2024
DOI: 10.3390/ijms25053018
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Pulmonary Effects of Traumatic Brain Injury in Mice: A Gene Set Enrichment Analysis

Wei-Hung Chan,
Shih-Ming Huang,
Yi-Lin Chiu

Abstract: Acute lung injury occurs in 20–25% of cases following traumatic brain injury (TBI). We investigated changes in lung transcriptome expression post-TBI using animal models and bioinformatics. Employing unilateral controlled cortical impact for TBI, we conducted microarray analysis after lung acquisition, followed by gene set enrichment analysis of differentially expressed genes. Our findings indicate significant upregulation of inflammation-related genes and downregulation of nervous system genes. There was enha… Show more

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