Hanging, ligature strangulation, and manual methods can all result in fatal injuries such as fractures, dislocations, and brain swelling. This case involves a 30-year-old woman who survived a hanging incident but subsequently developed pulmonary and brain swelling. Post-obstructive pulmonary edema (POPE) is characterized by sudden onset non-neurogenic, non-cardiogenic fluid accumulation in the lungs following the removal of an acute upper respiratory tract obstruction. This report explores the patient's clinical presentation, disease progression, management strategies, and potential complications that clinicians may encounter during treatment, thereby enriching their understanding of possible outcomes and challenges in patient care.