Pulmonary alveolar microlithiasis

Muñoz, Jesús Giovanny Ballesteros; Rosas, Jorge Enrique Medina; Gualtero, Juan Manuel Bello; Patiño, John Darío Londoño; Vergara, Claudia Marsella Guzmán; Gutiérrez, César Augusto; Céspedes, José Ignacio Angarita; Valle-Oñate, Rafael

doi:10.1016/j.rcreue.2016.06.003

Cited by 3 publications

(4 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Open lung biopsy is not feasible in most cases; therefore, transbronchial biopsy to obtain lung parenchymal specimens remains the most widely accepted technique. [ 3 , 7 , 9 ] Four of our cases were confirmed by radiography, chest CT, bronchial mucosal biopsy through a flexible bronchoscope, and BAL fluid testing.…”

Section: Discussionmentioning

confidence: 64%

“…[ 2 ] In people with PAM, calcium phosphate deposits may also be seen in other tissues and organs in the body, such as the kidneys, gall bladder, testes, and heart valves (common in the aortic valve). [ 2 , 3 , 9 ] In some rare cases, the complications of aortic stenosis may be associated with the accumulation of these deposits, which impede blood flow. [ 3 ] All four of our patients had atypical clinical symptoms such as cough, chest pain, and dyspnea on exertion.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the differential diagnosis, on chest radiography, PAM can be mistaken for other lung diseases such as TB, pulmonary fungus, sarcoidosis, pneumoconiosis, and amyloidosis. [ 2 , 4 , 9 ] In all of the above diseases, diffuse pulmonary nodules may appear; however, in PAM, the lesions are usually larger and distributed in a completely different manner. In addition, PAM has milder clinical manifestations than these diseases.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Losing vigilance in diagnosing pulmonary alveolar microlithiasis: A report on four cases

Van Luong,

Anh,

Nguyen

2023

JCIS

View full text Add to dashboard Cite

Pulmonary alveolar microlithiasis (PAM) is a rare chronic lung disease characterized by calcium and phosphate deposition in the alveolar lumen throughout the parenchyma of both lungs, with predominance in the middle and lower lung fields. It is caused by mutations in the recessive gene, SLC34A2, on the autosomal chromosome. In this article, we characterize four cases of PAM and analyze the loss of diagnostic vigilance in two of them. Patients came to medical facilities with clinical manifestations such as cough, shortness of breath, chest pain, and fatigue. The initial diagnosis was unclear in two cases because the X-ray film’s quality was not good enough and the medical staff had little experience in clinical and chest X-ray interpretations for PAM. The definitive diagnosis was based on a combination of high-resolution computed tomography (CT) and bronchoalveolar lavage fluid testing. In addition, chest X-ray and high-resolution CT enable the assessment of the stage, progression, and severity of the disease. There is currently no specific treatment for PAM other than lung transplantation.

show abstract

Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Losing vigilance in diagnosing pulmonary alveolar microlithiasis: A report on four cases

Van Luong,

Anh,

Nguyen

2023

JCIS

View full text Add to dashboard Cite

show abstract

“…The second case from Colombia was a 44-year-old man who had RA for 15 years before presenting with epigastric pain, nausea, undocumented fever, and positive history of the first-degree relative with the diagnosis PAM. During his workup, the diagnosis of PAM was confirmed by chest X-ray and lung biopsy [ 10 ]. The third case was reported in Turkey and described a 17-year-old girl who presented with an 8-month history of pain and swelling in her knees, ankles, and hands.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Alveolar Microlithiasis and Rheumatoid Arthritis: A Case Report and Review of the Literature

Hafiz

Alahmed

Alahmadi

et al. 2021

Case Reports in Rheumatology

View full text Add to dashboard Cite

Pulmonary alveolar microlithiasis is a rare autosomal recessive condition that is characterized by the formation of excessive calcium phosphate microliths in the alveoli. Most patients are diagnosed in adulthood due to the slow progression of the disease. Children with this disease are asymptomatic, and changes in the lung parenchyma are usually discovered incidentally. The diagnosis is made by the combination of a positive chest imaging and histological examination. Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by chronic seropositive symmetrical inflammatory polyarthritis with numerous extra-articular manifestations. It targets the lining of the synovial membranes, frequently affects females more than males, and is treated with the disease-modifying antirheumatic drugs (DMARDs). If left untreated, it leads to increased morbidity, mortality, and socioeconomic burdens. In this case, we report a 19-year-old young man who presented with clinical and radiographic features of PAM associated with RA.

show abstract

Severe pulmonary hypertension in pulmonary alveolar microlithiasis: A comprehensive literature review

Cueto-Robledo,

Cantero-Ceballos,

Gonzalez-Hermosillo

et al. 2024

Current Problems in Cardiology

View full text Add to dashboard Cite

Pulmonary alveolar microlithiasis

Cited by 3 publications

References 52 publications

Losing vigilance in diagnosing pulmonary alveolar microlithiasis: A report on four cases

Losing vigilance in diagnosing pulmonary alveolar microlithiasis: A report on four cases

Pulmonary Alveolar Microlithiasis and Rheumatoid Arthritis: A Case Report and Review of the Literature

Severe pulmonary hypertension in pulmonary alveolar microlithiasis: A comprehensive literature review

Contact Info

Product

Resources

About