transition to orally administered isavuconazole. This case shows an atypical initial radiological presentation with diffuse ground-glass opacities, as previously demonstrated in cases of Aureobasidium spp. hypersensitivity pneumonitis. Moreover this case further highlights the difficulties associated with the diagnosis and complexity in the management of Aureobasidium spp. infections.

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“…In the Dothioraceae family, only the Aureobasidium pullulans species is associated with CBM; human infection with this species is considered opportunistic and rare [29]. This fungus can not only be found in plant tissues but also in fresh and seawater from tropical and temperate regions of the world [29,89,90]. Initially, colonies assume a yellowish-brownish color and, over time, become grayishgreenish [89].…”

Section: Diversity Of Etiologic Agents Of Cbmmentioning

confidence: 99%

Reviewing the Etiologic Agents, Microbe-Host Relationship, Immune Response, Diagnosis, and Treatment in Chromoblastomycosis

Passero

Cavallone

Belda

2021

Journal of Immunology Research

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Chromoblastomycosis (CBM) is a neglected human disease, caused by different species of pigmented dematiaceous fungi that cause subcutaneous infections. This disease has been considered an occupational disease, occurring among people working in the field of agriculture, particularly in low-income countries. In 1914, the first case of CBM was described in Brazil, and although efforts have been made, few scientific and technological advances have been made in this area. In the field of fungi and host cell relationship, a very reduced number of antigens were characterized, but available data suggest that ectoantigens bind to the cell membrane of host cells and modulate the phagocytic, immunological, and microbicidal responses of immune cells. Furthermore, antigens cleave extracellular proteins in tissues, allowing fungi to spread. On the contrary, if phagocytic cells are able to present antigens in MHC molecules to T lymphocytes in the presence of costimulation and IL-12, a Th1 immune response will develop and a relative control of the disease will be observed. Despite knowledge of the resistance and susceptibility in CBM, up to now, no effective vaccines have been developed. In the field of chemotherapy, most patients are treated with conventional antifungal drugs, such as itraconazole and terbinafine, but these drugs exhibit limitations, considering that not all patients heal cutaneous lesions. Few advances in treatment have been made so far, but one of the most promising ones is based on the use of immunomodulators, such as imiquimod. Data about a standard treatment are missing in the medical literature; part of it is caused by the existence of a diversity of etiologic agents and clinical forms. The present review summarizes the advances made in the field of CBM related to the diversity of pathogenic species, fungi and host cell relationship, antigens, innate and acquired immunity, clinical forms of CBM, chemotherapy, and diagnosis.

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Pullulan biosynthesis and its regulation in Aureobasidium spp.

Cited by 49 publications

References 45 publications

Transcription Factors in Aureobasidium spp.: Classification, Regulation and a Newly Built Database

Transcription Factors in Aureobasidium spp.: Classification, Regulation and a Newly Built Database

Atypical pulmonary phaeohyphomycosis due to Aureobasidium spp. – case report and brief literature review

Reviewing the Etiologic Agents, Microbe-Host Relationship, Immune Response, Diagnosis, and Treatment in Chromoblastomycosis

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