Pulmonary Disease and Age at Immigration among Hispanics. Results from the Hispanic Community Health Study/Study of Latinos

Abstract

Rationale: Asthma has

A Genome-Wide Association Study in Hispanics/Latinos Identifies Novel Signals for Lung Function. The Hispanic Community Health Study/Study of Latinos

“…One identified a novel variant near MAN2B1 that was associated with percent emphysema on computed tomography (CT) (16) and the other identified two loci that approached genome wide statistical 4 significance for COPD (13). This literature contrasts with that among persons of European ancestry, in whom GWAS have identified multiple loci in genes for lung function and COPD (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31) To improve our current understanding of the genetic architecture of lung functionrelated traits in Hispanics/Latinos, we performed a meta-analysis for FEV1, FEV1/FVC, airflow limitation and COPD among six Hispanic/Latino groups in the HCHS/SOL cohort (10,32). Findings were replicated in European, Hispanic and African populations.…”

“…The study design, cohort recruitment (10,32), and baseline clinical examination (34) have been previously described. Institutional Review Boards at each field center approved study protocols and written informed consent was obtained from all participants.…”

“…Spirometry was conducted in accordance with American Thoracic Society/European Respiratory Society guidelines(36) using a dry rolling sealed spirometer as previously described (10). Participants with pre-bronchodilator FEV1/FVC ratios less than 70% or the lower limit of normal were selected for post-bronchodilator spirometry, the former defined by NHANES reference equations(37) since those from HCHS/SOL (38) were not available during data collection.…”

“…The prevalence of COPD in some Hispanic groups is lower than in non-Hispanic whites and African-Americans in the U.S. (8)(9)(10). In the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), the largest and best characterized cohort of Hispanics/Latinos in the US, the prevalence of COPD varied substantially by Hispanic/Latino heritage with Puerto Ricans and Cubans having a much higher prevalence of COPD than other Hispanic/Latino groups (10).…”

“…The prevalence of COPD in some Hispanic groups is lower than in non-Hispanic whites and African-Americans in the U.S. (8)(9)(10). In the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), the largest and best characterized cohort of Hispanics/Latinos in the US, the prevalence of COPD varied substantially by Hispanic/Latino heritage with Puerto Ricans and Cubans having a much higher prevalence of COPD than other Hispanic/Latino groups (10). This difference in HCHS/SOL was explained by smoking and asthma history; however, other investigators have noted that Hispanic ethnicity is inversely associated with COPD-phenotypes compared to whites (11,12) and have hypothesized that genetic differences may lower risk of COPD in some Hispanic groups (11,13).…”