Pulmonary disposition of antimicrobial agents: methodological considerations

Baldwin, David R; Honeybourne, D.; Wise, R.

doi:10.1128/aac.36.6.1171

Cited by 166 publications

(136 citation statements)

References 60 publications

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“…In cases of lower respiratory tract infections, chemical analysis of sputum (6,9,28) and analyses of tissue biopsy specimens and bronchoalveolar lavage fluid (15,32), epithelial lining fluid (4,35), and alveolar macrophages (12,13) have been performed to obtain information about the penetration of antibiotics into the lungs (3,16). However, the determination of concentrations of antibiotics in sputum is unreliable.…”

Section: Discussionmentioning

confidence: 99%

“…Concentrations of antibiotics have been measured in sputum samples (6,9,19,28), bronchoscopically harvested biopsy specimens, and bronchoalveolar lavage fluids (15,32). More sophisticated approaches include the determination of antibiotic concentrations in epithelial lining fluid (4,35) or in alveolar macrophages (12,13). Recently, imaging procedures such as planar gamma scintigraphy (21) and positron emission tomography (39) were applied to support the definition of optimal dosing schedules for respiratory tract infections.…”

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confidence: 99%

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Penetration of Meropenem into Pneumonic Human Lung Tissue as Measured by In Vivo Microdialysis

Tomaselli

Maier

Matzi

et al. 2004

Antimicrob Agents Chemother

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Until recently, information on antibiotic pharmacokinetic properties in infected human lung tissue was limited. We therefore studied a microdialysis-based approach for measurement of the penetration of meropenem into the extracellular space fluid of human pneumonic lung parenchyma. The lung penetration of meropenem was determined for seven patients with pneumonia and metapneumonic pleural empyema treated by decortication. Intraoperatively, two microdialysis probes were inserted into pneumonic lung tissue and one was inserted into healthy skeletal muscle for reference values.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Penetration of Meropenem into Pneumonic Human Lung Tissue as Measured by In Vivo Microdialysis

Tomaselli

Maier

Matzi

et al. 2004

Antimicrob Agents Chemother

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“…of bronchiolo-alveolar regions [2,15], but it may not be representative of concentration in bronchial regions but in more distal bronchiolar or alveolar regions. In addition, pulmonary disposition studies by BAL collected at a single time per subject does not provide any information on individual Cmax or AUC curve values in ELF.…”

Section: Bal Is An Established Technique For Measuring Antibiotic Conmentioning

confidence: 99%

“…Bronchial mucosal biopsy can also be used for measuring drug concentrations in bronchial -11 -regions; however, the most relevant information concerning the amount of drug in the interstitial fluid and cellular fluid is unknown [17]. While sputum is an easy fluid to obtain, its usefulness is complicated by possible contamination with saliva and blood [2]. Compared with these classical methods, BMS appears to be a reliable method for obtaining bronchial ELF safely, accurately, and repeatedly at multiple time points in one day with minimum contamination.…”

Section: Bal Is An Established Technique For Measuring Antibiotic Conmentioning

confidence: 99%

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Pharmacokinetics of telithromycin using bronchoscopic microsampling after single and multiple oral doses

Kikuchi

Yamazaki

Kikuchi

et al. 2007

Pulmonary Pharmacology & Therapeutics

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Objectives: Bronchoscopic microsampling (BMS) is a new technique for repeated sampling of bronchial epithelial lining fluid (ELF) to obtain the pharmacokinetic profile of drugs. We analyzed the time versus concentration profiles of telithromycin in bronchial ELF obtained by BMS and compared these finding to those in plasma and alveolar ELF obtained by bronchoalveolar lavage (BAL).Methods: Bronchial ELF samples were obtained from five healthy subjects using BMS probe at 0, 2, 3, 4, 6, 10 and 24 h after single or multiple oral doses of 600 mg of telithromycin. Alveolar ELF was also obtained by BAL 3 h after single or multiple oral doses of 600 mg of telithromycin. Results:The areas under the concentration-time curve from 0 to 24 h (AUC0-24) of telithromycin in plasma and bronchial ELF were 2.86 ± 0.60 and 19.5 ± 10.4 mg·h/l after single treatment and 3.60 ± 0.49 and 42.2 ± 22.7 mg·h/l after multiple treatments, respectively. Single and multiple oral doses of telithromycin produced significantly (p<0.05) higher AUC0-24 in bronchial ELF compared to those in plasma. While concentrations in bronchial ELF obtained by BMS were significantly lower than those in alveolar ELF obtained by BAL, they tended to be higher than those in plasma after multiple administration. The telithromycin concentrations obtained by BMS method were very consistent in bronchial ELF at different bronchi at one time point and at the same bronchus at different time points.Conclusions: Using the BMS technique, we could describe the pharmacokinetics of telithromycin in bronchial ELF. Furthermore, BMS was reasonably validated and reconfirmed to be a feasible and reliable method for measuring antimicrobial concentrations in bronchial ELF.-2 -

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Microdialysis in Lung Tissue: Monitoring of Exogenous and Endogenous Compounds

Feurstein

Zeitlinger

2011

Applications of Microdialysis in Pharmaceutical Science

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Pulmonary disposition of antimicrobial agents: methodological considerations

Cited by 166 publications

References 60 publications

Penetration of Meropenem into Pneumonic Human Lung Tissue as Measured by In Vivo Microdialysis

Penetration of Meropenem into Pneumonic Human Lung Tissue as Measured by In Vivo Microdialysis

Pharmacokinetics of telithromycin using bronchoscopic microsampling after single and multiple oral doses

Microdialysis in Lung Tissue: Monitoring of Exogenous and Endogenous Compounds

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