Pulmonary adenocarcinoma with osteoblastic bone metastases in a cat

Abstract

A 12-year-old male cat with depression and dyspnoea was presented for investigation. Radiography and computed tomography revealed hydrothorax and solid masses involving the sternum, ribs and thoracic vertebrae. The cat died two days after first presentation, and postmortem examination revealed lung masses and proliferative bony lesions. Histologically, a neoplastic proliferation of epithelial cells was seen in the lungs, with a large amount of collagen and deposits of cholesterin. The bone lesions were also composed of neoplastic epithelial cells and abundant calcified osteoid, without atypia. A diagnosis of pulmonary adenocarcinoma with osteoblastic bone metastases was made. This is the first reported case of osteoblastic metastases in the cat.

Primary pulmonary adenocarcinoma in roe deer – a case report

“…Microscopic examination of samples from a cow showed bubble formation by neoplastic cells (16). In the case of a cat with lung adenocarcinoma, the microscopic image showed neoplastic lesions with a glandular structure and alveolar lesions with column cells (9). In contrast to our case, in ovine pulmonary adenomatosis the infiltrations of numerous macrophages were reported.…”

“…The localization of lung cancer in domesticated animals can vary. The tumour in the roe deer in our study was localized in the caudal lobe of the right lung, whereas in a case reported by Nakanishi et al, (9) the nodules and thickening of the pleura were found in the left lobe of the lung in a cat. The aforementioned study by Kim et al (4) describes multiple pulmonary tumours localized in both lungs in the case of a 10-year-old female Yorkshire terrier.…”

Metastatic pulmonary carcinomas in cats (‘feline lung–digit syndrome’): further variations on a theme

“…As a result, the generic illness script is less accessible to the clinician. Likewise, metastases to other sites such as the aortic trifurcation, 6 vertebrae, 11 skin (this report) and eye 2 do not immediately trigger an accessible generic illness script that focuses the clinician’s attention on the possibility of an underlying primary lung tumour. The disparate tissues in which metastases are observed may have in common a pattern of vascular perfusion with tortuosity or narrowing that favours small tumour emboli to lodge and give rise to nodular secondary tumours.…”

“…The disparate tissues in which metastases are observed may have in common a pattern of vascular perfusion with tortuosity or narrowing that favours small tumour emboli to lodge and give rise to nodular secondary tumours. 3,11 Many experienced feline physicians therefore recommend obtaining thoracic radiographs in all cats without obvious localisable signs, because of the propensity of cats to ‘hide’ signs of intrathoracic disease, whether it is located in the lungs, mediastinum or pleural space.…”

Feline lung–digit syndrome

“…5,[8][9][10] Clinical features in these cases are associated with the site of metastasis: cutaneous lesions are frequently found on the dorsum (and have been loosely termed feline 'lung-back syndrome'), 28,29 ocular lesions tend initially to present as ischaemic areas on the fundus and may lead to blindness, [30][31][32][33] and musculoskeletal and bone lesions commonly cause lameness and limb pain. [34][35][36] In all cases, a thorough clinical examination and thoracic radiography should suggest the primary aetiology, and this may be confirmed through histopathology.…”