Pulmonary diseases in childhood AIDS

Somu, N; Vijayasekaran, D; Ashok, Tejaswini; Balachandran, Aswini; Subramanyam, Lalitha

doi:10.1007/bf02751713

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…20 Outcome of TST in presence of close contact was not significant as seen by other study conducted in other parts of India. 21 Our study, had similar observations with high prevalence of Mantoux positivity among BCG vaccinated subjects that have been reported by workers in Africa as well. 22 The most common etiology of Mantoux test positive patients was EPTB (50.10%), PTB (29.30%), disseminated TB (12.90%) and latent TB in 07.70% patients.…”

Section: Interpretation Of Tuberculin Reactionsupporting

confidence: 92%

A study to evaluate the significance of Mantoux test investigated for tuberculosis in a tertiary care teaching hospital of India

Saborni Dey,

Siddarath Kumar,

Vivek Tyagi

et al. 2023

Asian J Med Sci

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Background: Tuberculosis (TB) is a serious illness that mainly affects the lungs. The Mantoux tuberculin skin test (TST) is one method of determining whether a person is infected with Mycobacterium tuberculosis. Reliable administration and reading of the TST requires standardization of procedures, training, supervision, and practice. Aims and Objectives: The objective was to determine the sensitivity and specificity of Mantoux test in pediatric patients for the diagnosis of TB. It also assists to study various presentations of TB in Mantoux test-positive patients. Materials and Methods: From August 2022 to January 2023, a single tertiary care facility named Saraswathi Institute of Medical Sciences, Hapur hosted this observational study after approval from the Institutional Ethical Committee. Participants in the trial included all children up to 15 years of age who has received Bacillus Calmette-Guérin at birth, were suspected of having TB and had been referred to a pediatric TB clinic. TST by 5 Tuberculin Unit Purified Protein Derivative-Standard was used to see induration of various sizes. The sensitivity, specificity, positive predictive value, negative predictive value and other metrics were calculated during the study by statistical software. Results: Out of 480 patients 36.87% (n=177) had TB with TST cut off≥15 mm indurations, while 169 patients had no induration. Most common age group affected was 5–10 years (48.59%) followed by 0–5 years (30.51%) and 10–15 years (20.90%) with male: female ratio = 1.2:1. Most common etiology for TST positive patients was pulmonary TB (PTB) (29.30%), extra PTB (50.10%), disseminated TB (12.90%) and latent TB (07.70%). The sensitivity of the test was 95.857% with 95% confidence interval (91.64–98.31%),specificity was 95.176% (92.16–97.29%). Its positive and negative predictive values were 91.525% and 97.689% respectively. Conclusion: TB can be diagnosed with the Mantoux test because of its high sensitivity and specificity but it should be explained carefully to avoid inaccurate interpretations.

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Section: Interpretation Of Tuberculin Reactionsupporting

confidence: 92%

A study to evaluate the significance of Mantoux test investigated for tuberculosis in a tertiary care teaching hospital of India

Saborni Dey,

Siddarath Kumar,

Vivek Tyagi

et al. 2023

Asian J Med Sci

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“…Éstos son la fuente más preciada de detección de casos. Así queda demostrado en todas las investigaciones que se han efectuado en el mundo sobre este tema por Somu N. y Vijayasckaron D. 16 , en la India en 1997. En ellas se evidenciaron que la mayoría de los niños ingresados en la sala de enfermedades respiratorias del hospital, habían sido contactos de adultos enfermos.…”

Section: Discussionunclassified

Quality control in the follow-up of pulmonary tuberculosis contacts in Camagüez, Cuba (2008-2011)

Dair¹,

Torres²,

Rodríguez³

et al. 2014

Medwave

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We found adequate compliance of National Program for the Control of the Tuberculosis guidelines for follow-up of contacts of positive cases of pulmonary tuberculosis. Compliance is greater in younger age groups and in the actively employed (25 to 54 years). This evaluation contributed to identify existing weaknesses in follow-up, such as low interest of this population to undergo appropriate testing in the National Program of Control of Tuberculosis.

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“…The studies including the larger retrospective series of children with miliary TB so far have all been published before the year 2000. [5][6][7][8][9] Since then, the TB diagnostic field has evolved significantly, with the introduction of interferon-gamma release assays, 10 Diaskin tests 11 and the wide-spread availability of molecular (PCRbased) TB tests, 12 even on specimens like stool 13 and urine. 14 These diagnostics are, however, expensive and require laboratory facilities that are, again, not routinely available in low-resource settings.…”

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confidence: 99%