Pulmonary blastoma with diverse mesenchymal proliferation

Abstract

Pulmonary blastomas are extremely rare subpleural tumours consisting of relatively welldifferentiated branched tubular glands which resemble fetal lung tissue embedded in a malignant mesodermal stroma. The previous 13 established cases reported up to June 1969 are now supplemented by a fourteenth. The patient was a 32-year-old man who developed acute pain in the right chest followed by a haemorrhagic pleural effusion. At thoracotomy a yellowishwhite necrotic and vascular tumour was located lying loosely in the fissure between the upper and the middle lobes. The histological appearance of the tumour was unusual in that the mesodermal element was very variable and in different areas simulated fibrosarcoma, leiomyosarcoma, lipomyxosarcoma, and malignant haemangiopericytoma. This diversity of mesodermal proliferation is best explained on the basis that the tumour has originated in an embryonic or pleuripotential type of mesenchyme, the site of which is probably in the periphery of the lung.

Biphasic Tumors of the Lung

“…6,7 By the early 1970s, pulmonary blastoma had been reported only sporadically in the literature, with fewer than 20 cases mentioned. 8,9 All of the tumors occurred in adult patients and displayed the characteristic biphasic histologic features. Most of the cases had a fatal outcome, with variable range of survival.…”

Classic biphasic pulmonary blastoma: a case report and review of the literature

“…Pulmonary blastoma (PB) is an exceedingly rare type of lung cancer, comprising only 0.25% to 0.50% of all lung malignancies. 1 , 2 In the most recent World Health Organization classification, PB is included in the category of carcinomas with pleomorphic, sarcomatoid, or sarcomatous elements. 3 It can be divided into three separate histologic categories: one biphasic type (classic biphasic PB (CBPB)) and two monophasic types (well-differentiated fetal adenocarcinoma and pleuropulmonary blastoma).…”

Cure of Oligometastatic Classic Biphasic Pulmonary Blastoma Using Aggressive Tri-modality Treatment: Case Series and Review of the Literature

“…Pulmonary blastoma is an exceedingly rare type of lung cancer, comprising only 0.25% to 0.5% of all lung malignancies [1-2]. Barrett and Barnard first reported this tumor in 1945 and referred to the malignancy as “embryoma of the lung” due to its histologic resemblance to the first-trimester fetal lung [3-4].…”