Pulmonary edema due to ritodrine

Kayacan, Nurten Bostanoğlu; Döşemeci, L; Arıcı, G; Karsli, Birkan; Erman, Meliha

doi:10.5414/cpp42350

Cited by 2 publications

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“…The frequency of an amniotic fluid culture positive for microorganisms in patients presenting with an episode of Characteristics and outcomes of patients delivered within 7 days of amniocentesis and those who were undelivered for at least 7 days Original Research OBSTETRICS ajog.org preterm labor and intact membranes is approximately 10%, 3,6,12,14,33,139 and these patients are more likely to develop maternal complications such as clinical chorioamnionitis 3 and pulmonary edema while receiving tocolytics, 68,69 and to deliver a preterm neonate shortly after admission. 3,14,16,33,140,141 In addition, patients with intra-amniotic infection are more likely to show evidence of histologic chorioamnionitis (a maternal host response) or funisitis/ chorionic vasculitis (pathologic hallmarks of the fetal inflammatory response syndrome [FIRS]).…”

Section: Prevalence and Clinical Importance Of Intra-amniotic Infectimentioning

confidence: 99%

Antibiotic administration can eradicate intra-amniotic infection or intra-amniotic inflammation in a subset of patients with preterm labor and intact membranes

Yoon

Romero

Park

et al. 2019

American Journal of Obstetrics and Gynecology

119

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BACKGROUND: Intra-amniotic infection is present in 10% of patients with an episode of preterm labor, and is a risk factor for impending preterm delivery and neonatal morbidity/mortality. Intra-amniotic inflammation is often associated with intra-amniotic infection, but is sometimes present in the absence of detectable microorganisms. Antibiotic treatment of intraamniotic infection has traditionally been considered to be ineffective. Intra-amniotic inflammation without microorganisms has a prognosis similar to that of intra-amniotic infection. OBJECTIVE: To determine whether antibiotics can eradicate intraamniotic infection or intra-amniotic inflammation in a subset of patients with preterm labor and intact membranes. MATERIALS AND METHODS: The study population consisted of women who met the following criteria: 1) singleton gestation between 20 and 34 weeks; 2) preterm labor and intact membranes; 3) transabdominal amniocentesis performed for the evaluation of the microbiologic/inflammatory status of the amniotic cavity; 4) intra-amniotic infection and/or intra-amniotic inflammation; and 5) received antibiotic treatment that consisted of ceftriaxone, clarithromycin, and metronidazole. Follow-up amniocentesis was performed in a subset of patients. Amniotic fluid was cultured for aerobic and anaerobic bacteria and genital mycoplasmas, and polymerase chain reaction was performed for Ureaplasma spp. Intra-amniotic infection was defined as a positive amniotic fluid culture or positive polymerase chain reaction, and intra-amniotic inflammation was suspected when there was an elevated amniotic fluid white blood cell count or a positive result of a rapid test for matrix metalloproteinase-8. For this study, the final diagnosis of intra-amniotic inflammation was made by measuring the interleukin-6 concentration in stored amniotic fluid (>2.6 ng/mL). These results were not available to managing clinicians. Treatment success was defined as eradication of intra-amniotic infection and/or intra-amniotic inflammation or delivery !37 weeks. RESULTS: Of 62 patients with intra-amniotic infection and/or intraamniotic inflammation, 50 received the antibiotic regimen. Of those patients, 29 were undelivered for !7 days and 19 underwent a follow-up amniocentesis. Microorganisms were identified by culture or polymerase chain reaction of amniotic fluid obtained at admission in 21% of patients (4/19) who had a follow-up amniocentesis, and were eradicated in 3 of the 4 patients. Resolution of intra-amniotic infection/inflammation was confirmed in 79% of patients (15/19), and 1 other patient delivered at term, although resolution of intra-amniotic inflammation could not be confirmed after a follow-up amniocentesis. Thus, resolution of intraamniotic inflammation/infection or term delivery (treatment success) occurred in 84% of patients (16/19) who had a follow-up amniocentesis. Treatment success occurred in 32% of patients (16/50) with intraamniotic infection/inflammation who received antibiotics. The median amniocentesis-to-delivery interval w...

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Section: Prevalence and Clinical Importance Of Intra-amniotic Infectimentioning

confidence: 99%

Antibiotic administration can eradicate intra-amniotic infection or intra-amniotic inflammation in a subset of patients with preterm labor and intact membranes

Yoon

Romero

Park

et al. 2019

American Journal of Obstetrics and Gynecology

119

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Current awareness: Pharmacoepidemiology and drug safety

2004

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 19 sections: 1 Books, Reviews & Symposia; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Pulmonary edema due to ritodrine

Cited by 2 publications

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Antibiotic administration can eradicate intra-amniotic infection or intra-amniotic inflammation in a subset of patients with preterm labor and intact membranes

Antibiotic administration can eradicate intra-amniotic infection or intra-amniotic inflammation in a subset of patients with preterm labor and intact membranes

Current awareness: Pharmacoepidemiology and drug safety

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