Pulmonary alveolar proteinosis: New insights from a single-center cohort of 70 patients

Abstract

This study shows that the use of BAL for the diagnosis of PAP can reduce the need of histological confirmation. A history of dust or fume inhalation is strongly associated with PAP, also with the autoimmune form. Smoking seems to influence the response to treatment, increasing the number of WLL necessary to reach remission.

Bilateral total lung lavage in a patient with pulmonary alveolar proteinosis

“…Orta ağır semptomları ve hipoksemisi olan hastalarda en yaygın ve etkili tedavi şekli total akciğer lavajıdır (13,14). Kesin histolojik tanı sonrasında Tablo 1'deki kriterlerden en az birini karşılayan olgulara bu tedavi önerilmektedir (15).…”

Pulmonary Alveolar Proteinosis and Tracheal Stenosis After Exposure to Fire and Fire Extinghuisher

“…Although pulmonary alveolar proteinosis is mainly idiopathic, patients with secondary PAP have also been identified. Secondary PAP factors include insecticides, inorganic dusts such as silica, hematological malignancies, HIV infection, leflunomide, toxic gas inhalation, exposure to silica, various industrial exposures to aluminum-and metal oxide-containing dusts and clinical conditions (6,7). Known as FM 200 or HFC-227 1,1,1,2,3,3,3-hepatofluoropropane is a hydrofluorocarbon used in the automatic fire extinguishing systems, and it is, in general, non-toxic under normal conditions (8).…”

Secondary Pulmonary Alveolar Proteinosis of Occupational Etiology: A Case Report

“…The primary disease is most commonly a hematologic malignancy [6,7] but PAP has been described in the context of immune system dysfunction (AIDS, bone marrow transplantation) or infection (Nocardia, Pneumocysta) [1,2]. Pulmonary alveolar proteinosis has also been connected with the inhalation of mineral dust such as silica, titanium oxide, aluminium oxide and insecticides [8][9][10][11][12]. Cadmium exposure has been found to cause tissue changes similar to pulmonary alveolar proteinosis in animals [13].…”