Pulmonary carcinosarcoma: A case study and review of the literature

Cabarcos, Adrián; Dorronsoro, Marisa Gómez; Beristain, J.L. Lobo

doi:10.1016/0007-0971(85)90011-7

Cited by 54 publications

(22 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Tumors that protrude into the lumina of large tubular airways typically are associated with refractory recurring bacterial pneumonia in the subserved parenchymal tissue or with progressive dyspnea, cough, hemoptysis, and audible rhonchi over the affected lung field. 9 39 On the other hand, SC of the peripheral lung often causes no symptoms or initially manifests as chest pain that is caused by invasion of the pleura and thoracic soft tissues. 18 As intuitively expected, central endobronchial tumors are smaller than peripheral lesions; their average diameters are 6 cm and more than 10 cm, respectively.…”

Section: Clinical Attributesmentioning

confidence: 99%

Sarcomatoid Carcinomas of the Lung: A Clinicopathologic Review

Wick

Ritter

Humphrey

1997

American Journal of Clinical Pathology

104

View full text Add to dashboard Cite

Sarcomatoid carcinomas ( S O of the lung are the most common pulmonary neoplasms that exhibit a composition by spindled or pleomorphic tumor cells. As such, many of them may be confused easily with true sarcomas diagnostically unless special immunohistological or ultrastructural analyses are performed. Reactivity is expected for keratin, epithelial membrane antigen, or collagen type IV in the sarcomalike elements in SC, although it may be focal. Electron microscopy often shows the presence of junctional complexes between tumor cells, with or without pericellular basal lamina and cytoplasmic skeins of intermediate filaments. Current terminological preferences are such that several formerly used terms-including "spindle-cell carcinoma," "pulmonary blastoma," " s q u a m o u s cell carcinoma w i t h p s e u d o s a r c o m a t o u s stroma," "pseudosarcoma," and "carcinosarcoma" Therefore, a cytologically atypical spindle cell tumor of the lung is usually considered an SC unless rigorous immunohistologic and ultrastructural studies indicate otherwise. The goal of this review is to provide a discussion of neoplasms in this general category, using information taken from the pertinent literature and our personal experience. HISTORICAL AND TERMINOLOGICAL CONSIDERATIONSA historical controversy has existed about the mechanisms by which obvious foci of carcinoma of the lung are commingled with malignant but nondescript spindle cell elements or tissues with the apparent morphotype of a particular sarcoma pattern. Also, From the Lauren V.

show abstract

Section: Clinical Attributesmentioning

confidence: 99%

Sarcomatoid Carcinomas of the Lung: A Clinicopathologic Review

Wick

Ritter

Humphrey

1997

American Journal of Clinical Pathology

104

View full text Add to dashboard Cite

show abstract

“…The chance of making a preoperative diagnosis with bronchoscopic biopsy or TBFNAB depends on endobronchial localization of the tumor. It is reported that TBFNAB can provide a diagnosis in large lesions that are located peripherally (13). The bronchoscopic biopsy performed first in our case contained necrosis in most areas.…”

Section: Discussionmentioning

confidence: 53%

“…It is mostly seen The clinical signs are related to tumor localization (1). Cabarcos et al (13) have reported the most common clinical sign as a cough and chest pain in their series of 48 pulmonary adenocarcinoma patients while other findings were "wheezing" due to bronchial obstruction, dyspnea, obstructive pneumonia or atelectasis. The radiological findings are nonspecific and similar to other pulmonary carcinomas (7).…”

Section: Case Reportmentioning

confidence: 98%

Morphological and immunohistochemical features of malignant vascular tumors with special emphasis on glut1, and fkbp12 expressions

Kösemehmetoğlu

Gedikoğlu²,

Ruacan³

2011

TJPATH

View full text Add to dashboard Cite

Pulmonary carcinosarcoma, belonging to sarcomatoid carcinomas, is a quite rare tumor that contains both malignant epithelial and mesenchymal elements. This tumor has different phenotypic characteristics and clinical course compared to non-small cell lung tumors. A case diagnosed as carcinosarcoma is presented and its clinical and pathological features and the differential diagnosis are discussed. The case was a 74-year-old male admitted with shortness of breath and cough. The chest x-ray showed a left lung mass and a bronchoscopic examination was performed. Histopathological examination of the bronchoscopic biopsy showed necrosis and a malignant tumor consisting of diffuse infiltrative anaplastic cells. Surgery was performed and the case was diagnosed as carcinosarcoma in the resection material. Pulmonary carcinosarcoma is a rare lung tumor. Determination of tumoral cells and performing advanced investigations in resection material seem to be relatively easier than in small biopsies. However, this type of tumor can be encountered in small biopsy materials as in the presented case and should be kept in mind in relation to the differential diagnosis as small tissues can have only one, particularly mesenchymal, tumoral component.

show abstract

“…The cellular differentiation of each of the components is variable: the carcinomatous portion is predominantly epidermoid (70%), sometimes adenomatoid (20%) and very rarely un differentiated (10%) [1], The sarcoma is usually composed of poorly differentiated spindle cells and may contain foci of leiomyosarcoma, fibrosarcoma, chondrosarcoma, osteosarcoma or other foci of immature cells [41. Our case presented the most frequent type of association, epider moid carcinoma and sarcoma.…”

Section: Discussionmentioning

confidence: 99%

“…The rarity of primary pulmonary carcinosarcoma (rep resenting only 0.2-03% of all lung cancers, with no more than 100 cases reported [1,2]) has led to persistent contro versy regarding the clinical and radiological features not to mention diagnoses and treatment. We present a new case of gigantic dimensions (with a diameter of 20.5 cm, the largest described to date) in which the brief symptom atic period in spite of its size and the preoperative diagnostic difficulties, which justify the high incidence of surgical operations with incorrect diagnoses, were remarkable.…”

Section: Introductionmentioning

confidence: 99%

Gigant Carcinosarcoma

Ferrando¹,

Piédrola²,

Pérez-Rodriguez³

et al. 1992

Respiration

View full text Add to dashboard Cite

We present a case with gigantic carcinosarcoma (the largest described to date, diameter of 20.5 cm), located in the right upper lobe, in which the discordance between the brief clinical course with limited symptoms and its large size were remarkable. Preoperative diagnosis by bronchial biopsy, as used to be the case in this malignancy, was incorrect (epidermoid), and the define histological characterization was made by thoracotomy. The controversy about pathology, diagnosis and treatment of the carcinosarcoma is discussed.

show abstract

Pulmonary carcinosarcoma: A case study and review of the literature

Cited by 54 publications

References 17 publications

Sarcomatoid Carcinomas of the Lung: A Clinicopathologic Review

Sarcomatoid Carcinomas of the Lung: A Clinicopathologic Review

Morphological and immunohistochemical features of malignant vascular tumors with special emphasis on glut1, and fkbp12 expressions

Gigant Carcinosarcoma

Contact Info

Product

Resources

About