Pulmonary Amyloidosis in a Patient With Langerhans Cell Histiocytosis

Mukherjee, Anirban; Dhull, Varun Singh; Sharma, Punit; Parida, Girish Kumar; Jain, Sachin; Pal, Lily; Kumar, Rakesh

doi:10.1097/rlu.0b013e3182a7556d

Cited by 3 publications

(4 citation statements)

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“…We identified 19 articles [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ] describing pulmonary amyloidosis and PET/CT scan in Medline, EmBase and the ISI Web of Science. Data on the clinical presentation, histopathological and imaging findings of 41 patients (including our case) are summarized in table 1 (PET positive) and table 2 (PET negative).…”

Section: Results Of Different Publicationsmentioning

confidence: 99%

“…For pulmonary amyloidosis, there are three types of location: parenchymal nodules (nodular parenchymal form), diffuse interstitial deposits (diffuse alveolar septal form) or submucosal deposits in the airways (tracheobronchial form) [ 2 ]. Calcification is common [ 15 , 19 , 20 , 23 ], and a chest CT scan may show calcified deposits in over one third of patients with pulmonary amyloidosis [ 26 ]. In this study, the patient presented with multiple amyloid nodules with partial calcification in both lung fields on CT scan (fig.…”

Section: Discussionmentioning

confidence: 99%

“…18 F-FDG PET has a high sensitivity and specificity for the characterization of pulmonary nodules [ 5 ]. As with all diagnostic modalities, 18 F-FDG PET gives false-positive [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ] and false-negative [ 28 , 29 , 30 ] results. A number of metabolically active nonmalignant diseases, such as histoplasmosis, sarcoidosis, tuberculosis and aspergillosis, can result in increased 18 F-FDG accumulation [ 3 , 4 ].…”

Section: Discussionmentioning

confidence: 99%

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18F-FDG PET/CT in Patients with Nodular Pulmonary Amyloidosis: Case Report and Literature Review

et al. 2014

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A 62-year-old woman was found to have multiple bilateral pulmonary nodules showing different ¹⁸F-fluorodeoxyglucose (FDG) uptakes on positron-emission tomography/computed tomography (PET/CT). Only the largest nodule in the left lower lobe showed an increased ¹⁸F-FDG uptake on PET/CT. Three nodules were surgically resected from different lobes of the left lung. Two lobes were benign and showed amyloid deposition. The largest nodule in the left lower lobe showed adenocarcinoma and a heavy amyloid deposition. Pulmonary amyloidosis should be added to the differential diagnosis for cases with multiple pulmonary nodules that show different ¹⁸F-FDG uptakes on PET/CT. To the best of our knowledge, this is the second reported case of a lung nodule consisting of adenocarcinoma and amyloid deposition.

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Section: Results Of Different Publicationsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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18F-FDG PET/CT in Patients with Nodular Pulmonary Amyloidosis: Case Report and Literature Review

et al. 2014

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“…In the case of lung lesions, 18 F-FDG PET/CT is sometimes inferior to conventional diagnostic CT [12,13], especially in examining pulmonary vesicles. Small nodules and interstitial changes often appear negative on 18 F-FDG PET/ CT.…”

Section: Discussionmentioning

confidence: 99%

Application of ¹⁸F‐FDG PET/CT in Langerhans Cell Histiocytosis

Luo

Huang

et al. 2022

Contrast Media & Molecular Imaging

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Purpose. This study aims to explore the application value of the 18F-FDG PET/CT imaging in diagnosing, staging, and typing Langerhans cell histiocytosis (LCH) via the morphological and metabolic analyses of the 18F-FDG PET/CT images. Methods. We retrospectively analyzed the 18F-FDG PET/CT images and clinical data of nineteen patients with LCH. The shape, size, density, distribution, and 18F-FDG uptake of all lesions were documented. In addition, the SUVmax of the lesions, liver, and blood pool was measured prior to calculating the lesion-to-liver and lesion-to-blood pool ratios. Results. Among the 19 analyzed patients, the positive rate of the PET/CT image was 94.7% (18/19), with 1 false negative (5.3%, 1/19) case occurring in the cutaneous LCH. Among the 76 lesions, 69 were FDG-avid lesions (69/76, 90.8%). Additionally, we observed no FDG uptake in 7 lesions (7/76, 9.2%). In contrast, 59 lesions (59/76, 77.6%) were abnormal on diagnostic CT scan, but 17 lesions (17/76, 22.4%) were undetected. The 18F-FDG PET/CT image revealed additional 6 lesions in the bone, 4 in the lymph node, 3 in the spleen, and 3 occult lesions, which CT scan did not detect. Additionally, there were 6 cases with single-system LCH. The remaining 13 cases were multisystem LCH. Our 18F-FDG PET/CT image analyses altered the typing of 4 LCH patients. In the case of all lesions, the mean SUVmax of the 18F-FDG-avid lesions was 5.4 ± 5.1 (range, 0.8∼26.2), and the mean lesion-to-liver SUVmax ratio was 3.1 ± 2.52 (range, 0.7∼11.9), and the mean lesion-to-blood pool SUVmax ratio was 4.6 ± 3.4 (range 0.7∼17.5). Conclusion. The 18F-FDG PET/CT image plays an essential role in LCH diagnosis, primary staging, and typing. It can accurately evaluate the distribution, range, and metabolic information of LCH, providing a vital imaging basis for the clinical evaluation of disease conditions, selection of treatment schemes, and determining patient prognosis.

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Solitary Bone Langerhans Cell Histiocytosis Demonstrated on Multimodality Imaging in an Adult

et al. 2020

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Multimodality imaging was performed on a 53-year-old woman who was suspected with malignant bone tumor in her left femoral midshaft on radiograph. An MRI demonstrated the lesion showed hypointensity on T1-weighted and high intensity on T2-weighted fat-saturated images. It was more extensive on MRI than that on radiograph, especially in bone marrow and parosteal soft tissue. The lesion accumulated radiotracer on bone scan and 18F-FDG PET/CT. Finally, a Langerhans cell histiocytosis was confirmed after surgery. The case cautions us Langerhans cell histiocytosis should be in the differential diagnosis spectrum in an adult with unexplained unifocal bone lesion on 18F-FDG PET/CT.

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Pulmonary Amyloidosis in a Patient With Langerhans Cell Histiocytosis

Cited by 3 publications

References 9 publications

18F-FDG PET/CT in Patients with Nodular Pulmonary Amyloidosis: Case Report and Literature Review

18F-FDG PET/CT in Patients with Nodular Pulmonary Amyloidosis: Case Report and Literature Review

Application of ¹⁸F‐FDG PET/CT in Langerhans Cell Histiocytosis

Solitary Bone Langerhans Cell Histiocytosis Demonstrated on Multimodality Imaging in an Adult

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Pulmonary Amyloidosis in a Patient With Langerhans Cell Histiocytosis

Cited by 3 publications

References 9 publications

18F-FDG PET/CT in Patients with Nodular Pulmonary Amyloidosis: Case Report and Literature Review

18F-FDG PET/CT in Patients with Nodular Pulmonary Amyloidosis: Case Report and Literature Review

Application of 18F‐FDG PET/CT in Langerhans Cell Histiocytosis

Solitary Bone Langerhans Cell Histiocytosis Demonstrated on Multimodality Imaging in an Adult

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Application of ¹⁸F‐FDG PET/CT in Langerhans Cell Histiocytosis