Pulmonary deposition of a budesonide/γ-cyclodextrin complex in vitro

Crystal Structure Changes of γ-cyclodextrin After the SEDS Process in Supercritical Carbon Dioxide Affect the Dissolution Rate of Complexed Budesonide

“…1a,b, Table (5), indicated in Fig. 1a and b b Preparation described in (26) c Size order, largest diameter indicated with #1 d A minor tetragonal phase was also detected in the sample V). Thus, the possible removal of water and/or ethanol molecules from the interstitial positions of the tetragonal unit cells (Fig.…”

“…In the present study, budesonide/g-CD complexes were prepared with the precipitation, conventional SEDS and modified SEDS methods as described earlier (15,26). The XRPD pattern of the precipitated budesonide/g-CD complex powder (Fig.…”

The use of absorption enhancers to enhance the dispersibility of spray‐dried powders for pulmonary gene therapy

“…Moreover, Kobayashi and co-workers not only showed that the absorption of proteins can be greatly improved by pulmonary absorption enhancers, but suggested that such enhancers are more effective in dry powder formulations than in liquid dosage forms [32]. Although several studies demonstrate the pulmonary absorption enhancement effect on the delivery of pharmaceutically active agents, few articles report the influence of cyclodextrin derivatives on the dispersibility of drug particles for lung deposition [33,34]. The effect of these materials on the physical properties and functional deposition of spray-dried powders has yet to be investigated.…”

Chitosan and β-cyclodextrin microspheres as pulmonary sustained delivery systems

“…Furthermore, CHS has been used as a drug carrier to attain the desirable drug release profile and enhance the dissolution rate of low water soluble drugs [9][10][11] . In this paper, CHS is applied to prepare sustained release pulmonary delivery micropheres incorporating with β-cyclodextrin (β-CD) which is used as an excipient to improve pharmaceutical and biopharmaceutical properties of drugs [12] .…”