Pulmonary consequences of hypothyroidism

Sadek, Samiaa Hamdy; Khalifa, Walaa A.; Azoz, Ahmad Metwally

doi:10.4103/atm.atm_364_16

Cited by 32 publications

(20 citation statements)

References 21 publications

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“…In addition to impairing normal metabolic processes, hypothyroidism is a multifaceted condition associated with increasing digestive system, pulmonary, and hematologic complications. [8][9][10][11][12] Hypothyroidism has a significant impact on the digestive system, affecting function in the esophagus down to the colon. The findings in our study are consistent with that of Ling et al who found that 2.8% of patients with hypothyroidism experienced gastrointestinal complications within the first 30 days following THA.…”

Section: Discussionmentioning

confidence: 99%

Hypothyroidism Increases 90-Day Complications and Cost Following Primary Total Hip Arthroplasty

et al. 2019

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Hypothyroidism is common, and the incidence has been increasing annually in the United States. Abnormalities in thyroid hormone can have several effects on the endocrine, immune, and musculoskeletal systems of the body. The influence of hypothyroidism on outcomes following primary total hip arthroplasty (THA) is not well reported. The authors hypothesized that hypothyroidism was associated with a higher risk of postoperative complications and 90-day costs following primary THA. A retrospective review from 2005 to 2014 was performed using the Medicare Standard Analytical Files from the Pearl Diver database. Utilizing International Classification of Disease 9th revision (ICD-9) codes, the authors identified patients who underwent THA. Patients with a concurrent diagnosis of hypothyroidism were matched by age, gender, and Charlson's comorbidity index (CCI) to a control group. Ninety-day postoperative complications, readmission rates, complications related to implants, and cost of care were compared and assessed following primary THA between matched cohorts. Statistical analysis was performed using the programming language R (University of Auckland) to calculate odds ratios (OR) along with their respective 95% confidence intervals (95% CI), and p-values. A total of 383,898 patients underwent primary THA. Among them, 191,949 patients were diagnosed with hypothyroidism and 191,949 patients without hypothyroidism. Hypothyroidism was associated with greater odds of postoperative complications (p < 0.001), 90-day readmission rates (p < 0.001), implant related complications (p < 0.001), and total global 90-day episode of care cost (U.S. $17,549.96 vs. $16,645.01; p < 0.001). This study demonstrated an increased risk of postoperative complications (medical or implant related), increased readmission rates, and higher costs among patients with hypothyroidism following primary THA. Surgeons should counsel patients and determine strategies to medically optimize patients to mitigate risk and decrease cost.

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Section: Discussionmentioning

confidence: 99%

Hypothyroidism Increases 90-Day Complications and Cost Following Primary Total Hip Arthroplasty

et al. 2019

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“…Albeit both hypothyroidism 82 , and hyperthyroidism 83 may be associated with exertional dyspnoea, and fatigue can be the presenting complaint, their relationship with COPD has not been investigated.…”

Section: Endocrine Diseasesmentioning

confidence: 99%

Chronic Respiratory Abnormalities in the Multi-Morbid Frail Elderly

Beghè¹,

Clini²,

Fabbri³

2017

BRN

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Two-thirds of people aged ≥65 years have multi-morbidity. Multi-morbidity includes both physical and mental health conditions, as anxiety and depression, that almost invariably affect patients with multiple symptomatic chronic diseases. Management of a patient with any of the chronic diseases that are part of multi-morbidity is not just the management of that single index disease, but must include the active search and proper treatment of concomitant chronic diseases. The presence of concomitant chronic diseases should not alter the management of the index disease (e.g., chronic obstructive pulmonary disease [COPD]), and concomitant chronic diseases should be treated according to single diseases guidelines regardless of the presence of the index disease, obviously with careful consideration that this choice implies complex management, polypharmacy and potential adverse effects. Preliminary management programs suggest that a holistic integrated approach might improve quality of life and reduce hospital admissions and death in these multimorbid patients. (BRN Rev. 2017;3:247-66)

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“…I have read with interest the case–control study by Sadek et al on the pulmonary consequences of hypothyroidism in a cohort of Egyptian patients. [ 1 ] In the methodology, the authors employed spirometry to measure various components of pulmonary function tests (PFTs), namely, forced vital capacity (FVC), FVC%, forced expiratory volume in 1 s (FEV1s), FEV1s%, FEV1s/FVC, and forced expiratory flow (FEF 25–75 )%. [ 1 ] The authors found that FVC% and FEF 25–75 % were significantly reduced in the hypothyroid group ( P = 0.014, P = 0.000, respectively)compared to the control group.…”

mentioning

confidence: 99%

“…[ 1 ] In the methodology, the authors employed spirometry to measure various components of pulmonary function tests (PFTs), namely, forced vital capacity (FVC), FVC%, forced expiratory volume in 1 s (FEV1s), FEV1s%, FEV1s/FVC, and forced expiratory flow (FEF 25–75 )%. [ 1 ] The authors found that FVC% and FEF 25–75 % were significantly reduced in the hypothyroid group ( P = 0.014, P = 0.000, respectively)compared to the control group. [ 1 ] I presume that these findings ought to be cautiously interpreted.…”

mentioning

confidence: 99%