Pulmonary delivery of synergistic combination of fluoroquinolone antibiotic complemented with proteolytic enzyme: A novel antimicrobial and antibiofilm strategy

Gupta, Purnima; Nirwane, Abhijit; Belubbi, Tejashree; Nagarsenker, Mangal S.

doi:10.1016/j.nano.2017.06.011

Cited by 40 publications

(19 citation statements)

References 41 publications

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“…Liposomes also considered a probable carrier for the intracellular distribution of antibacterial drugs attributable to their phospholipid bilayer structure. Thus, for example, the activity of anti-biofilm and antibacterial agents can be augmented by levofloxacin liposomes (Gupta et al, 2017) and ceftazidime liposomes (Zhou et al, 2012). As similar, chloramphenicol-loaded deoxycholic acid liposomes have antimicrobial action against MRSA (Hsu et al, 2017), and vancomycin-loaded liposomes increase and enhance the intracellular killing of MRSA (Pumerantz et al, 2011).…”

Section: Liposomesmentioning

confidence: 99%

Nanoparticles for treatment of bovine Staphylococcus aureus mastitis

2020

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Staphylococcus aureus (S. aureus) is one of the most important zoonotic bacterial pathogens, infecting human beings and a wide range of animals, in particular, dairy cattle. Globally. S. aureus causing bovine mastitis is one of the biggest problems and an economic burden facing the dairy industry with a strong negative impact on animal welfare, productivity, and food safety. Furthermore, its smart pathogenesis, including facultative intracellular parasitism, increasingly serious antimicrobial resistance, and biofilm formation, make it challenging to be treated by conventional therapy. Therefore, the development of nanoparticles, especially liposomes, polymeric nanoparticles, solid lipid nanoparticles, nanogels, and inorganic nanoparticles, are gaining traction and excellent tools for overcoming the therapeutic difficulty accompanied by S. aureus mastitis. Therefore, in this review, the current progress and challenges of nanoparticles in enhancing the S. aureus mastitis therapy are focused stepwise. Firstly, the S. aureus treatment difficulties by the antimicrobial drugs are analyzed. Secondly, the advantages of nanoparticles in the treatment of S. aureus mastitis, including improving the penetration and accumulation of their payload drugs intracellular, decreasing the antimicrobial resistance, and preventing the biofilm formation, are also summarized. Thirdly, the progression of different types from the nanoparticles for controlling the S. aureus mastitis are provided. Finally, the difficulties that need to be solved, and future prospects of nanoparticles for S. aureus mastitis treatment are highlighted. This review will provide the readers with enough information about the challenges of the nanosystem to help them to design and fabricate more efficient nanoformulations against S. aureus infections. ARTICLE HISTORY ). So, these new nanocarriers provide a new strategy to combat S. aureus mastitis problems. In order to provide an overview of the emerging nanocarriers in the bovine mastitis management and help the researcher to understand how they can discover a new trend to combat S. aureus mastitis by shifting their attention toward the world of nanocarriers. We searched PubMed, Scopus, and Web of Science for all the studies published over the last 20 years using the keywords "S. aureus mastitis" or "virulence factors of S. aureus" and "antimicrobial resistance" or "nanoparticles and nanogel". About 3000 records and 550 of closely related papers were screened for suitable studies. We summarized the features and treatment difficulty of S. aureus mastitis, the advantages, and prospects of nanoparticles and nanogels according to the related publications.

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Section: Liposomesmentioning

confidence: 99%

Nanoparticles for treatment of bovine Staphylococcus aureus mastitis

2020

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“…The bactericidal efficacy of levofloxacin was dramatically improved after the EPS was dismembered. Nagarsenker et al demonstrated that the liposomes loaded with serratiopeptidase could distinctly disrupt the EPS of S. aureus biofilm and enhance the bactericidal efficacy of levofloxacin 94 . Moreover, they also observed great probability to employ the dry powder of serratiopeptidase and levofloxacin liposomes to treat the biofilm infection in lungs by inhalational therapy.…”

Section: Therapeutic Methods Of Bacterial Infections With Serious Antmentioning

confidence: 99%

Emerging nanobiomaterials against bacterial infections in postantibiotic era

Zou

Gao

et al. 2020

VIEW

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Although numerous antibiotics have been developed and applied in clinic, bacterial infections are still serious threats to human health, due to the rapidly growing antibiotic resistance all over the world. The causes of antibiotic resistance include two main aspects: the formation of bacterial biofilms and the self‐evolution of bacteria under the antibiotic selection pressure. It is of great significance to develop effective strategies to treat the bacterial infections with serious antibiotic resistance. With excellent performance, such as size effect, specific physicochemical property, easy modification, and so on, nanomaterials exhibit enormous potential as enhancers or therapeutic agents to treat severe drug‐resistant bacterial infections. In this review, the underlying causes for the antibiotic resistance are fully summarized and discussed. Subsequently, the promising therapeutic methods by using nanomaterials are provided and discussed to treat bacterial infections with serious antibiotic resistance.

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“…Gupta et al demonstrated that levofloxacin liposomes exhibited prolonged, improved antibiofilm and antimicrobial efficacy in treating S. aureus infection. 76 Recently, it was confirmed that chloramphenicolloaded deoxycholic acid liposomes can increase antibacterial effect on keratinocyte-infected MRSA and that the deformable liposomes hold excellent biocompatibility. 77 It was reported that the compound of vancomycin-loaded liposome surface bounded with chitosan-modified gold nanoparticles has the ability of responding to bacterial toxins.…”

Section: Enhanced Intracellular Deliverymentioning

confidence: 97%

A review on nanosystems as an effective approach against infections of <em>Staphylococcus aureus</em>

Zhou¹,

Li²,

Chen³

et al. 2018

IJN

118

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Staphylococcus aureus (S. aureus) is an important zoonotic bacteria and hazardous for the health of human beings and livestock globally. The characteristics like biofilm forming, facultative intracellular survival, and growing resistance of S. aureus pose a great challenge to its use in therapy. Nanoparticles are considered as a promising way to overcome the infections’ therapeutic problems caused by S. aureus. In this paper, the present progress and challenges of nanoparticles in the treatment of S. aureus infection are focused on stepwise. First, the survival and infection mechanism of S. aureus are analyzed. Second, the treatment challenges posed by S. aureus are provided, which is followed by the third step including the advantages of nanoparticles in improving the penetration and accumulation ability of their payload antibiotics into cell, inhibiting S. aureus biofilm formation, and enhancing the antibacterial activity against resistant isolates. Finally, the challenges and future perspective of nanoparticles for S. aureus infection therapy are introduced. This review will help the readers to realize that the nanosystems can effectively fight against the S. aureus infection by inhibiting biofilm formation, enhancing intracellular delivery, and improving activity against methicillin-resistant S. aureus and small colony variant phenotypes as well as aim to help researchers looking for more efficient nano-systems to combat the S. aureus infections.

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Pulmonary delivery of synergistic combination of fluoroquinolone antibiotic complemented with proteolytic enzyme: A novel antimicrobial and antibiofilm strategy

Cited by 40 publications

References 41 publications

Nanoparticles for treatment of bovine Staphylococcus aureus mastitis

Nanoparticles for treatment of bovine Staphylococcus aureus mastitis

Emerging nanobiomaterials against bacterial infections in postantibiotic era

A review on nanosystems as an effective approach against infections of <em>Staphylococcus aureus</em>

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