Pulmonary diffusing capacity at basal and increased O2 uptake levels in anesthetized dogs

Piiper, Johannes; Huch, A.; Kötter, D.; Herbst, R.

doi:10.1016/0034-5687(69)90060-7

Cited by 29 publications

(3 citation statements)

References 41 publications

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“…The values of alveolar gas exchange parameters during spontaneous breathing are in general agreement with previously reported data [Aoyagi et al, 1965;Piiper et al, 1969], The mean D02 value calculated using PAio2, 1-05 mmole • min-1 • T o r r 1, is not different from that reported by Piiper et al [1969] in dogs of similar weight.…”

Section: Functional Inhomogeneitiessupporting

confidence: 81%

Comparison of Rebreathing and Steady-State Pulmonary Do<sub>2</sub> in Dogs Ventilated by Body Respirator

Adaro¹,

Teichmann²,

Lüdtke-Handjery³

et al. 1974

Respiration

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Alveolar gas exchange was studied com-paratively in anaesthetised dogs during spontaneous breathing and during artificial ventilation produced by a body respirator. The pulmonary O₂ diffusing capac- ity, D O₂, in particular, was measured, employing two different methods: the conventional steady-state method, using ideal alveolar P O₂ (D O₂SS) and a rebreathing method (Do_2RB). A considerable decrease (by a factor of 3) in both D o_2SS and D_O2RB was observed on transition from spontaneous breathing to artificial ventilation. Distributional inhomogeneities were found to be considerably increased during artificial ventilation as indicated by increased values of both alveolar dead space ventilation and venous admixture. The increased inhomogeneity was probably due to considerably decreased end-expiratory lung volume during artificial ventilation at mean intrapulmonary pressure zero. The observed reduction in D_O2 should, at least in part, be attributed to the enhanced distributional inhomogeneity during artificial ventilation at low lung volume. Apparently, D_O2SS and D_O2RB are affected about equally by distributional inequalities in the lung

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Section: Functional Inhomogeneitiessupporting

confidence: 81%

Comparison of Rebreathing and Steady-State Pulmonary Do<sub>2</sub> in Dogs Ventilated by Body Respirator

Adaro¹,

Teichmann²,

Lüdtke-Handjery³

et al. 1974

Respiration

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“…On the contrary, morphometric and physiological measurements of diffusing capacity are in better agreement for multicameral lungs (monitor and turtle) than for the teju, and are in poorest agreement for mammalian lungs (Table 5). e Siegwart et al (1971) f Haab et al (1964); resting g Piiper et al (1969); maximal YO, h Gehr et al (1981) Salorinne (1976); resting Turino et al (1969); exercise Although L1Pto, in Fig. The same may hold true for other species.…”

Section: Strategy In Sequence Of Anatomical Adaptations For Gas Exchamentioning

confidence: 92%

Reptilian Lungs

Perry¹

1983

Advances in Anatomy Embryology and Cell Biology

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“…Also Shepard et al [1958], artificially producing desaturation of mixed venous blood by causing hypoxia in normal subjects, consistently found D lco values higher than those associated with normal oxygenation. Unfortunately, the real meaning of this finding defies a clear-cut interpreta tion: special investigations designed to clarify whether the increase of D lco in hypoxia reflected a vascular response (increased Q) or owed merely to physical factors failed to produce a straightforward answer [Piiper et al, 1969;Hills, 1974],…”

Section: Discussionmentioning

confidence: 99%

Correlations between Lung-Transfer Factor, Ventilation, and Cardiac Output during Exercise

Rampulla¹,

Marconi²,

Beulcke³

et al. 1976

Respiration

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In nine healthy and young subject of either sex, undergoing three or four rounds of muscular exercise of increasing severity on a bicycle ergometer, the authors investigated the behavior of the lung transfer factor (DL_CO), pulmonary ventilation (V), alveolar ventilation (Va), and cardiac output (Q). In all instances they found a positive linear correlation between DL_CO and oxygen consumption (VO₂), at least up to 70 % of maximum oxygen consumption (VO_2max) (r = 0.935; p < 0.001). Dl_CO was found to increase linearly as a function of increasing V (r = 0.898; p < 0.001) and even more so of increasing Va (r = 0.919; p < 0.001). Also the relationship between Dl_CO and Q appeared linear in all subjects (r = 0.926; p < 0.001). On the other hand, individual DL_CO values showed considerable scatter at equal VO₂, V, V_A, and Q values. Among the factors responsible for the increase of DL_CO during muscular exercise, in addition to increased ventilation and cardiac output, the authors suggest the possible role of the greater desaturation of mixed venous blood and variations of hemoglobin affinity for CO.

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Pulmonary diffusing capacity at basal and increased O2 uptake levels in anesthetized dogs

Cited by 29 publications

References 41 publications

Comparison of Rebreathing and Steady-State Pulmonary Do<sub>2</sub> in Dogs Ventilated by Body Respirator

Comparison of Rebreathing and Steady-State Pulmonary Do<sub>2</sub> in Dogs Ventilated by Body Respirator

Reptilian Lungs

Correlations between Lung-Transfer Factor, Ventilation, and Cardiac Output during Exercise

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