Pulmonary alveolar proteinosis with unusual complicating infections

Jones, Carroll C.

doi:10.1016/0002-9343(60)90103-0

Cited by 60 publications

(13 citation statements)

References 11 publications

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“…Two years after the first report of primary AP, several authors underlined the rare but significant association of AP with hematological malignancies [13,23]. The term "secondary AP" refers to cases of AP occurring in patients with a non-pulmonary underlying condition.…”

Section: Introductionmentioning

confidence: 99%

Secondary alveolar proteinosis in cancer patients

Ladeb

Fleury‐Feith²,

Escudier³

et al. 1996

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Pulmonary alveolar proteinosis (AP) is a rare cause of progressive respiratory failure in the normal host. It was first described by Rosen and coworkers in 1958 on the morphological basis of the accumulation of a PAS-positive material in the alveolar space. A couple of years later, AP was found to be unexpectedly associated with malignant diseases, especially with acute or chronic myeloid leukemias. These forms were called secondary AP in opposition to the primary forms observed in normal hosts. Probably because of its morphological definition and late diagnosis by means of histology or autopsy material, secondary AP has been considered to be life-threatening for a long time. However, recent observations show that AP can be diagnosed early in the course of the disease, especially through bronchoalveolar lavage, as long as the pathologist is aware of this possibility. Another point is that secondary AP can be reversible, both clinically and morphologically. This article summarizes the clinical features, morphological findings, and the main malignant diseases associated with secondary AP. We also comment on the hypotheses proposed in the literature to explain the association of AP, malignant disease, and immunosuppression. Alveolar macrophage is likely a key factor in the occurrence of secondary AP.

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Section: Introductionmentioning

confidence: 99%

Secondary alveolar proteinosis in cancer patients

Ladeb

Fleury‐Feith²,

Escudier³

et al. 1996

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“…In our patient PAP presented through recurrent episodes of acute pneumonitis [5]. The difficulties in diagnosis were due to the atypical picture of pulmonary infiltrates on the chest X-rays, and the clinical presenta tion that mimicked infection.…”

Section: Discussionmentioning

confidence: 72%

“…PAP has been described in asso ciation with several hematologic disorders such as sickle cell trait anemia [8], idiopath ic aplastic anemia [11], leukopenia [4], thrombocythemia [6], acute and chronic leukemias [3,5], lymphomas [3] and in pre leukemic states [2].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Alveolar Proteinosis Associated with Fanconi’s Anemia

Eldar¹,

Shoenfeld²,

Zaizov³

et al. 1979

Respiration

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“…If secondary PAP is diagnosed and the cause of the disease treated appropriately, there is usually a resolution of the PAP manifestation due to improved function of macrophages. 14,15 The investigation and treatment of congenital PAP is beyond the scope of this review.…”

Section: Rationale and Approach To Patient Evaluationmentioning

confidence: 99%