2011
DOI: 10.5731/pdajpst.2011.00704
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Pulmonary Drug Delivery: Novel Pharmaceutical Technologies Breathe New Life into the Lungs

Abstract: Pulmonary drug delivery is a developing technology in which medication is inhaled through the lungs and enters the bloodstream through the alveolar epithelium. Pulmonary drug delivery provides a noninvasive, alternative method to subcutaneous injection, and also intravenous injection. The delivery device plays a major role in the efficiency of pulmonary delivery, and great strides have been made in the development of new devices in recent years. The devices most commonly used for respiratory delivery, includin… Show more

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Cited by 24 publications
(21 citation statements)
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“…The rapid improvement in aerosol formulation and delivery devices could greatly change the landscape for therapy against lung cancer (Nanjwade et al , 2001; Gagnadoux et al , 2008). Clearly, the delivery of cytotoxins, drugs, and small molecules targeting genes or pathways to the primary tumour with minimal systemic toxicity will allow the testing of new combinatorial approaches and more intensive dose schedules.…”
Section: Discussionmentioning
confidence: 99%
“…The rapid improvement in aerosol formulation and delivery devices could greatly change the landscape for therapy against lung cancer (Nanjwade et al , 2001; Gagnadoux et al , 2008). Clearly, the delivery of cytotoxins, drugs, and small molecules targeting genes or pathways to the primary tumour with minimal systemic toxicity will allow the testing of new combinatorial approaches and more intensive dose schedules.…”
Section: Discussionmentioning
confidence: 99%
“…Traditional techniques such as grinding, spray drying and with the help of more recent advances in supercritical fluid extraction procedure, precipitation, and solvent extraction methods have also been employed to produce more efficient nanoparticle formulations for the treatment of pulmonary diseases. 128,129 …”
Section: Nanomedicine As An Emerging Therapeutic Approach For Real mentioning
confidence: 99%
“…DPIs are propellant free, portable, easy to use and cost-effective devices. Moreover, DPIs are activated by the inspiration effort of patients, allowing a rapid and higher dose administration and a more efficient pulmonary drug deposition [22,23]. Thus, DPIs are currently considered the most convenient and suitable alternative for inhaling anti-TB drugs [24].…”
Section: Particulate Carriers As Inhalable Delivery Systemsmentioning
confidence: 99%