Pulmonary Cystic Disease Associated With COVID 19 Pneumonia: An Emerging Atypical Manifestation

Muñoz-Palacio, Bernardo J; Syro, Daniel; Pinzón, Miguel A.; Ramírez, Beatriz U.; Betancur, Juan Felipe

doi:10.7759/cureus.19352

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…Time will tell the role of heredity in cyst development [36]. Understanding the possibility that multiple etiologies may account for cyst development can help us develop the best treatment strategies [37,38].…”

Section: Discussionmentioning

confidence: 99%

Radiographic analysis provides evidence for the etiology of pulmonary cysts in COVID-19

Igbinoba,

Capaccione,

Dsouza

et al. 2023

Imaging

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Background and aimImaging of patients with COVID-19 has provided unique insights into the pathophysiology of the infection. Cysts are a rare manifestation of the disease in the lung. The aim of this research was to compare COVID-19-positive patients with cysts on CT to patients without cysts and propose a mechanism for cyst formation in this patient population based on radiographic observations.Materials and MethodsOur HIPAA-compliant IRB-approved research project involved a retrospective review of 219 chest CT scans identified in COVID-19-positive inpatients and emergency room patients at Columbia University Irving Medical Center from February 27, 2020 to July 17, 2020. A thoracic radiologist with over 20 years of experience reviewed the images on lung window settings and identified the presence of cysts, their distribution (central or pleural based), and if there was an accompanying pneumothorax. The extent of consolidation of the entire lung on a scale of 0–16 and the presence of fibrosis were also documented.ResultsCysts were identified in 10 of the 219 patients. CT scans with cysts were obtained on average on day 57 of symptoms (range 16–115 days) compared to CT scans of those without cysts that were obtained on average on day 19 (range 0–89 days). The distribution of cysts was heterogeneous; six patients had multiple cysts while four were isolated. Seven cysts were peripheral in distribution while three were central. Two patients with cysts developed a subsequent pneumothorax. Fifty percent of those with cysts had been intubated.ConclusionsPatients with COVID-19 develop cystic lung lesions for at least two reasons; pleural-based lesions are more likely areas of infarction and central lesions with surrounding ground glass are more likely related to infection and/or mechanical ventilation.

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Section: Discussionmentioning

confidence: 99%

Radiographic analysis provides evidence for the etiology of pulmonary cysts in COVID-19

Igbinoba,

Capaccione,

Dsouza

et al. 2023

Imaging

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“…Clinicians must recognize early typical and atypical presentations and complications in order to establish their associated factors, appropriate management strategies, prognoses, and the probability of long-term recovery. 3…”

Section: Introductionmentioning

confidence: 99%

Neonatal COVID-19 with Atypical Lung Cystic Lesions Mimicking Congenital Pulmonary Airway Malformation – A Diagnostic Dilemma

Ghazwani¹

2023

IMCRJ

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The COVID-19 epidemic is a major public health emergency that has affected every part of society worldwide, including neonates with different clinical presentations. It is essential to differentiate between increased incidence of complications related to this infection rather than an underlying congenital etiology. We report a rare case with atypical lung cystic lesions, diagnosed initially as congenital pulmonary airway malformation (CPAM) with management controversy but which turned out to be a COVID-19 viral pneumonia complication. Clinical tolerance and proper uses of radiological modalities are crucial to achieving better outcomes for patients. The literature is still missing reports on this topic and needs more studies to provide conclusive, evidence-based practice of this emerging neonatal viral infection. Vigilance in neonates with COVID-19 infection is highly recommended.

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“…CT scans can predict disease progression and detect its consequences (1,2). Bullous and cystic diseases of the lung in COVID-19 patients have been declared in some case reports (3). No large-scale study has examined the clinical characteristics of COVID-19 patients with pulmonary bullae and cystic diseases or their impact on survival.…”

Section: Introductionmentioning

confidence: 99%

COVID-19 and Pulmonary Bullae: Evidence from a Bicentric-Center, Cross-Sectional Study

Rafieian,

Ershadi,

Fattahi

et al. 2023

Arch Clin Infect Dis

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Background: More than 87% of patients with COVID-19 have at least one resistant symptom after recovery, and bullous disease may be as a one of these resistant conditions. Methods: This bicentric cross-sectional study examined hospitalised patients with confirmed COVID-19 and pulmonary bullous disease from July 2021 to February 2022 in two hospitals. A radiologist reviewed all patients' chest CT scans for the presence of bullae or cysts. Results: In this study, 34 COVID-19 patients with lung bullae were identified. The majority of bullae were small or medium-sized and located in the left or right lung, with 20.6% being bilateral. Most patients had a single bulla. The mortality rate was 29.4%, with an average survival time of 13 days for deceased patients. Increased age, smoking, respiratory comorbidities, intubation, and bilateral bullae were associated with lower survival time. However, no significant association was found between survival time and sex, size, or number of bullae. Findings provide important insights into the clinical implications of COVID-19 and lung bullae. Conclusions: Recognizing the coexistence of COVID-19 and pulmonary bullous disease is crucial as bilateral bullae were associated with lower survival time. Further research is needed to determine the relationship between COVID-19 and lung bullae.

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Pulmonary Cystic Disease Associated With COVID 19 Pneumonia: An Emerging Atypical Manifestation

Cited by 3 publications

References 20 publications

Radiographic analysis provides evidence for the etiology of pulmonary cysts in COVID-19

Radiographic analysis provides evidence for the etiology of pulmonary cysts in COVID-19

Neonatal COVID-19 with Atypical Lung Cystic Lesions Mimicking Congenital Pulmonary Airway Malformation – A Diagnostic Dilemma

COVID-19 and Pulmonary Bullae: Evidence from a Bicentric-Center, Cross-Sectional Study

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