Pulmonary and pleural metastasis of intracranial anaplastic meningioma in a 3-year-old boy: A case report

Abstract

Abstract. In adults, meningiomas occasionally display aggressive behavior and may occasionally metastasize. By contrast, pediatric meningiomas are rare, and there is limited information regarding their clinical characteristics, treatment and prognosis. We herein report the case of a 3-year-old boy with anaplastic meningioma with a history of local recurrence and late pulmonary metastasis. At diagnosis, a 70-mm mass lesion in was identified in the right frontal lobe, with intratumoral hemorrhage. The tumor was attached to the falx cerebri and was completely resected. The histological diagnosis was anaplastic meningioma, World Health Organization grade III. Two months after the surgery, the meningioma recurred at the same site. Although the patient received radiotherapy after a second operation, the tumor metastasized to the lung and pleura 8 months after the initial operation. The metastasis was resistant to treatment, even after gross total resection, and the effectiveness of further radiotherapy was limited. The patient succumbed to the disease 1 year and 4 months after the initial diagnosis. The findings of the present case and a review of the relevant literature suggest that recurrence and metastasis of meningiomas are difficult to predict. Therefore, such patients should be carefully monitored throughout the follow-up period.

Role of Macrophages in Brain Tumor Growth and Progression

“…The intracranial tumors that we have analyzed in our discussion have differences and similarities regarding their clinical behavior and their biology, also regarding the interrelationship with the immune response, and particularly with the associated macrophagic component. It is well known that gliomas, meningiomas, and medulloblastomas metastasize very rarely in extracranial organs [ 129 , 130 , 131 ], but medulloblastoma disseminates frequently via the cerebrospinal fluid. TAMs are considered an important factor in the process of metastasization, especially for their ability to induce epithelial-mesenchymal transition in cancer cells of epithelial tumors [ 132 , 133 , 134 ].…”

Metastasis of Malignant Intracranial Meningioma to the Lung: Report of a Case and Review of the Relevant Literature

“…We reviewed cases of intracranial meningioma with pulmonary metastasis from the literature. The characteristics of the patients, intracranial meningioma, and pulmonary metastases are summarized in Table 1 [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. This rare scenario is more frequently observed in the fifth-to-seventh decades of life, and tumors are usually located in the parasagittal region.…”

Radioterapi Pada Meningioma Anak

“…Kemungkinan terjadinya metastasis paling sering ke paru (61%), hati, kelenjar getah bening, tulang, pleura dan mediastinum. 29 Mekanisme metastasis diperkirakan dari cairan serebrospinal dan sinus venosus. Metastasis seluruhnya ditemukan di paru-paru, dengan angka kesintasannya adalah 8-30 bulan.…”