Pulmonary Aspergilloma or Intracavitary Fungus Ball

Riley, Edgar Alsop

doi:10.7326/0003-4819-56-6-896

Cited by 27 publications

(2 citation statements)

References 14 publications

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“…Rarely invasive disease occurs. The characteristic x-ray appearance is that of a rounded mass surrounded by a crescent of air in a cavity (42). Other presentations include empty cavities, air-fluid levels or even no recognizabIe cavity.…”

Section: Auergic Reactionsmentioning

confidence: 99%

Aspergillosis

Bodey

Vartivarian

1989

Eur. J. Clin. Microbiol. Infect. Dis.

303

228

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Aspergillus spores are ubiquitous in the environment and may become concentrated in hospital ventilation systems. Colonization in normal hosts can lead to allergic diseases ranging from asthma to allergic bronchopulmonary aspergillosis. Normal hosts rarely develop invasive disease, which is primarily an infection of severely immunocompromised patients. The major predisposing factors for infection include prolonged neutropenia, chronic administration of adrenal corticosteroids, the insertion of prosthetic devices, and tissue damage due to prior infection or trauma. Since Aspergillus spp. are respiratory pathogens, the most common form of infection is pneumonia followed by sinusitis. Patients with preexistant cavitary disease may develop noninvasive aspergillomas. Most infections are caused by Aspergillus fumigatus. The organism is capable of invading across all natural barriers, including cartilage and bone. It has a propensity for invading blood vessels causing thrombosis and infarction. The diagnosis of pulmonary infection is usually difficult to establish because the organism is seldom cultured from sputum and can represent contamination in some cases. Therapy is immunocompromised hosts is less than satisfactory and amphotericin B is the only agent with significant activity. There is anecdotal evidence to suggest that the addition of 5-fluorocytosine to amphotericin B may be beneficial.

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Section: Auergic Reactionsmentioning

confidence: 99%

Aspergillosis

Bodey

Vartivarian

1989

Eur. J. Clin. Microbiol. Infect. Dis.

303

228

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“…The most common form of infection compiicating tuberculosis is the intracavity aspergilloma, where the infection is generally considered saprophytic (Hinson, Moon and Plummer, 1952;Villar, Pimentel and Costa, 1962;Riley and Tannenbaum, 1962). Locally invasive Aspergillus infections have also been described complicating tuberculosis, often following pneumonectomy (Barlow, 1954;Golebiowski, 1958;Kelmenson, 1959).…”

Section: Discussionmentioning

confidence: 99%

Miliary tuberculosis and disseminated aspergillosis

Solomon

Harris

1977

Postgraduate Medical Journal

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Multiple pulmonary aspergillomas in acute leukemia

Burke¹,

Coltman

1971

Cancer

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We present here a case of acute myelomonocytic leukemia treated with arabinosyl cytosine, long‐term broad spectrum antibiotics, and other supportive measures. The patient developed bilateral multiple pulmonary fungus balls almost simultaneously with a clinical and bone marrow remission of acute leukemia. The exact pathophysiology of these mycetomas is not clear, but the data are compatible with the hypotheses that the multiple mycetomas were preceded either by multiple pulmonary emboli with subsequent necrosis and infection or by multiple pulmonary hemorrhagic infarctions due to aspergillosis with subsequent aspergilloma formation. Neither alternative has been previously reported. The patient was treated with intravenous amphotericin B and aerosolized nystatin with resolution of the pulmonary lesions. Since the patient went into complete remission of the leukemia near the time of recognition of the aspergillosis, it is difficult to define the effect of the therapy on the pulmonary lesions.

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Pulmonary Aspergilloma or Intracavitary Fungus Ball

Cited by 27 publications

References 14 publications

Aspergillosis

Aspergillosis

Miliary tuberculosis and disseminated aspergillosis

Multiple pulmonary aspergillomas in acute leukemia

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