1983
DOI: 10.1016/s0022-3476(83)80253-4
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Pulmonary effects of furosemide in preterm infants with lung disease

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Cited by 72 publications
(29 citation statements)
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“…2 Enteral furosemide produces minimal effect in preterm infants p3 weeks of age with chronic lung disease. 11 Chronic furosemide therapy improves pulmonary compliance, oxygen requirement and minute ventilation in preterm infants X3 Early or ongoing use of diuretics is associated with many significant adverse effects including ototoxicity, nephrolithiasis, PDA, cholelithiasis (loop diuretics), hypercalcemia, hyperkalemia, (thiazide/ potassium-sparing combination), electrolyte disarray, hypovolemia, hypotension, pre-renal failure, bone demineralization, nephrocalcinosis, hyperuricemia, cholestatic jaundice and hyperuricemia (either). 4,10,15 Despite this formidable list, risk of adverse effects appeared to be a lesser consideration in therapeutic decisions by survey respondents.…”
Section: Discussionmentioning
confidence: 99%
“…2 Enteral furosemide produces minimal effect in preterm infants p3 weeks of age with chronic lung disease. 11 Chronic furosemide therapy improves pulmonary compliance, oxygen requirement and minute ventilation in preterm infants X3 Early or ongoing use of diuretics is associated with many significant adverse effects including ototoxicity, nephrolithiasis, PDA, cholelithiasis (loop diuretics), hypercalcemia, hyperkalemia, (thiazide/ potassium-sparing combination), electrolyte disarray, hypovolemia, hypotension, pre-renal failure, bone demineralization, nephrocalcinosis, hyperuricemia, cholestatic jaundice and hyperuricemia (either). 4,10,15 Despite this formidable list, risk of adverse effects appeared to be a lesser consideration in therapeutic decisions by survey respondents.…”
Section: Discussionmentioning
confidence: 99%
“…Taken together, this provides evidence that furosemide has a direct, nonepithelial-dependent effect on airway smooth muscle tone. Systemically administered furosemide improves pulmonary mechanics and gas exchange in infants with chronic lung disease independent of its diuretic effects (1,2). Studies demonstrating a reduction of bronchoconstrictive responses in pediatric (3) and adult asthmatics (4, 5) with aerosolized furosemide further support the notion that a nondiuretic effect may produce improvements in pulmonary function.…”
mentioning
confidence: 94%
“…18 There is very little evidence to support routine use of diuretics in very-low birth-weight infants with respiratory distress syndrome or developing or established chronic lung disease. [6][7][8][9][10] The three trials that addressed mostly infants with postnatal ages of 7 to 28 days [19][20][21] looked at short-term renal and/or pulmonary outcomes varying from 24 to 96 h post treatment and not at long-term outcomes. Most trials of diuretics in preterm infants have only shown short-term effects on lung mechanics or oxygen requirement; these effects disappear as soon as the diuretics are stopped and do not shorten the duration of oxygen administration, long-term lung function or length of stay.…”
Section: -4mentioning
confidence: 99%