Pulmonary adenocarcinoma: A renewed entity in 2011

Abstract

Lung cancer, of which non-small-cell lung cancer comprises the majority, is the leading cause of cancer-related deaths in the United States and worldwide. Lung adenocarcinomas are a major subtype of non-small-cell lung cancers, are increasing in incidence globally in both males and females and in smokers and non-smokers, and are the cause for almost 50% of deaths attributable to lung cancer. Lung adenocarcinoma is a tumour with complex biology that we have recently started to understand with the advent of various histological, transcriptomic, genomic and proteomic technologies. However, the histological and molecular pathogenesis of this malignancy is still largely unknown. This review will describe advances in the molecular pathology of lung adenocarcinoma with emphasis on genomics and DNA alterations of this disease. Moreover, the review will discuss recognized lung adenocarcinoma preneoplastic lesions and current concepts of the early pathogenesis and progression of the disease. We will also portray the field cancerization phenomenon and lineage-specific oncogene expression pattern in lung cancer and how both remerging concepts can be exploited to increase our understanding of lung adenocarcinoma pathogenesis for subsequent development of biomarkers for early detection of adenocarcinomas and possibly personalized prevention.

Epidemiological and Clinicopathological Characteristics of Lung Cancer in a Teaching Hospital in Iran

“…Feminine sexuality, histological type of adenocarcinoma (Rosai, 2009;Yang, 2011;Couraud et al, 2012;Matteis et al, 2013), and low age (Zhou and Christiani, 2011) comprise a higher proportion of non-smokers with lung cancer. Furthermore, the incidence of adenocarcinoma in non-smokers is higher in Asian population (Rosai, 2009) particularly in women (Kadara et al, 2012). The histological type of lung cancer which consists of 4 major classes (Petersen, 2011) is of prime importance in determining the type of therapy and prognosis.…”

Cigarette smoke induces the expression of Notch3, not Notch1, protein in lung adenocarcinoma

“…Lung cancer is a common cause of cancer-associated mortality in men and women worldwide (1,2). Lung adenocarcinoma (LAC), which is classified as a non-small cell lung cancer (NSCLC), is a prevalent subtype, accounting for ~25% of lung cancers (2,3).…”

“…Lung adenocarcinoma (LAC), which is classified as a non-small cell lung cancer (NSCLC), is a prevalent subtype, accounting for ~25% of lung cancers (2,3). Cigarette smoke remains to be a major etiological risk factor for lung cancer (1,4); a previous study reported that an increase in the incidence of LAC was correlated with cigarette smoking (5).…”

HIF-1α silencing suppresses growth of lung adenocarcinoma A549 cells through induction of apoptosis

“…Non-small cell lung cancer (NSCLC) accounts for 80% of all lung cancer diagnoses, with lung adenocarcinoma (AC) representing one of the most predominant histological types of NSCLC and accounting for 20-30% of all cases (1,2). The majority of patients with NSCLC are diagnosed in the late stage, when the tumor has become unresectable; therefore, chemotherapy remains the first treatment plan for advanced NSCLC.…”