Pulmonary Abnormalities in Young, Light-Use Waterpipe (Hookah) Smokers

Strulovici-Barel, Yael; Shaykhiev, Renat; Salit, Jacqueline; Deeb, Ruba S.; Krause, Anja; Kaner, Robert J.; Vincent, Thomas L.; Agosto-Perez, Francisco; Wang, Guoqing; Hollmann, Charleen; Shanmugam, Vignesh; AlMulla, Ahmad; Sattar, Hisham A.; Mahmoud, Mai; Mezey, Jason G.; Gross, Steven S.; Staudt, Michelle R.; Walters, Matthew S.; Crystal, Ronald G.

doi:10.1164/rccm.201512-2470oc

Cited by 26 publications

(32 citation statements)

References 47 publications

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“… 27 Strikingly, recent data suggest that young, light-use water pipe smokers have a lower diffusion capacity, abnormal epithelial lining, fluid metabolome profile, increased proportions of small airway epithelial secretory and intermediate cells, and reduced proportions of small airway epithelial ciliated cells as compared to non-smokers. 28 Furthermore, markedly abnormal small airway epithelial and alveolar macrophage transcriptomes as well as elevated levels of apoptotic endothelial cell microparticles were reported, highlighting that the major bronchial changes caused by water pipe exposure might differ from those associated with cigarette smoking. 28 …”

Section: Discussionmentioning

confidence: 99%

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Airway reactivity to mannitol is similarly increased in chronic cigarette and water pipe smokers

Scherr

Schmidlin

Albisser

et al. 2018

COPD

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BackgroundIn contrast to cigarette smoking, the association between water pipe smoking and airway hyperresponsiveness remains widely unexplored.MethodsA bronchoprovocation challenge with mannitol was performed in young adults recruited at the University of Basel, Switzerland. Subjects were categorized as acute water pipe smokers (single episode of water pipe smoking, no or <0.5 pack-years cigarette smoking); chronic water pipe smokers (weekly for ≥4 weeks, no or <0.5 pack-years cigarette smoking); cigarette smokers (no water pipe smokers); and never-smokers (no cigarette or water pipe smokers). Primary outcomes were airway reactivity as measured by the response-to-dose ratio (RDR) and airway responsiveness measured by the provocation dose to cause a 15% fall in forced expiratory volume in 1s (FEV1; PD15).ResultsSeventy-four subjects with a mean age of 22.5±2.5 years and FEV1 % predicted 90.1%±8.6% were included. Subgroups were matched in terms of age, gender, and spirometry results. RDR in chronic water pipe smokers and cigarette smokers was similar (0.013%/mg [0.010–0.015] vs 0.023%/mg [0.011–0.051], respectively; p=0.12) but significantly higher than in never-smokers (0.007%/mg [0.005–0.010], p<0.01). Neither a history of asthma (p=0.88) nor a positive skin prick test (p=0.69) was associated with increased airway reactivity to the mannitol challenge test. PD15 differed significantly between cigarette smokers and never-smokers (155 mg [115–395] vs 315 mg [155–475], respectively; p=0.04).ConclusionWeekly water pipe smoking may increase airway reactivity to a similar extent as cigarette smoking.

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Section: Discussionmentioning

confidence: 99%

“… 28 Furthermore, markedly abnormal small airway epithelial and alveolar macrophage transcriptomes as well as elevated levels of apoptotic endothelial cell microparticles were reported, highlighting that the major bronchial changes caused by water pipe exposure might differ from those associated with cigarette smoking. 28 …”

Section: Discussionmentioning

confidence: 99%

Airway reactivity to mannitol is similarly increased in chronic cigarette and water pipe smokers

Scherr

Schmidlin

Albisser

et al. 2018

COPD

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“…WTS is associated with many of the similar systemic conditions as cigarette smoking including cancer, respiratory and cardiovascular problems, and adverse pregnancy outcomes (Table ) …”

Section: Effect Of Waterpipe Tobacco Smoking On Oral and Systemic Heamentioning

confidence: 99%

Increasing popularity of waterpipe tobacco smoking and electronic cigarette use: Implications for oral healthcare

Ramôa

Eissenberg

Sahingur

2017

J of Periodontal Research

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Cigarette smoking increases the risk of developing several systemic conditions including cancer, cardiovascular and pulmonary diseases. Cigarette smoking is also detrimental to oral health as it increases the incidence and severity of oral cancer, periodontal diseases, and periimplantitis, as well as impacting negatively dental patients’ response to therapy. Therefore, consideration of smoking behavior and recommendation of smoking cessation are important parts of dental treatment planning. However, cigarettes are no longer the most popular form of tobacco use among adolescents in the United States and globally. In recent years, tobacco smoking using a waterpipe (“hookah”, “shisha”) and use of electronic cigarettes (ECIGs) has increased significantly. Thus, dental clinicians likely will treat more patients who are waterpipe and/or ECIG users. Yet, the literature on the health effects of waterpipe and ECIGs use is sparse. Both waterpipe and ECIGs deliver the dependence-producing drug nicotine. Waterpipe tobacco smoking has been associated with periodontitis, dry socket, premalignant lesions and oral and esophageal cancer. The health effects of long-term ECIG use are unknown. The purpose of this review is to inform healthcare professionals about waterpipe and ECIGs, highlight emerging evidence on the biological effects of these increasingly popular tobacco products, and introduce perspectives for dental patient management and future research.

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“…Recently, microRNA expression pro ling of E-cig exposed human airway epithelial cells has been reported (43). The waterpipe smokers have differential gene expression in small airway epithelial cells and alveolar macrophages in comparison to non-smokers (44). Further, waterpipe smokers small airway epithelial cells have epigenetic related changes in gene expression (45).…”

Section: Discussionmentioning

confidence: 99%

Exosomal microRNAs are novel circulating biomarkers in cigarette,waterpipe smokers, E-cigarette users and dual smokers

Singh

Maremanda

et al. 2020

Preprint

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Background: Electronic cigarettes (e-cigs) produce aerosolized substances by heating a liquid, which contains large number of chemicals. The aerosol generated by E-cig may produce adverse health effects. Cigarette smoke exposure causes various diseases including COPD, atherosclerosis, and lung cancer. Waterpipe tobacco smoking also causes various acute and chronic health effects including cardiopulmonary diseases. microRNAs are present in higher concentration in exosomes that play a major role in various physiological and pathological functions. We hypothesized that the non-coding RNAs transcript may serve as susceptibility to disease biomarkers by smoking and vaping. Results: Our data show the enrichment of various non-coding RNAs that include microRNAs, tRNAs, piRNAs, snoRNAs, snRNAs, Mt-tRNAs, and other biotypes in exosomes. A comprehensive differential expression analysis of microRNAs, tRNAs and piRNAs showed significant changes across different pairwise comparisons. The seven microRNAs that were common and differentially expressed of when all the smoking and vaping groups were compared with non-smokers (NS) are hsa-let-7a-5p, hsa-miR-21-5p, hsa-miR-29b-3p, hsa-let-7f-5p, hsa-miR-143-3p, hsa-miR-30a-5p and hsa-let-7i-5p. The e-cig vs. NS group has differentially expressed 5 microRNAs (hsa-miR-224-5p, hsa-miR-193b-3p, hsa-miR-30e-5p, hsa-miR-423-3p, hsa-miR-365a-3p, and hsa-miR-365b-3p) that is specific for this group and are not expressed in other three groups. Gene set enrichment analysis of microRNAs showed significant changes in the top six enriched functions that consisted of biological pathway, biological process, molecular function, cellular component, site of expression and transcription factor in all the groups. Further, the pairwise comparison of tRNAs and piRNA in all these groups revealed significant changes in their expressions. Conclusions: Plasma exosomes of cigarette smokers, waterpipe smokers, e-cig users and dual smokers have common differential expression of microRNAs which may serve to distinguish smoking and vaping subjects from NS. Among them has-let-7a-5p has high sensitivity and specificity to distinguish NS with the rest of the users, using ROC curve analysis. This study will pave the way for the utilizing the potential of exosomes/miRNAs as a novel theranostic agents in understanding the lung injury caused by tobacco smoking and vaping.

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Pulmonary Abnormalities in Young, Light-Use Waterpipe (Hookah) Smokers

Cited by 26 publications

References 47 publications

Airway reactivity to mannitol is similarly increased in chronic cigarette and water pipe smokers

Airway reactivity to mannitol is similarly increased in chronic cigarette and water pipe smokers

Increasing popularity of waterpipe tobacco smoking and electronic cigarette use: Implications for oral healthcare

Exosomal microRNAs are novel circulating biomarkers in cigarette,waterpipe smokers, E-cigarette users and dual smokers

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