Pulmonary Diffusing Capacity and Volumes in Healthy Adults Measured with the Single Breath Technique

Viljanen, A. A.; Viljanen, B. C.; Halttunen, P; Kreus, K. -E.

doi:10.3109/00365518209168378

Cited by 7 publications

(4 citation statements)

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“…The histamine challenge testing had been performed according to the method described by Sovijarvi et al 1993, with hyperresponsiveness being graded as strong, (PD 15 <0.10 mg), moderate (PD 15 0.11-0.40 mg), or mild (PD 15 0.41-1.6 mg). The single breath diVusion capacity for carbon monoxide and speciWc diVusion capacity had been measured by a Masterlab Transfer or a Compact Lab Transfer device using Finnish reference values (Viljanen et al 1982).…”

Section: Lung Function Measurementsmentioning

confidence: 99%

New-onset adult asthma in relation to damp and moldy workplaces

Karvala

Toskala

Luukkonen

et al. 2010

Int Arch Occup Environ Health

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Section: Lung Function Measurementsmentioning

confidence: 99%

New-onset adult asthma in relation to damp and moldy workplaces

Karvala

Toskala

Luukkonen

et al. 2010

Int Arch Occup Environ Health

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“…Diffusing capacity (DLCO) was measured with a single‐breath method (Jaeger Masterscreen‐PFT, Sentry Suite software version 3.1, Vyaire Medical, Würzburg, Germany), using the gender‐specific Viljanen references 23,24 . DLCO represents the lung capacity to transfer gas from inspired air to the bloodstream 24 .…”

Section: Methodsmentioning

confidence: 99%

“…Diffusing capacity (DLCO) was measured with a single-breath method (Jaeger Masterscreen-PFT, Sentry Suite software version 3.1, Vyaire Medical, Würzburg, Germany), using the gender-specific Viljanen references. 23,24 DLCO represents the lung capacity to transfer gas from inspired air to the bloodstream. 24 As the study variable, we recorded the hemoglobin-corrected diffusing capacity for carbon monoxide (DLCOc), utilizing the DLCOc percentage of the predicted value (DLCOc%).…”

Section: Diffusing Capacitymentioning

confidence: 99%

Complete blood count, coagulation biomarkers, and lung function 6 months after critical COVID‐19

Kattainen,

Pitkänen,

Reijula

et al. 2024

Acta Anaesthesiol Scand

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BackgroundUnderstanding the recovery of post‐COVID‐19 organ dysfunction is essential.We evaluated coagulation 6 months post‐COVID‐19, examining its recovery and association with lung function.MethodsPatients treated for COVID‐19 at intensive care units between 3/2020 and 1/2021 were analyzed for complete blood count (CBC) and coagulation biomarkers (prothrombin time activity (%) (PT%), activated partial thromboplastin time (APTT), fibrinogen, coagulation factor VIII (FVIII), antithrombin (AT), and D‐dimer) during the 6 months post‐hospitalization. Results were compared with acute phase values and correlated with pulmonary function tests (PFT), including forced vital capacity (FVC) and hemoglobin‐corrected diffusing capacity percentage of predicted (DLCOc%), recorded 6 months post‐hospitalization. We examined the association between coagulation biomarkers and DLCOc% using linear regression with age, sex, and invasive mechanical ventilation (IMV) duration, and FVIII (correlated with DLCOc%) as covariates.ResultsMost CBCs and coagulation biomarkers had median values within the normal range. However, only 21% (15/70) of patients achieved full normalization of all biomarkers. Compared to acute COVID‐19, hemoglobin, PT%, and AT increased, while leukocytes, fibrinogen, FVIII, and D‐dimer decreased. Despite decreased levels, FVIII remained elevated in 46% (31/68), leukocytes in 26% (18/70), and D‐dimer in 27% (18/67) at 6 months. A weak negative correlation (r = −0.37, p = .036) was found between DLCOc% and FVIII. Multivariable analysis revealed a weak, independent association between DLCOc% and FVIII. Excluding patients with anticoagulation therapy, FVIII no longer correlated with DLCOc%, while AT showed a moderate correlation with DLCOc%.ConclusionOnly a few patients had normal CBC and coagulation biomarker values 6 months after critical COVID‐19. A weak negative correlation between DLCOc% and FVIII suggests that deranged coagulation activity may be associated with reduced diffusing capacity.

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“…The scanned and decoded medical records include the original notes of the physicians and copies of various diagnostic tests such as results of spirometry, diffusion capacity, and ECG traces. The reference values for FEV 1 , FVC, PEF, and DLCOcVA used in Finnish clinical practice are validated in large Finnish population samples consisted of both genders and a wide range of age groups (15). The study approach was approved by the Coordinating Ethics Committee of the Helsinki and Uusimaa Hospital District and the permission to conduct this research was granted by the Helsinki and Turku University Hospitals.…”

Section: Data Processingmentioning

confidence: 99%

Real-World Clinical Data Identifies Gender-related Profiles in Chronic Obstructive Pulmonary Disease

Laitinen

Hodgson

Kupiainen

et al. 2009

COPD: Journal of Chronic Obstructive Pulmonary Disease

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This study aims to compare diagnostic and clinical outcomes of Chronic Obstructive Pulmonary Disease (COPD) from the gender perspective using retrospective health care data and patient reported outcomes in a real-world setting. An electronic database was constructed from complete medical records of 844 COPD patients who were recruited in Helsinki and Turku University Central Hospitals during the years 2005-07. The patients were identified from the hospital discharge registries by ICD10 code J44.8 in the age group of 18-75 years of age. The medical history was obtained from all healthcare providers who had treated these patients during the previous 5-10 years; the study intends to continue their follow-up annually for the next 10 years. Thirty-six percent (N = 266) of the participants were women. The COPD diagnosis had been made at the same age for both genders. Women, however, reported significantly less pack-years than men. Compared to the men, the women displayed less advanced airway obstruction, but more severe gas transfer impairment. Parenchymal damage when evaluated by diffusion capacity correlated significantly stronger with FEV(1) (% of predicted) in women than men. The BMI index of the women was lower than that of the men. Cardiovascular diseases, diabetes and alcoholism were significantly more common in men, but women suffered more psychiatric conditions, especially depression. This cohort showed several significant gender dependent differences in the clinical presentation that need to taken under consideration in the assessment of COPD progression and the disease management.

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Pulmonary Diffusing Capacity and Volumes in Healthy Adults Measured with the Single Breath Technique

Cited by 7 publications

References 0 publications

New-onset adult asthma in relation to damp and moldy workplaces

New-onset adult asthma in relation to damp and moldy workplaces

Complete blood count, coagulation biomarkers, and lung function 6 months after critical COVID‐19

Real-World Clinical Data Identifies Gender-related Profiles in Chronic Obstructive Pulmonary Disease

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