Pulmonary effects of the herbicide paraquat studied 3 days after injection in rats.

Fisher, H. Kenneth; Clements, J. A.; Wright, RR

doi:10.1152/jappl.1973.35.2.268

Cited by 40 publications

(8 citation statements)

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“…The results of this study are in line with several other reports [5][6][7]15]. We confirmed the suggestion by FISHER et al [5] that intra-alveolar oedema is present within 24 h after paraquat intoxication and that this model is a model not of primary surfactant synthesis damage, but of surfactant inhibition.…”

Section: Discussionsupporting

confidence: 93%

Surfactant therapy restores gas exchange in lung injury due to paraquat intoxication in rats

So¹,

Buijzer²,

Gommers³

et al. 1998

Eur Respir J

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Paraquat is a weed killer which causes often fatal lung damage in humans and other animals. There is evidence that the pulmonary surfactant system is involved in the pathophysiology of respiratory failure after paraquat intoxication and, therefore, the possible therapeutic effect of intratracheal surfactant administration on gas exchange in rats with progressive lung injury induced by paraquat poisoning was studied. In one group of rats, the time course of the development of lung injury due to paraquat intoxication was characterized. In a second group of rats, 72 h after paraquat intoxication, the animals underwent mechanical ventilation and only those animals in which the arterial oxygen tension/inspiratory oxygen fraction (Pa,O2/FI,O2) decreased to below 20 kPa (150 mmHg) received exogenous surfactant (200 mg x kg(-1) body weight). Within 3 days the rats in group 1 developed progressive respiratory failure, demonstrated not only by impaired gas exchange and lung mechanics but also by increased minimal surface tension and increased protein concentration in bronchoalveolar lavage fluid. In group 2, intratracheal surfactant administration increased Pa,O2/FI,O2 significantly within 5 min (14.4+/-2.4 kPa (108+/-18 mmHg)) to (55.2+/-53 kPa (414+/-40 mmHg)) and sustained this level for at least 2 h. It is concluded that intratracheal surfactant administration is a promising approach in the treatment of severe respiratory failure caused by paraquat poisoning.

show abstract

Section: Discussionsupporting

confidence: 93%

Surfactant therapy restores gas exchange in lung injury due to paraquat intoxication in rats

So¹,

Buijzer²,

Gommers³

et al. 1998

Eur Respir J

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show abstract

“…Ingestion of the herbicide, paraquat (Fisher et al, 1973), administration of fluorocarbons to animals (Alarie et al, 1972) and exposure to high concentrations of oxygen (Beckman & Weiss, 1969;Winter & Smith, 1972) are all thought to produce surfactant deficiencies. Furthermore, Finley & Ladman (1 972), found that surfactant levels obtained by endobronchial lavage were significantly less in cigarette smokers compared to non-smokers.…”

Section: Le Mesurier Et Atmentioning

confidence: 99%

Pulmonary responses to atmospheric pollutants. II. effect of petrol vapour inhalation on secretion of pulmonary surfactant

et al. 1979

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“…In the studies of Robertson -et al(103), as we.11 as Fisheret ale(33), paraquat 'administration did not produce any significant -…”

mentioning

confidence: 67%

Microsomal lipid peroxidation as a mechanism of cellular damage. [Dissertation]

Kornbrust¹

1979

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Pulmonary effects of the herbicide paraquat studied 3 days after injection in rats.

Cited by 40 publications

References 0 publications

Surfactant therapy restores gas exchange in lung injury due to paraquat intoxication in rats

Surfactant therapy restores gas exchange in lung injury due to paraquat intoxication in rats

Pulmonary responses to atmospheric pollutants. II. effect of petrol vapour inhalation on secretion of pulmonary surfactant

Microsomal lipid peroxidation as a mechanism of cellular damage. [Dissertation]

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