Pulmonary Artery Hypoplasia in Neonates With Tetralogy of Fallot

Petit, Christopher J.; Glatz, Andrew C.; Goldstone, Andrew B.; Law, Mark A.; Romano, Jennifer C.; Maskatia, Shiraz A.; Chai, Paul J.; Zampi, Jeffrey D.; Meadows, Jeffery J.; Nicholson, George T.; Shahanavaz, Shabana; Qureshi, Athar M.; McCracken, Courtney E.; Mascio, Christopher E.; Batlivala, Sarosh P.; Asztalos, Ivor B.; Healan, Steven J.; Smith, Justin D.; Pettus, Joelle A.; Beshish, Asaad; Raulston, James E.B.; Hock, Krissie M.; Pajk, Amy L.; Goldstein, Bryan H.

doi:10.1016/j.jacc.2023.05.051

Cited by 6 publications

(3 citation statements)

References 28 publications

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“… 9 , 10 In humans, the predominant source of pulmonary blood supply in severe forms of TOF is a patent ductus arteriosus or MAPCAs, and assessment of the origin and course of these and any other abnormal vessels is essential for clinical decision-making and preoperative planning. 8 , 9 , 11 The dog in this report was characterized as having type B pulmonary circulation, which includes native PA flow and MAPCAs compared with only native PAs (type A) or MAPCAs (type C). 12 The presence of MAPCAs is associated with PA hypoplasia or atresia.…”

Section: Discussionmentioning

confidence: 99%

Complex Tetralogy of Fallot in an Acyanotic Adult Dog

Malcolm,

Saunders

2024

CASE

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Section: Discussionmentioning

confidence: 99%

Complex Tetralogy of Fallot in an Acyanotic Adult Dog

Malcolm,

Saunders

2024

CASE

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“…This can be explained by decreased blood flow from the right ventricle into the pulmonary vascular system in fetuses with TOF. Vascular remodeling occurred in the middle membrane of the pulmonary trunk in fetuses with TOF due to decreased blood flow, resulting in thin and sparse elastic fibers and increased content of collagen fibers and matrix 7,8 . Moreover, suppression of nitric oxide (NO) and prostaglandin‐I‐2 (PGI 2 ) actions as a result of low pulmonary blood flow in fetuses with TOF leads to vasoconstriction, which is closely related to the maintenance of high vascular impedance in the fetal lung.…”

Section: Discussionmentioning

confidence: 99%

“…Vascular remodeling occurred in the middle membrane of the pulmonary trunk in fetuses with TOF due to decreased blood flow, resulting in thin and sparse elastic fibers and increased content of collagen fibers and matrix. 7,8 Moreover, suppression of nitric oxide (NO) and prostaglandin-I-2 (PGI 2 ) actions as a result of low pulmonary blood flow in fetuses with TOF leads to vasoconstriction, which is closely related to the maintenance of high vascular impedance in the fetal lung. The imbalance between PGI 2 and thromboxane A2 causes local platelet aggregation, which may stimulate the migration and division of endomyocytes, resulting in histological changes in the MPA.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Pulmonary Arterial Vascular Impedance in Fetuses With Tetralogy of Fallot

Liu,

Xu,

Zhou

et al. 2024

J of Ultrasound Medicine

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ObjectiveTo evaluate the vascular impedance of the pulmonary arteries in fetuses with tetralogy of Fallot (TOF) by Doppler echocardiography.MethodsA total of 42 fetuses with TOF (TOF group) and 84 gestational age‐matched normal fetuses (control group) were prospectively collected from the Second Xiangya Hospital of Central South University from August 2022 to January 2023. The severity of TOF was classified into mild TOF (z score ≥−2), moderate TOF (−4 < z score < −2), or severe TOF (z score ≤−4) according to the z score value of the pulmonary annulus diameter. The pulsatility index (PI) of the main pulmonary artery (MPA), distal left pulmonary artery (DLPA), and distal right pulmonary artery (DRPA) were measured by pulsed‐wave Doppler. The differences in clinical data and echocardiographic parameters between TOF group, control group, and TOF subgroups were compared.ResultsCompared with the control group, MPA‐PI increased significantly, whereas DLPA‐PI and DRPA‐PI decreased in TOF group (all P < .001). There were no significant differences in MPA‐PI and DRPA‐PI among mild TOF, moderate TOF, and severe TOF (all P > .05). However, DLPA‐PI decreased significantly in severe TOF compared with mild TOF (P < .05).ConclusionFetuses with TOF presented increased vascular impedance in the pulmonary trunk and decreased impedance in distal pulmonary artery branches. Further large and follow‐up studies are needed to demonstrate the associations between those changed vascular impedances and the development of PA in patients with TOF.

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Management of Infants With Tetralogy of Fallot

Love

2023

Journal of the American College of Cardiology

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Pulmonary Artery Hypoplasia in Neonates With Tetralogy of Fallot

Cited by 6 publications

References 28 publications

Complex Tetralogy of Fallot in an Acyanotic Adult Dog

Complex Tetralogy of Fallot in an Acyanotic Adult Dog

Assessment of Pulmonary Arterial Vascular Impedance in Fetuses With Tetralogy of Fallot

Management of Infants With Tetralogy of Fallot

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